Zobrazeno 1 - 10
of 1 657
pro vyhledávání: '"P. Bonhoeffer"'
Autor:
Bongratz, Fabian, Karmann, Markus, Holz, Adrian, Bonhoeffer, Moritz, Neumaier, Viktor, Deli, Sarah, Schmitz-Koep, Benita, Zimmer, Claus, Sorg, Christian, Thalhammer, Melissa, Hedderich, Dennis M, Wachinger, Christian
Meningeal lymphatic vessels (MLVs) are responsible for the drainage of waste products from the human brain. An impairment in their functionality has been associated with aging as well as brain disorders like multiple sclerosis and Alzheimer's disease
Externí odkaz:
http://arxiv.org/abs/2411.08537
Autor:
Joel Bauer, Uwe Lewin, Elizabeth Herbert, Julijana Gjorgjieva, Carl E. Schoonover, Andrew J. P. Fink, Tobias Rose, Tobias Bonhoeffer, Mark Hübener
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Representational drift—the gradual continuous change of neuronal representations—has been observed across many brain areas. It is unclear whether drift is caused by synaptic plasticity elicited by sensory experience, or by the intrinsic
Externí odkaz:
https://doaj.org/article/b3a527da8e5346fd8298a3296ee603ec
The many dimensions of combination therapy: How to combine antibiotics to limit resistance evolution
Publikováno v:
Evolutionary Applications, Vol 17, Iss 8, Pp n/a-n/a (2024)
Abstract In combination therapy, bacteria are challenged with two or more antibiotics simultaneously. Ideally, separate mutations are required to adapt to each of them, which is a priori expected to hinder the evolution of full resistance. Yet, the s
Externí odkaz:
https://doaj.org/article/f230c9086a0e466d87373a7f0f500e10
Autor:
Jérémie Scire, Jana S. Huisman, Ana Grosu, Daniel C. Angst, Adrian Lison, Jinzhou Li, Marloes H. Maathuis, Sebastian Bonhoeffer, Tanja Stadler
Publikováno v:
BMC Bioinformatics, Vol 24, Iss 1, Pp 1-26 (2023)
Abstract Background Accurate estimation of the effective reproductive number ( $$R_e$$ R e ) of epidemic outbreaks is of central relevance to public health policy and decision making. We present estimateR, an R package for the estimation of the repro
Externí odkaz:
https://doaj.org/article/97797c267d1848fea21cba797e28b44f
Publikováno v:
PLoS Computational Biology, Vol 20, Iss 2, p e1011774 (2024)
Dendritic spines are the seat of most excitatory synapses in the brain, and a cellular structure considered central to learning, memory, and activity-dependent plasticity. The quantification of dendritic spines from light microscopy data is usually p
Externí odkaz:
https://doaj.org/article/11c6891e9e78423cafcd463e2f9d3510
Autor:
Ashcroft, Peter, Huisman, Jana S., Lehtinen, Sonja, Bouman, Judith A., Althaus, Christian L., Regoes, Roland R., Bonhoeffer, Sebastian
The infectivity profile of an individual with COVID-19 is attributed to the paper Temporal dynamics in viral shedding and transmissibility of COVID-19 by He et al., published in Nature Medicine in April 2020. However, the analysis within this paper c
Externí odkaz:
http://arxiv.org/abs/2007.06602
The last decades have not only been characterized by an explosive growth of data, but also an increasing appreciation of data as a valuable resource. Their value comes with the ability to extract meaningful patterns that are of economic, societal or
Externí odkaz:
http://arxiv.org/abs/1912.04261
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Michael Schweitzer, Alfredo Mari, Tim Roloff, Esther Künzli, Stefanie Heller, Diana Albertos Torres, Marco Meola, Danica Nogarth, Leanid Laganenka, Lisa Prampolini, Helena M. B. Seth-Smith, Olivia Grüninger, Alexander Gensch, Josiane Reist, Sebastian Bonhoeffer, Wolf-Dietrich Hardt, Adrian Egli
Publikováno v:
Microbiology Research, Vol 14, Iss 1, Pp 177-189 (2023)
Introduction: Invading extended-spectrum beta-lactamase-producing Escherichia coli (ESBL-PE), non-ESBL E. coli, and other bacteria form a complex environment in the gut. The duration and dynamics of ESBL-PE colonization varies among individuals. Unde
Externí odkaz:
https://doaj.org/article/1e9b94db5f164dfd8fe7902699854719
Ecological effects of stress drive bacterial evolvability under sub-inhibitory antibiotic treatments
Publikováno v:
ISME Communications, Vol 2, Iss 1, Pp 1-7 (2022)
Abstract Stress is thought to increase mutation rate and thus to accelerate evolution. In the context of antibiotic resistance, sub-inhibitory treatments could then lead to enhanced evolvability, thereby fuelling the adaptation of pathogens. Combinin
Externí odkaz:
https://doaj.org/article/dc3f46776baf46988f1eca6406a777c8