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Inhibitory Effect of a Hydrophilic α-Tocopherol Analogue, MDL 74, 405, on Generation of Free Radicals in Stunned Myocardium in Dogs

Autor: Craig J. Hartley, Xian Liang Tang, P. B. Mccay, Roberto Bolli, Margo Schleman, Jian Zhong Sun

Publikováno v: Free Radical Research. 22:293-302

A previous study has demonstrated that the hydrophilic (alpha-tocopherol analogue, MDL 74,405, attenuates postischemic myocardial dysfunction ("stunning") in dogs. The present study was undertaken to determine directly whether the salutary effect of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b42d53501623be8cf1025ec920ba97a
https://doi.org/10.3109/10715769509145641

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Free radical formation in livers of rats treated acutely and chronically with alcohol

Autor: L A, Reinke, D R, Moore, P B, McCay

Publikováno v: Alcoholism, clinical and experimental research. 21(4)

The spin trapping method was used to assess formation of free radical intermediates in vivo before and after acute alcohol administration to rats. Ascorbyl radicals and spin adducts of dietary alcohol or endogenous compounds, such as lipids, were det

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c70fcfd6f8ff81236520638d820e8ef1
https://pubmed.ncbi.nlm.nih.gov/9194918

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Recurrent ischemia in the canine heart causes recurrent bursts of free radical production that have a cumulative effect on contractile function. A pathophysiological basis for chronic myocardial 'stunning'

Autor: J Z Sun, Xian Liang Tang, Roberto Bolli, J F Triana, X. Y. Li, P B McCay, M Zughaib

Publikováno v: The Journal of clinical investigation. 96(2)

Open-chest dogs (total number used, 117) underwent 10 5-min coronary occlusions (O) interspersed with 10 min of reperfusion (R). When systolic thickening fraction was measured 9 min after each R, the first O-R cycle was found to cause the largest dec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13ed08b3bf4a0cbaea209efb51d438d0
https://pubmed.ncbi.nlm.nih.gov/7635943

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A new model for inducing total hepatic ischemia while preventing circulatory collapse secondary to splanchnic vascular congestion

Autor: M E, Gonce, D J, Brackett, R A, Squires, D D, Gibson, A, Kajdacsy-Balla, M R, Lerner, P B, McCay, L R, Pennington

Publikováno v: Shock (Augusta, Ga.). 3(6)

Animal models used to study liver ischemia are limited by the lethal effect of splanchnic venous engorgement from portal triad occlusion (PTO). We compared a passive porto-systemic shunt (PSS) to a pump-driven PSS. The passive and pumped PSS groups (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::482550b86fa6f0ca22de174ec30a6763
https://pubmed.ncbi.nlm.nih.gov/7656069

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Metabolism of ethanol to 1-hydroxyethyl radicals in vivo: detection with intravenous administration of alpha-(4-pyridyl-1-oxide)-N-t-butylnitrone

Autor: D R, Moore, L A, Reinke, P B, McCay

Publikováno v: Molecular pharmacology. 47(6)

Intravenous administration of the spin-trapping agent alpha-(4-pyridyl-1-oxide)-N-t-butylnitrone (POBN) to anesthetized but otherwise untreated rats was used to test for formation of 1-hydroxyethyl radicals in vivo. The only EPR signals observed in b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e91cfe110c7633ca2c1f061017b6994a
https://pubmed.ncbi.nlm.nih.gov/7603464

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Direct evidence that the hydroxyl radical plays a pathogenetic role in myocardial 'stunning' in the conscious dog and demonstration that stunning can be markedly attenuated without subsequent adverse effects

Autor: Jian-Zhong Sun, Liang Tang, Selim Sekili, Roberto Bolli, J. I. Thornby, P. B. Mccay, Xiao-Ying Li, Marcel E. Zughaib

Publikováno v: Circulation research. 73(4)

Recent studies suggest that the hydroxyl radical (.OH) plays a pathogenetic role in postischemic ventricular dysfunction (myocardial "stunning"). This concept, however, is predicated exclusively on results obtained in anesthetized open-chest preparat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0aecaef910f212e081713bf4631a6486
https://pubmed.ncbi.nlm.nih.gov/8396504

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