Zobrazeno 1 - 10
of 121
pro vyhledávání: '"P. Relógio"'
Publikováno v:
EBioMedicine, Vol 110, Iss , Pp 105451- (2024)
Summary: The circadian clock, a fundamental cellular mechanism, regulates the rhythmic expression of numerous genes and biological processes across various organs. Disruptions in this system, driven by genetic or environmental factors, have been repo
Externí odkaz:
https://doaj.org/article/250b6ee6d621477d8c8e4818e1ecf8e5
Molecular mechanisms of tumour development in glioblastoma: an emerging role for the circadian clock
Autor:
Nina Nelson, Angela Relógio
Publikováno v:
npj Precision Oncology, Vol 8, Iss 1, Pp 1-18 (2024)
Abstract Glioblastoma is one of the most lethal cancers with current therapeutic options lacking major successes. This underlines the necessity to understand glioblastoma biology on other levels and use these learnings for the development of new ther
Externí odkaz:
https://doaj.org/article/62cba4ba92dd45448d1033baf1526248
Akademický článek
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Differential expression of the circadian clock network correlates with tumour progression in gliomas
Publikováno v:
BMC Medical Genomics, Vol 16, Iss 1, Pp 1-16 (2023)
Abstract Background Gliomas are tumours arising mostly from astrocytic or oligodendrocytic precursor cells. These tumours are classified according to the updated WHO classification from 2021 in 4 grades depending on molecular and histopathological cr
Externí odkaz:
https://doaj.org/article/1a54cd6f706d46e29d281f32d0b5b757
Publikováno v:
npj Systems Biology and Applications, Vol 9, Iss 1, Pp 1-12 (2023)
Abstract Increasing evidence points to a role of the circadian clock in the regulation of cancer hallmarks with a strong impact on the understanding and treatment of this disease. Anti-cancer treatment can be personalized considering treatment timing
Externí odkaz:
https://doaj.org/article/60441d35ee3b4756a1a1c4998f59af59
Skeletal muscle gene expression dysregulation in long-term spaceflights and aging is clock-dependent
Publikováno v:
npj Microgravity, Vol 9, Iss 1, Pp 1-20 (2023)
Abstract The circadian clock regulates cellular and molecular processes in mammals across all tissues including skeletal muscle, one of the largest organs in the human body. Dysregulated circadian rhythms are characteristic of aging and crewed spacef
Externí odkaz:
https://doaj.org/article/b2e28f74f50b4fcab79a8e3467d7bb2c
Publikováno v:
BMC Pediatrics, Vol 23, Iss 1, Pp 1-9 (2023)
Abstract Background In many organisms, including humans, the timing of cellular processes is regulated by the circadian clock. At the molecular level the core-clock consists of transcriptional-translational-feedback loops including several genes such
Externí odkaz:
https://doaj.org/article/82ea99a0d3c342358e62ed9b38dffd02
Publikováno v:
npj Systems Biology and Applications, Vol 8, Iss 1, Pp 1-17 (2022)
Abstract Emerging evidence points towards a regulatory role of the circadian clock in alternative splicing (AS). Whether alterations in core-clock components may contribute to differential AS events is largely unknown. To address this, we carried out
Externí odkaz:
https://doaj.org/article/34738d771b284b6eb58f43a2560c805b
Publikováno v:
Frontiers in Digital Health, Vol 5 (2023)
Circadian medicine, the study of the effects of time on health and disease has seen an uprising in recent years as a means to enhance health and performance, and optimize treatment timing. Our endogenous time generating system -the circadian clock- r
Externí odkaz:
https://doaj.org/article/560f3147d04f43c5a1d564c9b3db0aa8
Publikováno v:
EBioMedicine, Vol 89, Iss , Pp 104470- (2023)
Summary: Circadian rhythms regulate various processes in the human body, including drug metabolism. Chronotherapy optimizes treatment timing based on the circadian rhythm of the individual patient, such that the treatment efficacy is maximized, and a
Externí odkaz:
https://doaj.org/article/57583d701a064e6a87a029d9dba4d17e