Výsledky vyhledávání - "P. Andrew Karplus"

Akademický článek

A structural foundation for studying chlamydial polymorphic membrane proteins

Autor: Abigail M. Debrine, P. Andrew Karplus, Daniel D. Rockey

Publikováno v: Microbiology Spectrum, Vol 11, Iss 6 (2023)

ABSTRACT Polymorphic membrane proteins (Pmps) are chlamydial cell surface proteins with signature repeating FxxN and GGA (I, V, L) tetrapeptide motifs. These autotransporter proteins are key immune targets and mediators of host-microbe interactions b

Externí odkaz: https://doaj.org/article/17e17e65584a47e29e9714cf0d5f357a

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Akademický článek

Creating a Selective Nanobody Against 3-Nitrotyrosine Containing Proteins

Autor: Elise M. Van Fossen, Sonia Grutzius, Carl E. Ruby, Dan V. Mourich, Chris Cebra, Shay Bracha, P. Andrew Karplus, Richard B. Cooley, Ryan A. Mehl

Publikováno v: Frontiers in Chemistry, Vol 10 (2022)

A critical step in developing therapeutics for oxidative stress-related pathologies is the ability to determine which specific modified protein species are innocuous by-products of pathology and which are causative agents. To achieve this goal, techn

Externí odkaz: https://doaj.org/article/e7ee875dac2c4ee68361d8663535c867

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Akademický článek

Automated NMR resonance assignments and structure determination using a minimal set of 4D spectra

Autor: Thomas Evangelidis, Santrupti Nerli, Jiří Nováček, Andrew E. Brereton, P. Andrew Karplus, Rochelle R. Dotas, Vincenzo Venditti, Nikolaos G. Sgourakis, Konstantinos Tripsianes

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)

Further automation of NMR structure determination is needed to increase the throughput and accessibility of this method. Here the authors present 4D-CHAINS/autoNOE-Rosetta, a complete pipeline that allows rapid and fully automated structure determina

Externí odkaz: https://doaj.org/article/da44ac29a8c6451eba4c6afcde1322d3

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Akademický článek

The mitotic kinesin-14 KlpA contains a context-dependent directionality switch

Autor: Andrew R. Popchock, Kuo-Fu Tseng, Pan Wang, P. Andrew Karplus, Xin Xiang, Weihong Qiu

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-9 (2017)

Kinesin-14s are commonly considered to be minus end-directed microtubule motor proteins. Here the authors show that KlpA, a fungal kinesin-14 orthologue, relies on its N-terminal nonmotor microtubule-binding tail to achieve context-dependent bidirect

Externí odkaz: https://doaj.org/article/452fe2c9c270404e86830743dc6002c8

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Akademický článek

The Arg-Gly-Asp–Containing, Solvent-Exposed Loop of Ptr ToxA Is Required for Internalization

Autor: Viola A. Manning, Sara M. Hamilton, P. Andrew Karplus, Lynda M. Ciuffetti

Publikováno v: Molecular Plant-Microbe Interactions, Vol 21, Iss 3, Pp 315-325 (2008)

Internalization of the proteinaceous host-selective toxin, Ptr ToxA (ToxA), into sensitive wheat mesophyll cells is correlated with toxin activity. The solvent-exposed, Arg-Gly-Asp (RGD)-containing loop of ToxA is a candidate for interaction with the

Externí odkaz: https://doaj.org/article/e391da47583d4be09ec9692bd0115b9d

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