Case report: Donor lymphocyte infusion and blinatumomab as treatment for acute lymphoblastic leukemia relapse after allogeneic hematopoietic stem cell transplantation

Autor: Flavia Antonucci, Serena Marotta, Maria Celentano, Mariangela Pedata, Cira Riccardi, Cristina Luise, Angela Carobene, Simona Maria Muggianu, Assunta Viola, Mafalda Caputo, Stefania Leone, Ilaria Migliaccio, Barbara Pocali, Mirella Alberti, Claudio Falco, Mario Toriello, Felicetto Ferrara, Alessandra Picardi

Publikováno v: Frontiers in Hematology, Vol 3 (2024)

To date, the effect of blinatumomab and donor lymphocyte infusion association as a salvage treatment for acute lymphoblastic leukemia (ALL) relapse after allogeneic transplant procedure is still unknown. Here, we report a case report of a patient wit

Externí odkaz: https://doaj.org/article/696d4a34f3cc49e0827dfbf48df98890

Application of longitudinal item response theory models to modeling Parkinson’s disease progression

Autor: Haotian Zou, Varun Aggarwal, Glenn T. Stebbins, Martijn L. T. M. Müller, Jesse M. Cedarbaum, Anne Pedata, Diane Stephenson, Tanya Simuni, Sheng Luo

Publikováno v: CPT: Pharmacometrics & Systems Pharmacology, Vol 11, Iss 10, Pp 1382-1392 (2022)

Abstract The Movement Disorder Society revised version of the Unified Parkinson’s Disease Rating Scale (MDS‐UPDRS) parts 2 and 3 reflect patient‐reported functional impact and clinician‐reported severity of motor signs of Parkinson’s diseas

Externí odkaz: https://doaj.org/article/ee3e3e53b9774dd6a46eb395e7981514

Protective effects of carbonic anhydrase inhibition in brain ischaemia in vitro and in vivo models

Autor: Ilaria Dettori, Irene Fusco, Irene Bulli, Lisa Gaviano, Elisabetta Coppi, Federica Cherchi, Martina Venturini, Lorenzo Di Cesare Mannelli, Carla Ghelardini, Alessio Nocentini, Claudiu T. Supuran, Anna Maria Pugliese, Felicita Pedata

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 964-976 (2021)

Ischaemic stroke is a leading cause of death and disability. One of the major pathogenic mechanisms after ischaemia includes the switch to the glycolytic pathway, leading to tissue acidification. Carbonic anhydrase (CA) contributes to pH regulation.

Externí odkaz: https://doaj.org/article/b71f43961f06497bbcb2ac3275cfbddc

Volumetric MRI-Based Biomarkers in Huntington's Disease: An Evidentiary Review

Autor: Kirsi M. Kinnunen, Adam J. Schwarz, Emily C. Turner, Dorian Pustina, Emily C. Gantman, Mark F. Gordon, Richard Joules, Ariana P. Mullin, Rachael I. Scahill, Nellie Georgiou-Karistianis, The Huntington's Disease Regulatory Science Consortium (HD-RSC), Varun Aggarwal, Shazia Ali, Irina Antonijevic, Astri Arnesen, Nazem Atassi, Brian Beers, Beth Belluscio, Limor Ben Har, Angele Benard, Caroline Benn, Brian Bettencourt, Anu Bhattacharyya, Robi Blumenstein, Beth Borowsky, Bret Bostwick, Jackson Burton, Angelika Caputo, David Cooper, Brad Elmer, Rebecca Evans, Andrew Feigen, Terrence Fisher, Rebecca Fuller, Emily Gantman, Danielle Gartner, Michal Geva, Sandra Gonzalez, Adam Good, Mark Gordon, Jaya Goyal, Michael Hayden, Priyantha Herath, Steve Hersch, Jianying Hu, Elise Kayson, Eileen Koski, Bernhard Landwehrmeyer, Michelle Lax, Blair Leavitt, Dorothy Leong, Oren Levy, Enchi Liu, Jeff Long, Doug Macdonald, Jacqueline Major, Lahar Mehta, Tiago Mestre, Eric Miller, Christian Mueller, Catherine O'Riordan, Jennifer Panagoulias, Mike Panzara, Anne Pedata, Jennifer Petrillo-Billet, Dave Podskalny, Alisha Reader, Shelly Redman, Ralf Reilmann, Klaus Romero, Christopher Ross, Anne Rosser, Cristina Sampaio, Jan Samzelius, Scott Schobel, Adam Schwarz, Sudhir Sivakumaran, Jennie Socha, Glenn Stebbins, Julie Stout, Sarah Tabrizi, Emily Turner, Charles Venuto, Louise Vetter, Vissia Viglietta, Sarah Wahlstrom Helgren, Beth White, Ed Wild, George Yohrling, Maurice Zauderer

Publikováno v: Frontiers in Neurology, Vol 12 (2021)

Huntington's disease (HD) is an autosomal-dominant inherited neurodegenerative disorder that is caused by expansion of a CAG-repeat tract in the huntingtin gene and characterized by motor impairment, cognitive decline, and neuropsychiatric disturbanc

Externí odkaz: https://doaj.org/article/ca6c677056d045fbbeff255dc7be3a75

A2B Adenosine Receptors and Sphingosine 1-Phosphate Signaling Cross-Talk in Oligodendrogliogenesis

Autor: Elisabetta Coppi, Francesca Cencetti, Federica Cherchi, Martina Venturini, Chiara Donati, Paola Bruni, Felicita Pedata, Anna Maria Pugliese

Publikováno v: Frontiers in Neuroscience, Vol 15 (2021)

Oligodendrocyte-formed myelin sheaths allow fast synaptic transmission in the brain. Impairments in the process of myelination, or demyelinating insults, might cause chronic diseases such as multiple sclerosis (MS). Under physiological conditions, re

Externí odkaz: https://doaj.org/article/852d6731898b44a2a655cc441a16315e