Zobrazeno 1 - 10
of 53
pro vyhledávání: '"P. Ann Boriack‐Sjodin"'
Autor:
Michael J Thomenius, Jennifer Totman, Darren Harvey, Lorna H Mitchell, Thomas V Riera, Kat Cosmopoulos, Alexandra R Grassian, Christine Klaus, Megan Foley, Elizabeth A Admirand, Haris Jahic, Christina Majer, Tim Wigle, Suzanne L Jacques, Jodi Gureasko, Dorothy Brach, Trupti Lingaraj, Kip West, Sherri Smith, Nathalie Rioux, Nigel J Waters, Cuyue Tang, Alejandra Raimondi, Michael Munchhof, James E Mills, Scott Ribich, Margaret Porter Scott, Kevin W Kuntz, William P Janzen, Mikel Moyer, Jesse J Smith, Richard Chesworth, Robert A Copeland, P Ann Boriack-Sjodin
Publikováno v:
PLoS ONE, Vol 13, Iss 6, p e0197372 (2018)
A key challenge in the development of precision medicine is defining the phenotypic consequences of pharmacological modulation of specific target macromolecules. To address this issue, a variety of genetic, molecular and chemical tools can be used. A
Externí odkaz:
https://doaj.org/article/8d24a066e3c44272bf8a8c8842bb3428
Autor:
Michael J Morrison, P Ann Boriack-Sjodin, Kerren K Swinger, Tim J Wigle, Dipti Sadalge, Kevin W Kuntz, Margaret Porter Scott, William P Janzen, Richard Chesworth, Kenneth W Duncan, Darren M Harvey, John W Lampe, Lorna H Mitchell, Robert A Copeland
Publikováno v:
PLoS ONE, Vol 13, Iss 5, p e0197082 (2018)
WHSC1 is a histone methyltransferase that is responsible for mono- and dimethylation of lysine 36 on histone H3 and has been implicated as a driver in a variety of hematological and solid tumors. Currently, there is a complete lack of validated chemi
Externí odkaz:
https://doaj.org/article/5a738d78cc0446bf85ca79bb119bc45d
Autor:
Jennifer Castro, Matthew H. Daniels, Chuang Lu, David Brennan, Deepali Gotur, Young-Tae Lee, Kevin Knockenhauer, April Case, Jie Wu, Shane M. Buker, Julie Liu, Brian A. Sparling, E. Allen Sickmier, Stephen J. Blakemore, P. Ann Boriack-Sjodin, Kenneth W. Duncan, Scott Ribich, Robert A. Copeland
Publikováno v:
Cancer Research. 83:1136-1136
DHX9 is a multifunctional DEAH-box ATP-independent RNA helicase which has been reported to play important roles in replication, transcription, translation, RNA splicing and RNA processing which contribute to DHX9’s role in maintenance of genomic st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fa8c337e484014a2fd0111880ff8a940
https://doi.org/10.1158/1538-7445.am2023-1136
https://doi.org/10.1158/1538-7445.am2023-1136
Autor:
P. Ann Boriack‐Sjodin
Publikováno v:
Structural Biology in Drug Discovery
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6715109c7f79c13494462f053a032316
https://doi.org/10.1002/9781118681121.ch18
https://doi.org/10.1002/9781118681121.ch18
Publikováno v:
Cell Chemical Biology. 25:128-134
A causal relationship between target activity modulation by small molecules and phenotypic consequence is the cornerstone of chemical biology and drug discovery. Here we articulate elements of translational chemical biology, as guideposts to ensure t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eecd48fa94a57fd75a8775f5ccc4f957
https://doi.org/10.1016/j.chembiol.2017.11.003
https://doi.org/10.1016/j.chembiol.2017.11.003
Autor:
Zachary A. Gurard-Levin, Scott Ribich, Jeffrey L Hirsch, Robert A. Copeland, Michael D. Scholle, Shane M Buker, April W. Case, P. Ann Boriack-Sjodin, Benjamin Wheeler
Publikováno v:
SLAS discovery : advancing life sciences RD. 25(4)
A variety of covalent modifications of RNA have been identified and demonstrated to affect RNA processing, stability, and translation. Methylation of adenosine at the N6 position (m6A) in messenger RNA (mRNA) is currently the most well-studied RNA mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aee775fada19705eccd80c63155e5be5
https://pubmed.ncbi.nlm.nih.gov/31585521
https://pubmed.ncbi.nlm.nih.gov/31585521
Publikováno v:
SLAS discovery : advancing life sciences RD. 24(5)
Contemporary chemical biology and drug discovery are increasingly focused on the discovery of inhibitory molecules that interact with enzyme targets in specific ways, such as allosteric or orthosteric binding. Hence, there is increasing interest in e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8c3e63ad9ad5c97d6e02ff3bebf41b4
https://pubmed.ncbi.nlm.nih.gov/30811960
https://pubmed.ncbi.nlm.nih.gov/30811960
Autor:
Buker, Shane M., Gurard-Levin, Zachary A., Wheeler, Benjamin D., Scholle, Michael D., Case, April W., Hirsch, Jeffrey L., Ribich, Scott, Copeland, Robert A., P. Ann Boriack-Sjodin
Supplemental material, Supplemental_Figures_Buker_etal_METTL3_Mass_Spec_Assay_20190701 for A Mass Spectrometric Assay of METTL3/METTL14 Methyltransferase Activity by Shane M. Buker, Zachary A. Gurard-Levin, Benjamin D. Wheeler, Michael D. Scholle, Ap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7847a7f8ca3aa9989d8dfcaf7e06c035
Autor:
Scott Ribich, Monique Laidlaw, Robert A. Copeland, April W. Case, Brian L. Hodous, E. Allen Sickmier, April E. Greene-Colozzi, Alexandra K. Gardino, Shane M Buker, Thomas Andrew Wynn, P. Ann Boriack-Sjodin
Publikováno v:
Molecular Cancer Therapeutics. 18:A112-A112
A variety of covalent modifications of and structural changes to RNA have been identified and demonstrated to affect RNA processing, stability and translation. The enzymes that catalyze these changes, RNA modifying proteins or RMPs, represent a large
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f79b81f3cd8ab2d2cea23b5492ab0c99
https://doi.org/10.1158/1535-7163.targ-19-a112
https://doi.org/10.1158/1535-7163.targ-19-a112
Autor:
Scott Ribich, Cindy Collins, Robert A. Copeland, P. Ann Boriack-Sjodin, Maureen S. Lynes, Alexandra K. Gardino
Publikováno v:
Molecular Cancer Therapeutics. 18:B130-B130
The deamination of adenosine to inosine (known as A-to-I editing) is one of the most prevalent RNA modifications that occurs in metazoans and is mediated by the Adenosine Deaminase Acting on RNA (ADAR) family of enzymes. The enzyme ADAR/ADAR1 catalyz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7539da9b9c4c349dff679c2ecdc7f2ca
https://doi.org/10.1158/1535-7163.targ-19-b130
https://doi.org/10.1158/1535-7163.targ-19-b130