Inhaled Volatiles for Status Asthmaticus, Epilepsy, and Difficult Sedation in Adult ICU and PICU: A Systematic Review

Autor: Kevin Gorsky, MD, Sean Cuninghame, MD, Kesikan Jayaraj, RN, Marat Slessarev, MD, PhD, FRCPC, Conall Francoeur, MD, Davinia E. Withington, BM, FRCA, MRCP(UK), Jennifer Chen, Brian H. Cuthbertson, MBBS, PhD, Claudio Martin, MD, Martin Chapman, MD, FRCPC, Saptharishi Lalgudi Ganesan, MBBS, MD, DM, FACNS, Nicole McKinnon, MD, PhD, Angela Jerath, MD, MSc, FANZCA, FRCPC, on behalf of the SAVE-ICU Study Investigators, Martin Chapman, Damon Scales, Julie Nardi, Beth Linseman, Phil Lau, Boris Yakubov, Eily Shaw, Francois Carrier, Emmanuel Charbonney, Michaël Chassé, Martin Girard, Antoine Halwagi, Guillaume Plourde, Han Ting Wang, Frédérick D’Aragon, Maxime Tissot-Therrien, François Lamontagne, Dominique Bérard, Yiorgos Alexandros Cavayas, Martin Albert, Francis Bernard, Karim Serri, David Williamson, Virginie Williams, Patricia Martinez Barrios, Sabrina Araujo De Franca, Etienne J. Couture, Adreanne Côté, Mathieu Simon, Pierre-Alexis Lépine, Dave Gleeton, John Basmaji, Marat Slessarev, Ahmed Hegazy, Tracey Bentall, Eileen Campbell, Michelle Stephens, Tim Winterburn, Roupen Hatzakorzian, Kosar Khwaja, Peter Goldberg, Jason Shahin, Jeremy Richard Grushka, Jonathan Hooper, Sherissa Microys, Hilary Meggison, David Leilipovitz, Jessica Haines, Irene Watpool, Rebecca Porteous, Stephanie Dunster, Sylvie Bourbonnais, Ewan Goligher, Lorenzo Del Sorbo, Niall Ferguson, Philip Graham, Michael Long, Tina Yan, Denise Morris, Maria Kobylecky, Hesham Abdelhady, Tina Romagnuolo, Bourke Tillman, Ian Randall, Elizabeth Wilcox, Michael Jacka, Oleksa Rewa, Vincent Lau, Sean Bagshaw, Nadia Baig

Publikováno v: Critical Care Explorations, Vol 6, Iss 2, p e1050 (2024)

OBJECTIVES:. Inhaled volatile anesthetics support management of status asthmaticus (SA), status epilepticus (SE), and difficult sedation (DS). This study aimed to evaluate the effectiveness, safety, and feasibility of using inhaled anesthetics for SA

Externí odkaz: https://doaj.org/article/09dd4ac197df40d8a3e5362193889a15

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Study protocol for a randomized controlled trial of Proportional Assist Ventilation for Minimizing the Duration of Mechanical Ventilation: the PROMIZING study

Autor: Karen J. Bosma, Claudio M. Martin, Karen E. A. Burns, Jordi Mancebo Cortes, Juan Carlos Suárez Montero, Yoanna Skrobik, Kevin E. Thorpe, Andre Carlos Kajdacsy-Balla Amaral, Yaseen Arabi, John Basmaji, Gaëtan Beduneau, Francois Beloncle, Guillaume Carteaux, Emmanuel Charbonney, Alexandre Demoule, Martin Dres, Vito Fanelli, Anna Geagea, Ewan Goligher, François Lellouche, Tommaso Maraffi, Alain Mercat, Pablo O. Rodriguez, Jason Shahin, Stephanie Sibley, Savino Spadaro, Katerina Vaporidi, M. Elizabeth Wilcox, Laurent Brochard, On behalf of the Canadian Critical Care Trials Group and, the REVA Network

Publikováno v: Trials, Vol 24, Iss 1, Pp 1-18 (2023)

Abstract Background Proportional assist ventilation with load-adjustable gain factors (PAV+) is a mechanical ventilation mode that delivers assistance to breathe in proportion to the patient’s effort. The proportional assistance, called the gain, c

Externí odkaz: https://doaj.org/article/1291366322d74ccf8cffbc06bb284085

Annexin A5 in Patients With Severe COVID-19 Disease: A Single-Center, Randomized, Double-Blind, Placebo-Controlled Feasibility Trial

Autor: Claudio M. Martin, MD, Marat Slessarev, MD, PhD, Eileen Campbell, John Basmaji, MD, Ian Ball, MD, Douglas D. Fraser, MD, PhD, Aleksandra Leligdowicz, MD, PhD, Tina Mele, MD, PhD, Fran Priestap, MSc, Brent J. Tschirhart, MSc, Tracey Bentall, RN, Xiangru Lu, MD, Qingping Feng, MD, PhD

Publikováno v: Critical Care Explorations, Vol 5, Iss 10, p e0986 (2023)

OBJECTIVES:. To evaluate the study design and feasibility of drug administration and safety in a randomized clinical trial of recombinant human annexin A5 (SY-005), a constitutively expressed protein with anti-inflammatory, antiapoptotic, and anticoa

Externí odkaz: https://doaj.org/article/f02c7cacc2d4428e8e38bedbb729b0c7

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