Zobrazeno 1 - 10
of 22
pro vyhledávání: '"P. Anthony Otero"'
Publikováno v:
Neurobiology of Disease, Vol 170, Iss , Pp 105768- (2022)
Perturbations of the endolysosomal pathway have been suggested to play an important role in the pathogenesis of several neurodegenerative diseases, including Parkinson's disease (PD) and Alzheimer's disease (AD). Specifically, VPS35 and the retromer
Externí odkaz:
https://doaj.org/article/7d94be93fe884227afd454d03fd354b7
Publikováno v:
Frontiers in Neuroscience, Vol 12 (2019)
There are currently no treatments that hinder or halt the inexorable progression of Parkinson’s disease (PD). While the etiology of PD remains elusive, evidence suggests that early dysfunction of mitochondrial respiration and homeostasis play a maj
Externí odkaz:
https://doaj.org/article/13c59150f21b4e96955ee292fcd4e4d3
Publikováno v:
Int Rev Mov Disord
International Review of Movement Disorders ISBN: 9780323899437
International Review of Movement Disorders ISBN: 9780323899437
PTEN-induced kinase 1 (PINK1) is a serine-threonine kinase in which mutations have been identified in patients with early-onset recessive Parkinson's disease. Since its discovery, PINK1 has been heavily studied in the context of mitochondrial dysfunc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::808fb73470aa09d8081fd0ee1083bf51
https://pubmed.ncbi.nlm.nih.gov/36035617
https://pubmed.ncbi.nlm.nih.gov/36035617
Autor:
Charleen T. Chu, Gabriella Fricklas, Aparna Nigam, Britney N. Lizama, Zachary P. Wills, Jon W. Johnson, P. Anthony Otero
Publikováno v:
The FASEB Journal. 36
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0f7f4df0a837474e48eadc9ef173780c
https://doi.org/10.1096/fasebj.2022.36.s1.r3427
https://doi.org/10.1096/fasebj.2022.36.s1.r3427
Publikováno v:
Neurobiol Dis
Perturbations of the endolysosomal pathway have been suggested to play an important role in the pathogenesis of several neurodegenerative diseases, including Parkinson’s disease (PD) and Alzheimer’s disease (AD). Specifically, VPS35 and the retro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d3ce9ebe381ce63f267d7851d8c0b65
https://pubmed.ncbi.nlm.nih.gov/35588987
https://pubmed.ncbi.nlm.nih.gov/35588987
Autor:
P. Anthony Otero, Gabriella Fricklas, Aparna Nigam, Britney N. Lizama, Zachary P Wills, Jon W. Johnson, Charleen T. Chu
Publikováno v:
J Neurosci
Mutations in PTEN-induced kinase 1 (PINK1) contribute to autosomal recessive Parkinson's disease with cognitive and neuropsychiatric comorbidities. Disturbances in dendritic and spine architecture are hallmarks of neurodegenerative and neuropsychiatr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59ab3244d2fe77532f6bfe2c9d2ceacc
https://doi.org/10.1523/jneurosci.0785-22.2022
https://doi.org/10.1523/jneurosci.0785-22.2022
Autor:
Matthew P. Weirich, Elizabeth C. Stahl, Madeleine P. Leek, Frances Alencastro, Evan R. Delgado, Whitney K. Brown, P. Anthony Otero, Nairita Roy, Maelee I. Chen, Patrick D. Wilkinson, Andrew W. Duncan
Publikováno v:
Hepatology. 69:1242-1258
The liver contains a mixture of hepatocytes with diploid or polyploid (tetraploid, octaploid, etc.) nuclear content. Polyploid hepatocytes are commonly found in adult mammals, representing ~90% of the entire hepatic pool in rodents. The cellular and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f790142804844eaffe0b08f53585a4e7
https://doi.org/10.1002/hep.30286
https://doi.org/10.1002/hep.30286
Autor:
Manish Verma, Nicholas W. Bateman, P. Anthony Otero, Nathaniel M. Weathington, Christine C. Wu, Erin Steer, Sarah R. Dunn, Rama K. Mallampalli, Charleen T. Chu, Bill B. Chen, Travis Lear, Alison C. McKelvey, Mauricio Rojas, Yuan Liu, Yu Jiang, Kent Z.Q. Wang
Publikováno v:
JCI Insight
Mitochondrial quality control is mediated by the PTEN-induced kinase 1 (PINK1), a cytoprotective protein that is dysregulated in inflammatory lung injury and neurodegenerative diseases. Here, we show that a ubiquitin E3 ligase receptor component, FBX
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87c41065d9222d07bf56725319d2e75d
https://doi.org/10.1172/jci.insight.131834
https://doi.org/10.1172/jci.insight.131834
Autor:
Madeleine P. Leek, P. Anthony Otero, Andrew W. Duncan, Michael Oertel, Matthew P. Weirich, Whitney K. Brown, Nairita Roy, Frances Alencastro, Patrick D. Wilkinson, Evan R. Delgado
Publikováno v:
Am J Pathol
The liver contains diploid and polyploid hepatocytes (tetraploid, octaploid, etc.), with polyploids comprising ≥90% of the hepatocyte population in adult mice. Polyploid hepatocytes form multipolar spindles in mitosis, which lead to chromosome gain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f2c80ef52db63a7c5e77e2962aec226
https://europepmc.org/articles/PMC6547059/
https://europepmc.org/articles/PMC6547059/
Autor:
Charleen T. Chu, Yi-Ping Hsueh, Yu-Tzu Shih, Nicholas W. Bateman, Kent Z.Q. Wang, Christine C. Wu, Erin Steer, P. Anthony Otero
Publikováno v:
The FASEB Journal. 33
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::55a6878df365f3cdb6826ca4d240259c
https://doi.org/10.1096/fasebj.2019.33.1_supplement.662.10
https://doi.org/10.1096/fasebj.2019.33.1_supplement.662.10