Analysis of Plasmodium vivax schizont transcriptomes from field isolates reveals heterogeneity of expression of genes involved in host-parasite interactions

Autor: Sasha V. Siegel, Lia Chappell, Jessica B. Hostetler, Chanaki Amaratunga, Seila Suon, Ulrike Böhme, Matthew Berriman, Rick M. Fairhurst, Julian C. Rayner

Publikováno v: Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)

Abstract Plasmodium vivax gene regulation remains difficult to study due to the lack of a robust in vitro culture method, low parasite densities in peripheral circulation and asynchronous parasite development. We adapted an RNA-seq protocol “DAFT-s

Externí odkaz: https://doaj.org/article/c2c28e9b7b754adc9f200b9d0768dd5b

Asymptomatic Plasmodium vivax infections induce robust IgG responses to multiple blood-stage proteins in a low-transmission region of western Thailand

Autor: Rhea J. Longley, Camila T. França, Michael T. White, Chalermpon Kumpitak, Patiwat Sa-angchai, Jakub Gruszczyk, Jessica B. Hostetler, Anjali Yadava, Christopher L. King, Rick M. Fairhurst, Julian C. Rayner, Wai-Hong Tham, Wang Nguitragool, Jetsumon Sattabongkot, Ivo Mueller

Publikováno v: Malaria Journal, Vol 16, Iss 1, Pp 1-13 (2017)

Abstract Background Thailand is aiming to eliminate malaria by the year 2024. Plasmodium vivax has now become the dominant species causing malaria within the country, and a high proportion of infections are asymptomatic. A better understanding of ant

Externí odkaz: https://doaj.org/article/e28a89982df6427788c18723811ff82f

Genomic insights into the Ixodes scapularis tick vector of Lyme disease

Autor: Monika Gulia-Nuss, Andrew B. Nuss, Jason M. Meyer, Daniel E. Sonenshine, R. Michael Roe, Robert M. Waterhouse, David B. Sattelle, José de la Fuente, Jose M. Ribeiro, Karine Megy, Jyothi Thimmapuram, Jason R. Miller, Brian P. Walenz, Sergey Koren, Jessica B. Hostetler, Mathangi Thiagarajan, Vinita S. Joardar, Linda I. Hannick, Shelby Bidwell, Martin P. Hammond, Sarah Young, Qiandong Zeng, Jenica L. Abrudan, Francisca C. Almeida, Nieves Ayllón, Ketaki Bhide, Brooke W. Bissinger, Elena Bonzon-Kulichenko, Steven D. Buckingham, Daniel R. Caffrey, Melissa J. Caimano, Vincent Croset, Timothy Driscoll, Don Gilbert, Joseph J. Gillespie, Gloria I. Giraldo-Calderón, Jeffrey M. Grabowski, David Jiang, Sayed M. S. Khalil, Donghun Kim, Katherine M. Kocan, Juraj Koči, Richard J. Kuhn, Timothy J. Kurtti, Kristin Lees, Emma G. Lang, Ryan C. Kennedy, Hyeogsun Kwon, Rushika Perera, Yumin Qi, Justin D. Radolf, Joyce M. Sakamoto, Alejandro Sánchez-Gracia, Maiara S. Severo, Neal Silverman, Ladislav Šimo, Marta Tojo, Cristian Tornador, Janice P. Van Zee, Jesús Vázquez, Filipe G. Vieira, Margarita Villar, Adam R. Wespiser, Yunlong Yang, Jiwei Zhu, Peter Arensburger, Patricia V. Pietrantonio, Stephen C. Barker, Renfu Shao, Evgeny M. Zdobnov, Frank Hauser, Cornelis J. P. Grimmelikhuijzen, Yoonseong Park, Julio Rozas, Richard Benton, Joao H. F. Pedra, David R. Nelson, Maria F. Unger, Jose M. C. Tubio, Zhijian Tu, Hugh M. Robertson, Martin Shumway, Granger Sutton, Jennifer R. Wortman, Daniel Lawson, Stephen K. Wikel, Vishvanath M. Nene, Claire M. Fraser, Frank H. Collins, Bruce Birren, Karen E. Nelson, Elisabet Caler, Catherine A. Hill

Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)

Ticks transmit a large number of pathogens that cause human diseases. Here, the authors sequence the genome of the tick Ixodes scapularisand uncover expansion of genes associated with parasitic processes unique to ticks and tick-host interactions.

Externí odkaz: https://doaj.org/article/fa4043b3779c4d0db50b094e385f7e3b

Independent Origin and Global Distribution of Distinct Plasmodium vivax Duffy Binding Protein Gene Duplications.

Autor: Jessica B Hostetler, Eugenia Lo, Usheer Kanjee, Chanaki Amaratunga, Seila Suon, Sokunthea Sreng, Sivanna Mao, Delenasaw Yewhalaw, Anjali Mascarenhas, Dominic P Kwiatkowski, Marcelo U Ferreira, Pradipsinh K Rathod, Guiyun Yan, Rick M Fairhurst, Manoj T Duraisingh, Julian C Rayner

Publikováno v: PLoS Neglected Tropical Diseases, Vol 10, Iss 10, p e0005091 (2016)

BACKGROUND:Plasmodium vivax causes the majority of malaria episodes outside Africa, but remains a relatively understudied pathogen. The pathology of P. vivax infection depends critically on the parasite's ability to recognize and invade human erythro

Externí odkaz: https://doaj.org/article/5cca817890834c7d8734e9896a7f3401

A Library of Plasmodium vivax Recombinant Merozoite Proteins Reveals New Vaccine Candidates and Protein-Protein Interactions.

Autor: Jessica B Hostetler, Sumana Sharma, S Josefin Bartholdson, Gavin J Wright, Rick M Fairhurst, Julian C Rayner

Publikováno v: PLoS Neglected Tropical Diseases, Vol 9, Iss 12, p e0004264 (2015)

BACKGROUND:A vaccine targeting Plasmodium vivax will be an essential component of any comprehensive malaria elimination program, but major gaps in our understanding of P. vivax biology, including the protein-protein interactions that mediate merozoit

Externí odkaz: https://doaj.org/article/0fbe5be016614fdeaf7f0fe3e15c42e8