Zobrazeno 1 - 10
of 23
pro vyhledávání: '"P. B. Dirks"'
Publikováno v:
STAR Protocols, Vol 5, Iss 3, Pp 103260- (2024)
Summary: Cancer stem cells (CSCs) established from surgical biopsies closely mimic the human context and can be used to investigate disease mechanisms, genetic fitness, and therapeutic evaluation. Here, we present a protocol for the derivation of pri
Externí odkaz:
https://doaj.org/article/1bc5101bac0443238e48891b18b50ee4
Publikováno v:
Journal of Applied Poultry Research, Vol 33, Iss 1, Pp 100387- (2024)
SUMMARY: Poultry feed could represent 70% of the total production costs and with the constant increase in feedstuffs prices; there is a big interest in reducing the cost of feed globally. The use of multi-carbohydrase enzymes (MCE) to increase the nu
Externí odkaz:
https://doaj.org/article/068e6aef9afe4f73b1015087f5bf6c71
Autor:
Laura J. Smith, Arianna Skirzynska, Allysia A. Chin, Amy E. Arnold, Michelle Kushida, Peter B. Dirks, Molly S. Shoichet
Publikováno v:
ACS Materials Au, Vol 3, Iss 5, Pp 514-527 (2023)
Externí odkaz:
https://doaj.org/article/7d24600fbd74434a91b7c0e68b20103a
Autor:
Ana Nikolic, Francesca Maule, Anna Bobyn, Katrina Ellestad, Seungil Paik, Sajid A. Marhon, Parinaz Mehdipour, Xueqing Lun, Huey-Miin Chen, Claire Mallard, Alexander J. Hay, Michael J. Johnston, Christopher J. Gafuik, Franz J. Zemp, Yaoqing Shen, Nicoletta Ninkovic, Katalin Osz, Elodie Labit, N. Daniel Berger, Duncan K. Brownsey, John J. Kelly, Jeff Biernaskie, Peter B. Dirks, Darren J. Derksen, Steven J. M. Jones, Donna L. Senger, Jennifer A. Chan, Douglas J. Mahoney, Daniel D. De Carvalho, Marco Gallo
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-22 (2023)
Abstract Self-renewal is a crucial property of glioblastoma cells that is enabled by the choreographed functions of chromatin regulators and transcription factors. Identifying targetable epigenetic mechanisms of self-renewal could therefore represent
Externí odkaz:
https://doaj.org/article/028fa80da48448499589471060a20e19
Autor:
Akram A. Hamed, Daniel J. Kunz, Ibrahim El-Hamamy, Quang M. Trinh, Omar D. Subedar, Laura M. Richards, Warren Foltz, Garrett Bullivant, Matthaeus Ware, Maria C. Vladoiu, Jiao Zhang, Antony M. Raj, Trevor J. Pugh, Michael D. Taylor, Sarah A. Teichmann, Lincoln D. Stein, Benjamin D. Simons, Peter B. Dirks
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
The link between neural development and tumourigenesis in adult glioma remains unclear. Here, the authors monitor the developmental stages of Sox2 + /− stem cells from a mouse model using single-cell RNA sequencing and suggest the acquisition of em
Externí odkaz:
https://doaj.org/article/808d767b32b241cfad002bab2df3ad6b
Autor:
Ryan J. Smith, Hongpan Zhang, Shengen Shawn Hu, Theodora Yung, Roshane Francis, Lilian Lee, Mark W. Onaitis, Peter B. Dirks, Chongzhi Zang, Tae-Hee Kim
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
The primitive gut tube gives rise to all major internal organs, while underlying regulatory mechanisms are unclear. Here, the authors analyze its chromatin landscape at the single-cell level and define the epigenetic regulation of lineage fate decisi
Externí odkaz:
https://doaj.org/article/bcaab3d2355349bb944b03074f119683
Autor:
Cody Savage, Andrew T. Hale, Matthew S. Parr, Alexander Hedaya, Benjamin W. Saccomano, Georges Bouobda Tsemo, Muhammad U. Hafeez, Omar Tanweer, Peter Kan, Laurent J. Solomon, Dan Meila, Peter B. Dirks, Jeffrey P. Blount, James M. Johnston, Brandon G. Rocque, Curtis J. Rozzelle, Kartik Bhatia, Prakash Muthusami, Timo Krings, Jesse Jones
Publikováno v:
Frontiers in Pediatrics, Vol 10 (2022)
IntroductionUnderstanding outcomes after Vein of Galen malformation (VOGM) embolization has been limited by small sample size in reported series and predominantly single center studies. To address these limitations, we perform an individual-participa
Externí odkaz:
https://doaj.org/article/c2501b70589141799fb7c78dcb233bd4
Autor:
Lucy J. Brooks, Melanie P. Clements, Jemima J. Burden, Daniela Kocher, Luca Richards, Sara Castro Devesa, Leila Zakka, Megan Woodberry, Michael Ellis, Zane Jaunmuktane, Sebastian Brandner, Gillian Morrison, Steven M. Pollard, Peter B. Dirks, Samuel Marguerat, Simona Parrinello
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Glioma stem cells (GSCs) retain the ability to partially differentiate, but it is unclear how the brain microenvironment may influence this response. Here the authors show that glioblastoma cells infiltrating into the white matter acquire pre-oligode
Externí odkaz:
https://doaj.org/article/1dfd4c8671124520ac4d6ba779864aae
Autor:
Patty Sachamitr, Jolene C. Ho, Felipe E. Ciamponi, Wail Ba-Alawi, Fiona J. Coutinho, Paul Guilhamon, Michelle M. Kushida, Florence M. G. Cavalli, Lilian Lee, Naghmeh Rastegar, Victoria Vu, María Sánchez-Osuna, Jasmin Coulombe-Huntington, Evgeny Kanshin, Heather Whetstone, Mathieu Durand, Philippe Thibault, Kirsten Hart, Maria Mangos, Joseph Veyhl, Wenjun Chen, Nhat Tran, Bang-Chi Duong, Ahmed M. Aman, Xinghui Che, Xiaoyang Lan, Owen Whitley, Olga Zaslaver, Dalia Barsyte-Lovejoy, Laura M. Richards, Ian Restall, Amy Caudy, Hannes L. Röst, Zahid Quyoom Bonday, Mark Bernstein, Sunit Das, Michael D. Cusimano, Julian Spears, Gary D. Bader, Trevor J. Pugh, Mike Tyers, Mathieu Lupien, Benjamin Haibe-Kains, H. Artee Luchman, Samuel Weiss, Katlin B. Massirer, Panagiotis Prinos, Cheryl H. Arrowsmith, Peter B. Dirks
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
The arginine methyltransferase PRMT5 is over-expressed in cancer and has a role in the maintenance of stem cells. Here, the authors show that PRMT5 inhibitors can block the growth of patient derived glioblastoma stem cell cultures in vitro and in viv
Externí odkaz:
https://doaj.org/article/ce276d7ef43841fc91a953ffc3d02ecd
Autor:
Qin Wu, Wail ba-alawi, Genevieve Deblois, Jennifer Cruickshank, Shili Duan, Evelyne Lima-Fernandes, Jillian Haight, Seyed Ali Madani Tonekaboni, Anne-Marie Fortier, Hellen Kuasne, Trevor D. McKee, Hassan Mahmoud, Michelle Kushida, Sarina Cameron, Nergiz Dogan-Artun, WenJun Chen, Yan Nie, Lan Xin Zhang, Ravi N. Vellanki, Stanley Zhou, Panagiotis Prinos, Bradly G. Wouters, Peter B. Dirks, Susan J. Done, Morag Park, David W. Cescon, Benjamin Haibe-Kains, Mathieu Lupien, Cheryl H. Arrowsmith
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Triple negative breast cancer is a deadly form of breast cancer with limited therapeutic options. Here the authors show the efficacy of GLUT1 pharmacological inhibition against a subset of tumors expressing RB1, thereby identifying RB1 protein level
Externí odkaz:
https://doaj.org/article/130018a3112a40a29ff505012c3352a4