Zobrazeno 1 - 10
of 1 552
pro vyhledávání: '"P. Benzinger"'
Autor:
Kumar, Sayantan, Earnest, Tom, Yang, Braden, Kothapalli, Deydeep, Aschenbrenner, Andrew J., Hassenstab, Jason, Xiong, Chengie, Ances, Beau, Morris, John, Benzinger, Tammie L. S., Gordon, Brian A., Payne, Philip, Sotiras, Aristeidis
INTRODUCTION: Previous studies have applied normative modeling on a single neuroimaging modality to investigate Alzheimer Disease (AD) heterogeneity. We employed a deep learning-based multimodal normative framework to analyze individual-level variati
Externí odkaz:
http://arxiv.org/abs/2404.05748
Autor:
Junhao Wen, Zhijian Yang, Ilya M. Nasrallah, Yuhan Cui, Guray Erus, Dhivya Srinivasan, Ahmed Abdulkadir, Elizabeth Mamourian, Gyujoon Hwang, Ashish Singh, Mark Bergman, Jingxuan Bao, Erdem Varol, Zhen Zhou, Aleix Boquet-Pujadas, Jiong Chen, Arthur W. Toga, Andrew J. Saykin, Timothy J. Hohman, Paul M. Thompson, Sylvia Villeneuve, Randy Gollub, Aristeidis Sotiras, Katharina Wittfeld, Hans J. Grabe, Duygu Tosun, Murat Bilgel, Yang An, Daniel S. Marcus, Pamela LaMontagne, Tammie L. Benzinger, Susan R. Heckbert, Thomas R. Austin, Lenore J. Launer, Mark Espeland, Colin L. Masters, Paul Maruff, Jurgen Fripp, Sterling C. Johnson, John C. Morris, Marilyn S. Albert, R. Nick Bryan, Susan M. Resnick, Luigi Ferrucci, Yong Fan, Mohamad Habes, David Wolk, Li Shen, Haochang Shou, Christos Davatzikos
Publikováno v:
Translational Psychiatry, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Alzheimer’s disease (AD) is associated with heterogeneous atrophy patterns. We employed a semi-supervised representation learning technique known as Surreal-GAN, through which we identified two latent dimensional representations of brain a
Externí odkaz:
https://doaj.org/article/56d631e8319148739bce0f8e8b35d005
Autor:
Kwangsik Nho, Shannon L. Risacher, Liana G. Apostolova, Paula J. Bice, Jared R. Brosch, Rachael Deardorff, Kelley Faber, Martin R. Farlow, Tatiana Foroud, Sujuan Gao, Thea Rosewood, Jun Pyo Kim, Kelly Nudelman, Meichen Yu, Paul Aisen, Reisa Sperling, Basavaraj Hooli, Sergey Shcherbinin, Diana Svaldi, Clifford R. Jack, William J. Jagust, Susan Landau, Aparna Vasanthakumar, Jeffrey F. Waring, Vincent Doré, Simon M. Laws, Colin L. Masters, Tenielle Porter, Christopher C. Rowe, Victor L. Villemagne, Logan Dumitrescu, Timothy J. Hohman, Julia B. Libby, Elizabeth Mormino, Rachel F. Buckley, Keith Johnson, Hyun-Sik Yang, Ronald C. Petersen, Vijay K. Ramanan, Nilüfer Ertekin-Taner, Prashanthi Vemuri, Ann D. Cohen, Kang-Hsien Fan, M. Ilyas Kamboh, Oscar L. Lopez, David A. Bennett, Muhammad Ali, Tammie Benzinger, Carlos Cruchaga, Diana Hobbs, Philip L. De Jager, Masashi Fujita, Vaishnavi Jadhav, Bruce T. Lamb, Andy P. Tsai, Isabel Castanho, Jonathan Mill, Michael W. Weiner, for the Alzheimer’s Disease Neuroimaging Initiative (ADNI), the Department of Defense Alzheimer’s Disease Neuroimaging Initiative (DoD-ADNI), the Anti-Amyloid Treatment in Asymptomatic Alzheimer’s Study (A4 Study) and Longitudinal Evaluation of Amyloid Risk and Neurodegeneration (LEARN), the Australian Imaging, Biomarker & Lifestyle Study (AIBL), Andrew J. Saykin
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Determining the genetic architecture of Alzheimer’s disease pathologies can enhance mechanistic understanding and inform precision medicine strategies. Here, we perform a genome-wide association study of cortical tau quantified by positron
Externí odkaz:
https://doaj.org/article/534dba93d5bf4620975ce9a0f564baf7
Autor:
Catharina Roth, Leonie Maier, Bastian Abel, Patrick Roigk, Kilian Rapp, Oliver Schmidberger, Martin Bongartz, Simone Maier, Isabel Wirth, Brigitte Metz, Désirée Immel, Benjamin Finger, Sabine Schölch, Gisela Büchele, Oliver Deuster, Hans‑Helmut Koenig, Sophie Gottschalk, Judith Dams, William Micol, Jürgen M. Bauer, Michel Wensing, Petra Benzinger
Publikováno v:
BMC Geriatrics, Vol 24, Iss 1, Pp 1-18 (2024)
Abstract Background Geriatric rehabilitation aims at increasing physical and social activity and maintaining the functional reserve of older people. However, the continuity of geriatric rehabilitation in the outpatient setting is limited due to a lac
Externí odkaz:
https://doaj.org/article/c2d40c1ca297463d8c1adfad42418dc3
Publikováno v:
BMC Medical Ethics, Vol 25, Iss 1, Pp 1-10 (2024)
Abstract Background Artificial intelligence (AI) has revolutionized various healthcare domains, where AI algorithms sometimes even outperform human specialists. However, the field of clinical ethics has remained largely untouched by AI advances. This
Externí odkaz:
https://doaj.org/article/03fcdbbb5d88406889bbe1c40eca7e5b
Autor:
Maria Victoria Fernandez, Menghan Liu, Aleksandra Beric, Matt Johnson, Arda Cetin, Maulik Patel, John Budde, Pat Kohlfeld, Kristy Bergmann, Joseph Lowery, Allison Flynn, William Brock, Brenda Sanchez Montejo, Jen Gentsch, Nicholas Sykora, Joanne Norton, Olga Valdez, Priyanka Gorijala, Jessie Sanford, Yichen Sun, Ciyang Wang, Dan Western, Jigyasha Timsina, Tassia Mangetti Goncalves, Anh N. Do, Yun Ju Sung, Guoyan Zhao, John C. Morris, Krista Moulder, David M. Holtzman, Randall J. Bateman, Celeste Karch, Jason Hassenstab, Chengjie Xiong, Suzanne E. Schindler, Joyce (Joy) Balls-Berry, Tammie L. S. Benzinger, Richard J. Perrin, Andrea Denny, B. Joy Snider, Susan L. Stark, Laura Ibanez, Carlos Cruchaga
Publikováno v:
Scientific Data, Vol 11, Iss 1, Pp 1-19 (2024)
Abstract The Knight-Alzheimer Disease Research Center (Knight-ADRC) at Washington University in St. Louis has pioneered and led worldwide seminal studies that have expanded our clinical, social, pathological, and molecular understanding of Alzheimer
Externí odkaz:
https://doaj.org/article/1469c9617a64436fbff15b0d11b166cb
Autor:
Chengjie Xiong, Jingqin Luo, David A. Wolk, Leslie M. Shaw, Erik D. Roberson, Charles F. Murchison, Rachel L. Henson, Tammie L. S. Benzinger, Quoc Bui, Folasade Agboola, Elizabeth Grant, Emily N. Gremminger, Krista L. Moulder, David S. Geldmacher, Olivio J. Clay, Ganesh Babulal, Carlos Cruchaga, David M. Holtzman, Randall J. Bateman, John C. Morris, Suzanne E. Schindler
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-10 (2024)
Abstract Blood-based biomarkers of Alzheimer disease (AD) may facilitate testing of historically under-represented groups. The Study of Race to Understand Alzheimer Biomarkers (SORTOUT-AB) is a multi-center longitudinal study to compare AD biomarkers
Externí odkaz:
https://doaj.org/article/7e17f1f8091f4e35b67e41ede981da17
Autor:
Yang, Zhijian, Wen, Junhao, Abdulkadir, Ahmed, Cui, Yuhan, Erus, Guray, Mamourian, Elizabeth, Melhem, Randa, Srinivasan, Dhivya, Govindarajan, Sindhuja T., Chen, Jiong, Habes, Mohamad, Masters, Colin L., Maruff, Paul, Fripp, Jurgen, Ferrucci, Luigi, Albert, Marilyn S., Johnson, Sterling C., Morris, John C., LaMontagne, Pamela, Marcus, Daniel S., Benzinger, Tammie L. S., Wolk, David A., Shen, Li, Bao, Jingxuan, Resnick, Susan M., Shou, Haochang, Nasrallah, Ilya M., Davatzikos, Christos
Disease heterogeneity has been a critical challenge for precision diagnosis and treatment, especially in neurologic and neuropsychiatric diseases. Many diseases can display multiple distinct brain phenotypes across individuals, potentially reflecting
Externí odkaz:
http://arxiv.org/abs/2301.10772
Autor:
Jolie N Haun, Christopher A Fowler, Hari H Venkatachalam, Amy C Alman, Lisa M Ballistrea, Tali Schneider, Rachel C Benzinger, Christine Melillo, Neil B Alexander, S Angel Klanchar, William A Lapcevic, Matthew J Bair, Stephanie L Taylor, Jennifer L Murphy, Dustin D French
Publikováno v:
Journal of Medical Internet Research, Vol 26, p e57322 (2024)
BackgroundNonpharmacological interventions for veterans are needed to help them manage chronic pain and posttraumatic stress disorder (PTSD) symptoms. Complementary and integrative health (CIH) interventions such as Mission Reconnect (MR) seek to pro
Externí odkaz:
https://doaj.org/article/2862d72c250948c9806efb9720a0bd85
Autor:
Mary Jo Pugh, Jolie N Haun, P Jon White, Gerald Cochran, April F Mohanty, Lisa M McAndrew, Adam J Gordon, Richard E Nelson, Megan E Vanneman, Diana E Naranjo, Rachel C Benzinger, Audrey L Jones, Jacob Kean, Susan L Zickmund, Angela Fagerlin
Publikováno v:
JMIR Research Protocols, Vol 13, p e59830 (2024)
BackgroundAll federal agencies are required to support appropriation requests with evidence and evaluation (US Public Law 115-435; the Evidence Act). The StrAtegic PoLicy EvIdence-Based Evaluation CeNTer (SALIENT) is 1 of 6 centers that help the Depa
Externí odkaz:
https://doaj.org/article/fee90a16a0554c1681b96045e4864644