Zobrazeno 1 - 10
of 11
pro vyhledávání: '"P. B. Maples"'
Autor:
Fred J. Clubb, N Montalvo, H Maass, Z. Wang, Matthew W. Miller, F C Brunicardi, Chris M. Jay, D D Rao, C Ruoff, Brad R. Weeks, Neil Senzer, Leonard A. King, Theresa W. Fossum, P B Maples, S-H Liu, Guisheng Zhou, V Gresham, B Spanhel, A Arrington, C Evans, P Kumar, John Nemunaitis
Publikováno v:
Cancer Gene Therapy. 20:683-689
PDX1 (pancreatic and duodenal homeobox 1) is overexpressed in pancreatic cancer, and its reduction results in tumor regression. Bi-functional pbi-shRNA PDX1 nanoparticle (OFHIRNA-PDX1) utilizes the endogenous micro-RNA biogenesis pathway to effect cl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::542ba32651bf8b1b2d4a0362ba2df57a
https://doi.org/10.1038/cgt.2013.68
https://doi.org/10.1038/cgt.2013.68
Autor:
D. Shanahan, D D Rao, A P Phadke, P B Maples, Craig P. Webb, Neil Senzer, Stephanie B. Scott, Y Yu, J Kuhn, Chris M. Jay, B O Pappen, S Chen, Dawna Dylewski, C Haddock, Z Wang, P Kumar, John Nemunaitis, David J. Monsma, Alex W. Tong
Publikováno v:
Cancer Gene Therapy. 17:780-791
RNA interference (RNAi) is a natural cellular regulatory process that inhibits gene expression by transcriptional, post-transcriptional and translational mechanisms. Synthetic approaches that emulate this process (small interfering RNA (siRNA), short
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e008db8391e2578b57976e97d1fbf6e6
https://doi.org/10.1038/cgt.2010.35
https://doi.org/10.1038/cgt.2010.35
Autor:
Guisheng Zhou, P B Maples, Juehua Yu, N Templeton, D D Rao, Robbi Sanchez, Shi-He Liu, F C Brunicardi, Neil Senzer, Chris M. Jay, P Kumar, John Nemunaitis, James X. Wu
Publikováno v:
Cancer gene therapy. 21(2)
RNA interference (RNAi) represents a powerful, new tool for scientific investigation as well as a promising new form of targeted gene therapy, with applications currently in clinical trials. Bifunctional short hairpin RNA (shRNA) are synthetic RNAi m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::937b21918b6a34ba157463631d7cd867
https://pubmed.ncbi.nlm.nih.gov/24457987
https://pubmed.ncbi.nlm.nih.gov/24457987
Autor:
D Shawler, Neil Senzer, P Snitz, P B Maples, Michael Nemunaitis, B O Pappen, P Kumar, John Nemunaitis, C. Bedell, H Fakhrai
Publikováno v:
Cancer gene therapy. 16(8)
In a previous dose escalation trial we demonstrated dose related survival correlation to Belagenpumatucel-L. In order to further evaluate safety and response at the previously defined optimal dose and schedule and to gain preliminary evidence on a hy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d41745acc3822d9427241ec764cf006
https://pubmed.ncbi.nlm.nih.gov/19287371
https://pubmed.ncbi.nlm.nih.gov/19287371
Publikováno v:
Molecular and Cellular Biology. 10:3591-3595
The IW32, NN10, and IW201 cell lines are erythroleukemic cell lines isolated from the spleens of mice infected with the Friend virus. IW32 and NN10 cells can be induced toward erythroid differentiation and hemoglobin synthesis by hemin or butyrate. B
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2e4e9fcbad9ebfb87d640f7780f1ad3d
https://doi.org/10.1128/mcb.10.7.3591
https://doi.org/10.1128/mcb.10.7.3591
Autor:
John Nemunaitis, Neil Senzer, Arzaga R, Sarmiento S, Zhang Ya, Alex W. Tong, P B Maples, Bruce E. Sands
Publikováno v:
Cancer gene therapy. 14(11)
ONYX-015 is an attenuated chimeric human group C adenovirus, which preferentially replicates in and lyses tumor cells that are p53 negative. The purpose of this phase I, dose-escalation study was to determine the safety and feasibility of intravenous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41dfb26bd224e858935fc98503909959
https://pubmed.ncbi.nlm.nih.gov/17704755
https://pubmed.ncbi.nlm.nih.gov/17704755
Autor:
J Kuhn, Y. Shen, Zhou Y, Jeffrey P. Lamont, Iya Khalil, Zhang Ya, D D Rao, Colin Hill, P B Maples, D. Shanahan, P Kumar, John Nemunaitis, John S. Vorhies, Neil Senzer, Michael Nemunaitis, Alex W. Tong
Publikováno v:
Cancer gene therapy. 14(8)
To identify signature targets associated with patient-specific cancer lesions based on tumor versus normal tissue differential protein and mRNA coexpression patterns for the purpose of synthesizing cancer-specific customized RNA interference knockdow
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44817f915202f39a81652b614bcc7371
https://pubmed.ncbi.nlm.nih.gov/17541424
https://pubmed.ncbi.nlm.nih.gov/17541424
Publikováno v:
Clinical lung cancer. 2(3)
Non–small-cell lung cancer frequently contains oncogenetic defects (mutations in ras , retinoblastoma, and p53 genes) that contribute to disease pathophysiology. Recent studies and clinical trials have focused on gene therapy approaches that either
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f14dbb0d486a905b2cbb6fbb236473c
https://pubmed.ncbi.nlm.nih.gov/14700482
https://pubmed.ncbi.nlm.nih.gov/14700482
Autor:
B. Seamour, S. Vukelja, Donald A. Richards, John Nemunaitis, P. B. Maples, Alex W. Tong, L. Stein, J. M. Lawson, William J. Hyman, G. Ordonez
Publikováno v:
American journal of clinical oncology. 23(5)
The purpose of this study is to determine immune recovery and function after treatment with docetaxel or paclitaxel. Peripheral blood mononuclear cells were harvested before chemotherapy and at weekly times afterwards for cycle 1. Leukocyte subsets I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::061171cc0337118322b9a19ff241b02d
https://pubmed.ncbi.nlm.nih.gov/11039505
https://pubmed.ncbi.nlm.nih.gov/11039505
Autor:
S L, Smith, J G, Bender, P B, Maples, K, Unverzagt, M, Schilling, L, Lum, S, Williams, D E, Van Epps
Publikováno v:
Experimental hematology. 21(7)
The growth and differentiation of selected bone marrow CD34+ cells stimulated with hematopoietic growth factors in lipid cultures were evaluated to determine whether cell types that may be useful for reducing the neutropenia associated with high-dose
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::00003238308f5813460f7a4769a0209e
https://pubmed.ncbi.nlm.nih.gov/7686502
https://pubmed.ncbi.nlm.nih.gov/7686502