Understanding the stress field at the lateral termination of a thrust fold using generic geomechanical models and clustering methods

Autor: A. Adwan, B. Maillot, P. Souloumiac, C. Barnes, C. Nussbaum, M. Rahn, T. Van Stiphout

Publikováno v: Solid Earth, Vol 15, Pp 1445-1463 (2024)

This study employs numerical simulations based on the limit analysis (LA) method to calculate the stress distribution in a model that includes a basal detachment, featuring the lateral termination of a generic fault under compression. We conduct 2500

Externí odkaz: https://doaj.org/article/0c53861b1d45437c8c90989cada81108

Whole-genome sequencing in 333,100 individuals reveals rare non-coding single variant and aggregate associations with height

Autor: Gareth Hawkes, Robin N. Beaumont, Zilin Li, Ravi Mandla, Xihao Li, Christine M. Albert, Donna K. Arnett, Allison E. Ashley-Koch, Aneel A. Ashrani, Kathleen C. Barnes, Eric Boerwinkle, Jennifer A. Brody, April P. Carson, Nathalie Chami, Yii-Der Ida Chen, Mina K. Chung, Joanne E. Curran, Dawood Darbar, Patrick T. Ellinor, Myrian Fornage, Victor R. Gordeuk, Xiuqing Guo, Jiang He, Chii-Min Hwu, Rita R. Kalyani, Robert Kaplan, Sharon L. R. Kardia, Charles Kooperberg, Ruth J. F. Loos, Steven A. Lubitz, Ryan L. Minster, Take Naseri, Satupa’itea Viali, Braxton D. Mitchell, Joanne M. Murabito, Nicholette D. Palmer, Bruce M. Psaty, Susan Redline, M. Benjamin Shoemaker, Edwin K. Silverman, Marilyn J. Telen, Scott T. Weiss, Lisa R. Yanek, Hufeng Zhou, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Ching-Ti Liu, Kari E. North, Anne E. Justice, Jonathan M. Locke, Nick Owens, Anna Murray, Kashyap Patel, Timothy M. Frayling, Caroline F. Wright, Andrew R. Wood, Xihong Lin, Alisa Manning, Michael N. Weedon

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)

Abstract The role of rare non-coding variation in complex human phenotypes is still largely unknown. To elucidate the impact of rare variants in regulatory elements, we performed a whole-genome sequencing association analysis for height using 333,100

Externí odkaz: https://doaj.org/article/b2e3a91ecb614324b7f2fdd7370d5155

Exploring cotton SFR2’s conundrum in response to cold stress

Autor: Samantha M. Surber, Ngoc Pham Thien Thao, Cailin N. Smith, Zachery D. Shomo, Allison C. Barnes, Rebecca L. Roston

Publikováno v: Plant Signaling & Behavior, Vol 19, Iss 1 (2024)

Cotton is an important agricultural crop to many regions across the globe but is sensitive to low-temperature exposure. The activity of the enzyme SENSITIVE TO FREEZING 2 (SFR2) improves cold tolerance of plants and produces trigalactosylsyldiacylgly

Externí odkaz: https://doaj.org/article/c633c205a2714165bb7c80ea16ec887a

Validation of human telomere length multi-ancestry meta-analysis association signals identifies POP5 and KBTBD6 as human telomere length regulation genes

Autor: Rebecca Keener, Surya B. Chhetri, Carla J. Connelly, Margaret A. Taub, Matthew P. Conomos, Joshua Weinstock, Bohan Ni, Benjamin Strober, Stella Aslibekyan, Paul L. Auer, Lucas Barwick, Lewis C. Becker, John Blangero, Eugene R. Bleecker, Jennifer A. Brody, Brian E. Cade, Juan C. Celedon, Yi-Cheng Chang, L. Adrienne Cupples, Brian Custer, Barry I. Freedman, Mark T. Gladwin, Susan R. Heckbert, Lifang Hou, Marguerite R. Irvin, Carmen R. Isasi, Jill M. Johnsen, Eimear E. Kenny, Charles Kooperberg, Ryan L. Minster, Take Naseri, Satupa’itea Viali, Sergei Nekhai, Nathan Pankratz, Patricia A. Peyser, Kent D. Taylor, Marilyn J. Telen, Baojun Wu, Lisa R. Yanek, Ivana V. Yang, Christine Albert, Donna K. Arnett, Allison E. Ashley-Koch, Kathleen C. Barnes, Joshua C. Bis, Thomas W. Blackwell, Eric Boerwinkle, Esteban G. Burchard, April P. Carson, Zhanghua Chen, Yii-Der Ida Chen, Dawood Darbar, Mariza de Andrade, Patrick T. Ellinor, Myriam Fornage, Bruce D. Gelb, Frank D. Gilliland, Jiang He, Talat Islam, Stefan Kaab, Sharon L. R. Kardia, Shannon Kelly, Barbara A. Konkle, Rajesh Kumar, Ruth J. F. Loos, Fernando D. Martinez, Stephen T. McGarvey, Deborah A. Meyers, Braxton D. Mitchell, Courtney G. Montgomery, Kari E. North, Nicholette D. Palmer, Juan M. Peralta, Benjamin A. Raby, Susan Redline, Stephen S. Rich, Dan Roden, Jerome I. Rotter, Ingo Ruczinski, David Schwartz, Frank Sciurba, M. Benjamin Shoemaker, Edwin K. Silverman, Moritz F. Sinner, Nicholas L. Smith, Albert V. Smith, Hemant K. Tiwari, Ramachandran S. Vasan, Scott T. Weiss, L. Keoki Williams, Yingze Zhang, Elad Ziv, Laura M. Raffield, Alexander P. Reiner, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, TOPMed Hematology and Hemostasis Working Group, TOPMed Structural Variation Working Group, Marios Arvanitis, Carol W. Greider, Rasika A. Mathias, Alexis Battle

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)

Abstract Genome-wide association studies (GWAS) have become well-powered to detect loci associated with telomere length. However, no prior work has validated genes nominated by GWAS to examine their role in telomere length regulation. We conducted a

Externí odkaz: https://doaj.org/article/3e293e6c932a4a42b553d789d690044b

Predictive genetic panel for adult asthma using machine learning methods

Autor: Luciano Gama da Silva Gomes, PhD, Álvaro Augusto Souza da Cruz, MD, PhD, Maria Borges Rabêlo de Santana, PhD, Gabriela Pimentel Pinheiro, PhD, Cinthia Vila Nova Santana, PhD, Carolina Barbosa Souza Santos, PhD, Meher Preethi Boorgula, MS, Monica Campbell, MS, Adelmir de Souza Machado, MD, PhD, Rafael Valente Veiga, PhD, Kathleen C. Barnes, PhD, Ryan dos Santos Costa, PhD, Camila Alexandrina Figueiredo, PhD

Publikováno v: Journal of Allergy and Clinical Immunology: Global, Vol 3, Iss 3, Pp 100282- (2024)

Background: Asthma is a chronic inflammatory disease of the airways that is heterogeneous and multifactorial, making its accurate characterization a complex process. Therefore, identifying the genetic variations associated with asthma and discovering

Externí odkaz: https://doaj.org/article/80f782c6ec9b42d0a7273d7d442aa0fe