Zobrazeno 1 - 10
of 727
pro vyhledávání: '"P. Blackshaw"'
Autor:
Mendoza, Marie Lisandra Zepeda, Agarwal, Sonali, Blackshaw, James A., Bol, Vanesa, Fazzi, Audrey, Fiorini, Filippo, Foreman, Amy Louise, George, Nancy, Johnson, Brett R., Martin, Brian, McComb, Dave, Mutasa-Gottgens, Euphemia, Parkinson, Helen, Romacker, Martin, Russell, Rolf, Ségard, Valérien, Tan, Shawn Zheng Kai, Teh, Wei Kheng, Winstanley, F. P., Wong, Benedict, Smith, Adrian M.
Knowledge management (KM) involves collecting, organizing, storing, and disseminating information to improve decision-making, innovation, and performance. Implementing KM at scale has become essential for organizations to effectively leverage vast ac
Externí odkaz:
http://arxiv.org/abs/2406.12313
This paper investigates the formation and propagation of wavefunction `branches' through the process of entanglement with the environment. While this process is a consequence of unitary dynamics, and hence significant to many if not all approaches to
Externí odkaz:
http://arxiv.org/abs/2402.06848
Autor:
Kurt Weir, Natasha Vega, Veronica F. Busa, Ben Sajdak, Les Kallestad, Dana Merriman, Krzysztof Palczewski, Joseph Carroll, Seth Blackshaw
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract Torpor encompasses diverse adaptations to extreme environmental stressors such as hibernation, aestivation, brumation, and daily torpor. Here we introduce StrokeofGenus, an analytic pipeline that identifies distinct transcriptomic states and
Externí odkaz:
https://doaj.org/article/0c7f1b6a2c8441f9b18eed9963bf5ab6
Autor:
Henri Leinonen, Jianye Zhang, Laurence M. Occelli, Umair Seemab, Elliot H. Choi, Luis Felipe L.P. Marinho, Janice Querubin, Alexander V. Kolesnikov, Anna Galinska, Katarzyna Kordecka, Thanh Hoang, Dominik Lewandowski, Timothy T. Lee, Elliott E. Einstein, David E. Einstein, Zhiqian Dong, Philip D. Kiser, Seth Blackshaw, Vladimir J. Kefalov, Marcin Tabaka, Andrzej Foik, Simon M. Petersen-Jones, Krzysztof Palczewski
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-22 (2024)
Abstract Inherited retinopathies are devastating diseases that in most cases lack treatment options. Disease-modifying therapies that mitigate pathophysiology regardless of the underlying genetic lesion are desirable due to the diversity of mutations
Externí odkaz:
https://doaj.org/article/b5b9cf370c114fd1b6b378a34d01cbf7
Autor:
Rogger P. Carmen-Orozco, William Tsao, Yingzhi Ye, Irika R. Sinha, Koping Chang, Vickie T. Trinh, William Chung, Kyra Bowden, Juan C. Troncoso, Seth Blackshaw, Lindsey R. Hayes, Shuying Sun, Philip C. Wong, Jonathan P. Ling
Publikováno v:
Molecular Neurodegeneration, Vol 19, Iss 1, Pp 1-17 (2024)
Abstract Background Cytoplasmic inclusions and loss of nuclear TDP-43 are key pathological features found in several neurodegenerative disorders, suggesting both gain- and loss-of-function mechanisms of disease. To study gain-of-function, TDP-43 over
Externí odkaz:
https://doaj.org/article/57aa4877bd6841eeb1d7825c31059ce8
Autor:
Cheng Qian, Ying Xin, Cheng Qi, Hui Wang, Bryan C. Dong, Donald J. Zack, Seth Blackshaw, Samer Hattar, Feng-Quan Zhou, Jiang Qian
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Previous studies of neuronal survival have primarily focused on identifying intrinsic mechanisms controlling the process. This study explored how intercellular communication contributes to retinal ganglion cell (RGC) survival following optic
Externí odkaz:
https://doaj.org/article/b1cda4bead69404db2565077129f3d56
Autor:
Anne G. M. Schilder, Stephan Wolpert, Shakeel Saeed, Leonie M. Middelink, Albert S. B. Edge, Helen Blackshaw, REGAIN Consortium, Kostas Pastiadis, Athanasios G. Bibas
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-9 (2024)
Abstract Inhibition of Notch signalling with a gamma-secretase inhibitor (GSI) induces mammalian hair cell regeneration and partial hearing restoration. In this proof-of-concept Phase I/IIa multiple-ascending dose open-label trial (ISRCTN59733689), a
Externí odkaz:
https://doaj.org/article/c507482871e1458b9e7192e6aabb92b2
Autor:
Pin Lyu, Maria Iribarne, Dmitri Serjanov, Yijie Zhai, Thanh Hoang, Leah J. Campbell, Patrick Boyd, Isabella Palazzo, Mikiko Nagashima, Nicholas J. Silva, Peter F. Hitchcock, Jiang Qian, David R. Hyde, Seth Blackshaw
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)
Abstract Following acute retinal damage, zebrafish possess the ability to regenerate all neuronal subtypes through Müller glia (MG) reprogramming and asymmetric cell division that produces a multipotent Müller glia-derived neuronal progenitor cell
Externí odkaz:
https://doaj.org/article/71690f1b09a744288c5a191665a5f721
Autor:
Qiang Liu, Benjamin J. Bell, Dong Won Kim, Sang Soo Lee, Mehmet F. Keles, Qili Liu, Ian D. Blum, Annette A. Wang, Elijah J. Blank, Jiali Xiong, Joseph L. Bedont, Anna J. Chang, Habon Issa, Jeremiah Y. Cohen, Seth Blackshaw, Mark N. Wu
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Circadian clocks generate rhythms of arousal, but the underlying molecular and cellular mechanisms remain unclear. In Drosophila, the clock output molecule WIDE AWAKE (WAKE) labels rhythmic neural networks and cyclically regulates sleep and
Externí odkaz:
https://doaj.org/article/8234d36b2f9147ce8f1a2a29b89103bf
Autor:
Breanne Darlene Tidemann, K. Neil Harker, Steve Shirtliffe, Christian Willenborg, Eric Johnson, Robert Gulden, Newton Z. Lupwayi, T. Kelly Turkington, Emma C. Stephens, Robert E. Blackshaw, Charles M. Geddes, Hiroshi Kubota, Greg Semach, Alick Mulenga, Cindy Gampe, Larry Michielsen, Patty Reid, Elizabeth Sroka, Jennifer Zuidhof
Publikováno v:
Frontiers in Agronomy, Vol 5 (2023)
Although herbicides have been a dominant and effective weed control strategy for decades in Western Canada, herbicide resistance and the lack of new modes of action have resulted in weed management challenges. Integrated weed management strategies ha
Externí odkaz:
https://doaj.org/article/531923e2dc55425cbe02a5b900e6346c