Zobrazeno 1 - 10
of 48
pro vyhledávání: '"P. A. Abushik"'
Publikováno v:
СибСкрипт, Vol 25, Iss 5, Pp 687-695 (2023)
This empirical study links emotional burnout with self-attitude. The contemporary pedagogical environment subjects school teachers to emotional burnout and professional deformation. On the one hand, the state and society have extremely high professio
Externí odkaz:
https://doaj.org/article/365f34d55fad41778476330437c1022c
Autor:
Maria A. Ivanova, Arina D. Kokorina, Polina D. Timofeeva, Tatiana V. Karelina, Polina A. Abushik, Julia D. Stepanenko, Dmitry A. Sibarov, Sergei M. Antonov
Publikováno v:
Biomolecules, Vol 10, Iss 8, p 1104 (2020)
Pathological homocysteine (HCY) accumulation in the human plasma, known as hyperhomocysteinemia, exacerbates neurodegenerative diseases because, in the brain, this amino acid acts as a persistent N-methyl-d-aspartate receptor agonist. We studied the
Externí odkaz:
https://doaj.org/article/003048ff3e13413eafa7c87c47228e85
Autor:
Rashid Giniatullin, Irina Shelukhina, Nikita Mikhailov, Polina Abushik, Leniz Nurullin, Evgeny E. Nikolsky
Publikováno v:
Frontiers in Neurology, Vol 8 (2017)
BackgroundParasympathetic innervation of meninges and ability of carbachol, acetylcholine (ACh) receptor (AChR) agonist, to induce headaches suggests contribution of cholinergic mechanisms to primary headaches. However, neurochemical mechanisms of ch
Externí odkaz:
https://doaj.org/article/85a5180b253d44e99e2ff0411694ef95
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 10 (2016)
Homocysteine (HCY) is an endogenous redox active amino acid, best known as contributor to various neurodegenerative disorders. Although it is known that HCY can activate NMDA receptors (NMDARs), the mechanisms of its action on receptors composed of d
Externí odkaz:
https://doaj.org/article/43402539401f438cb15b463d6b68694b
Publikováno v:
Biophysics. 65:88-94
—Pathological changes in the cerebellum are often associated with dysfunction of Purkinje cells, which is manifested in excessive spike activity. In our experiments, the increase in the frequency of spike activity of Purkinje cells was caused by th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a2130bb27200d22a7ecc7634220ba331
https://doi.org/10.1134/s000635092001008x
https://doi.org/10.1134/s000635092001008x
Publikováno v:
Neuroscience and Behavioral Physiology. 50:115-118
Despite the fact that cultures of cerebellar granule cells constitute a popular experimental model, the key functional element of the cerebellum, i.e., Purkinje cells (PC), are rarely studied in tissue culture. There are currently serious methodologi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fed0f0b9d473c56ff6eb338af3a1cbac
https://doi.org/10.1007/s11055-019-00876-z
https://doi.org/10.1007/s11055-019-00876-z
Akademický článek
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Autor:
M. A. Ivanova, Sergei M. Antonov, T. V. Karelina, P. A. Abushik, L. S. Sitnikova, D. A. Sibarov
Publikováno v:
Neuroscience and Behavioral Physiology. 49:1096-1099
Activation of cyclic adenosine monophosphate (cAMP) synthesis is known to lead to triggering of neuroprotective signal cascades. It is therefore interesting to assess the effects of forskolin as an activator of adenylate cyclase and cAMP production o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c295b6fb4ad6d5f7f92d2fbcc016b0e5
https://doi.org/10.1007/s11055-019-00845-6
https://doi.org/10.1007/s11055-019-00845-6
Autor:
T. V. Karelina, P. A. Abushik, L. S. Sitnikova, Sergei M. Antonov, Yu. D. Stepanenko, Rashid Giniatullin, D. A. Sibarov, M. A. Ivanova
Publikováno v:
Biochemistry (Moscow), Supplement Series A: Membrane and Cell Biology. 12:360-368
Using fluorescence detection methods, neurotoxic effects of L-homocysteine (HCY), L-glutamate (Glu), and N-methyl-D-aspartate (NMDA) on primary culture of rat cerebellar neurons were compared and the agonist-evoked intracellular Ca2+ responses and ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2e243e1c467749ed56a82788db0f7bbb
https://doi.org/10.1134/s1990747818050069
https://doi.org/10.1134/s1990747818050069
Autor:
P. A. Abushik, Yu. D. Stepanenko, L. S. Sitnikova, D. A. Sibarov, M. A. Ivanova, T. V. Karelina, Sergei M. Antonov
Publikováno v:
Biochemistry (Moscow), Supplement Series A: Membrane and Cell Biology. 12:390-393
The analysis of neuronal viability of cerebellar neurons in primary culture during long-lasting (240 min) treatment with glutamate revealed that forskolin (1 μM), an adenylate cyclase activator, prevents apoptosis and necrosis of cells, thus exhibit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b42a29800f7a64f0fe7ca70601707810
https://doi.org/10.1134/s1990747818050021
https://doi.org/10.1134/s1990747818050021