Zobrazeno 1 - 10
of 55 404
pro vyhledávání: '"P-tau"'
Publikováno v:
IBRO Neuroscience Reports, Vol 17, Iss , Pp 423-430 (2024)
Introduction: Neurofibrillary tangles (NFTs) are composed of hyperphosphorylated forms of microtubule-associated protein tau (Tau), which is responsible for neurodegeneration in Alzheimer’s disease (AD). The hippocampal region has been a major focu
Externí odkaz:
https://doaj.org/article/b1ad43a822624b44b8a40b174895f499
Autor:
Branislav Kovacech, Nicholas C. Cullen, Petr Novak, Jozef Hanes, Eva Kontsekova, Stanislav Katina, Vojtech Parrak, Michal Fresser, Jeroen Vanbrabant, Howard H. Feldman, Bengt Winblad, Erik Stoops, Eugeen Vanmechelen, Norbert Zilka
Publikováno v:
Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-14 (2024)
Abstract Background The spread of tau pathology closely correlates with the disease course and cognitive decline in Alzheimer’s disease (AD). Tau-targeting immunotherapies are being developed to stop the spread of tau pathology and thus halt diseas
Externí odkaz:
https://doaj.org/article/181a7fda70974743b9f46a457e60777e
Autor:
Lee, Sang‐Eun, Park, Soomin, Kang, Rian, Lee, Taehoon, Yu, Won Jong, Chang, Sunghoe, Park, Jong‐Chan
Publikováno v:
FEBS Open Bio; Dec2024, Vol. 14 Issue 12, p2059-2071, 13p
Autor:
Cheng, Yu-Wen, Lin, Yen-Ju, Lin, Yung-Shuan, Hong, Wei-Pin, Kuan, Yi-Chun, Wu, Kuan-Yi, Hsu, Jung-Lung, Wang, Pei-Ning, Pai, Ming-Chyi, Chen, Cheng-Sheng, Fuh, Jong-Ling, Hu, Chaur-Jong, Chiu, Ming-Jang
Publikováno v:
Journal of the Formosan Medical Association; Dec2024, Vol. 123 Issue 12, p1210-1217, 8p
Publikováno v:
Biomédica: Revista del Instituto Nacional de Salud; dic2024, Vol. 44 Issue 4, p434-440, 7p
Autor:
Alexandra V. Sentyabreva, Olyesya A. Vasyukova, Yana A. Zorkina, Alisa V. Andryuschenko, Georgy P. Kostyuk, Irina Z. Eremina, Anna M. Kosyreva
Publikováno v:
RUDN Journal of Medicine, Vol 28, Iss 4, Pp 488-498 (2024)
Relevance. Alzheimer’s disease (AD) is the most cause of disability and dementia, which is the 7th leading cause of death worldwide. Diagnosis of AD includes detection of amyloid plaques and hyperphosphorylated tau protein (pTau) in the brain. Howe
Externí odkaz:
https://doaj.org/article/0f0c678ed60d4e1fbb2e0db4defb0f3b
Publikováno v:
Prion, Vol 18, Iss 1, Pp 1-10 (2024)
Fatal familial insomnia (FFI) is a rare autosomal dominant genetic neurodegenerative disease. Generally, FFI patients will develop rapidly progressive dementia, sleep disturbance, autonomic dysfunction, and so on. Cerebrospinal fluid examination of F
Externí odkaz:
https://doaj.org/article/0f347f476baf4a9c9e5e0697dac2b363
Publikováno v:
Ibrain, Vol 10, Iss 4, Pp 427-438 (2024)
Abstract Alzheimer's disease (AD) is a neurodegenerative disease, which is mainly characterized by the abnormal deposition of β‐amyloid peptide (Aβ) and Tau. Since Tau aggregation is more closely associated with synaptic loss, neurodegeneration,
Externí odkaz:
https://doaj.org/article/668505b2086045d4969388327b3a1faa
Autor:
Caio Bruno Q. S. Leal, Camila G. M. Zimmer, Vanessa V. C. Sinatti, Ericks S. Soares, Britt Poppe, Adrien Carton de Wiart, Xue Ying Chua, Ronan V. da Silva, Margaret H. Magdesian, Michael S. Rafii, Luc Buée, Rafael M. Bottos
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-17 (2024)
Abstract The U1 snRNP complex recognizes pre-mRNA splicing sites in the early stages of spliceosome assembly and suppresses premature cleavage and polyadenylation. Its dysfunction may precede Alzheimer’s disease (AD) hallmarks. Here we evaluated th
Externí odkaz:
https://doaj.org/article/f850433daa5a42ac92de4f0cdb44e0bf
Autor:
Sang‐Eun Lee, Soomin Park, Rian Kang, Taehoon Lee, Won Jong Yu, Sunghoe Chang, Jong‐Chan Park
Publikováno v:
FEBS Open Bio, Vol 14, Iss 12, Pp 2059-2071 (2024)
Alzheimer's disease (AD) is characterized by significant alterations in hippocampal function and structure, but the molecular mechanisms underlying the hippocampal region remain elusive. We integrated multiple transcriptome datasets including human o
Externí odkaz:
https://doaj.org/article/73f499f528064618938f904244468a15