Zobrazeno 1 - 10
of 600
pro vyhledávání: '"P. Brotchie"'
Autor:
Helen M. L. Frazer, Carlos A. Peña-Solorzano, Chun Fung Kwok, Michael S. Elliott, Yuanhong Chen, Chong Wang, The BRAIx Team, Jocelyn F. Lippey, John L. Hopper, Peter Brotchie, Gustavo Carneiro, Davis J. McCarthy
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract Artificial intelligence (AI) readers of mammograms compare favourably to individual radiologists in detecting breast cancer. However, AI readers cannot perform at the level of multi-reader systems used by screening programs in countries such
Externí odkaz:
https://doaj.org/article/2c201c5f842d4cf6b4d53d6962a08a8c
Inertial localisation is an important technique as it enables ego-motion estimation in conditions where external observers are unavailable. However, low-cost inertial sensors are inherently corrupted by bias and noise, which lead to unbound errors, m
Externí odkaz:
http://arxiv.org/abs/2303.01641
Autor:
Chinenyenwa Eze, Emma Brotchie
Publikováno v:
BJPsych Open, Vol 10, Pp S230-S231 (2024)
Aims •To find out the proportion of patients for whom the dates of births of their children, age and their due date were recorded during their initial assessment as a means of reducing risks through safeguarding. •According to the Royal College
Externí odkaz:
https://doaj.org/article/5e5a7bd2c901476496580fc1535d8d84
Autor:
Rhonda L. McFleder, Anastasiia Makhotkina, Janos Groh, Ursula Keber, Fabian Imdahl, Josefina Peña Mosca, Alina Peteranderl, Jingjing Wu, Sawako Tabuchi, Jan Hoffmann, Ann-Kathrin Karl, Axel Pagenstecher, Jörg Vogel, Andreas Beilhack, James B. Koprich, Jonathan M. Brotchie, Antoine-Emmanuel Saliba, Jens Volkmann, Chi Wang Ip
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Inflammation in the brain and gut is a critical component of several neurological diseases, such as Parkinson’s disease (PD). One trigger of the immune system in PD is aggregation of the pre-synaptic protein, α-synuclein (αSyn). Understa
Externí odkaz:
https://doaj.org/article/64b3f60bf6a74cc880822e0307d481d0
Autor:
Alexander Grotemeyer, Judith F. Fischer, James B. Koprich, Jonathan M. Brotchie, Robert Blum, Jens Volkmann, Chi Wang Ip
Publikováno v:
Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-14 (2023)
Abstract Neuroinflammation has been suggested as a pathogenetic mechanism contributing to Parkinson’s disease (PD). However, anti-inflammatory treatment strategies have not yet been established as a therapeutic option for PD patients. We have used
Externí odkaz:
https://doaj.org/article/940753474ea54cd0aeec7126dbf86613
Autor:
Mohammad Badr, Rhonda L. McFleder, Jingjing Wu, Susanne Knorr, James B. Koprich, Thomas Hünig, Jonathan M. Brotchie, Jens Volkmann, Manfred B. Lutz, Chi Wang Ip
Publikováno v:
Journal of Neuroinflammation, Vol 19, Iss 1, Pp 1-19 (2022)
Abstract Background Regulatory CD4+CD25+FoxP3+ T cells (Treg) are a subgroup of T lymphocytes involved in maintaining immune balance. Disturbance of Treg number and impaired suppressive function of Treg correlate with Parkinson’s disease severity.
Externí odkaz:
https://doaj.org/article/ded71ba65a6c4640bc37adca0c1102e3
Autor:
Melinda Wuest, Justin J. Bailey, Jennifer Dufour, Darryl Glubrecht, Vanessa Omana, Tom H. Johnston, Jonathan M. Brotchie, Ralf Schirrmacher
Publikováno v:
EJNMMI Research, Vol 12, Iss 1, Pp 1-16 (2022)
Abstract Background Tropomyosin receptor kinases (TrkA, TrkB, TrkC) are a family of tyrosine kinases primarily expressed in neuronal cells of the brain. Identification of oncogenic alterations in Trk expression as a driver in multiple tumor types has
Externí odkaz:
https://doaj.org/article/3dc92fdbba9e4cf8974624c528cb9b86
Akademický článek
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Akademický článek
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Autor:
Lina A. Matschke, Marlene A. Komadowski, Annette Stöhr, Bolam Lee, Martin T. Henrich, Markus Griesbach, Susanne Rinné, Fanni F. Geibl, Wei-Hua Chiu, James B. Koprich, Jonathan M. Brotchie, Aytug K. Kiper, Amalia M. Dolga, Wolfgang H. Oertel, Niels Decher
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Parkinson’s disease (PD) is clinically defined by the presence of the cardinal motor symptoms, which are associated with a loss of dopaminergic nigrostriatal neurons in the substantia nigra pars compacta (SNpc). While SNpc neurons serve as
Externí odkaz:
https://doaj.org/article/b4c64fe5027f4227873cb7742ebf70c7