Inhibition of P-glycoprotein: rapid assessment of its implication in blood-brain barrier integrity and drug transport to the brain by an in vitro model of the blood-brain barrier

Autor: Fenart, Laurence, Buée-Scherrer, Valérie, Descamps, Laurence, Duhem, Christian, Poullain, Marie-Gwenaëlle, Cecchelli, Roméo, Dehouck, Marie-Pierre

Publikováno v: Pharmaceutical Research
Pharmaceutical Research, American Association of Pharmaceutical Scientists, 1998, 15 (7), pp.993-1000. ⟨10.1023/a:1011913723928⟩
Pharmaceutical Research, 1998, 15 (7), pp.993-1000. ⟨10.1023/a:1011913723928⟩

International audience; Purpose. The objective of this work was to asses, in vitro, the passage of P-glycoprotein dependent drugs across brain capillary endothelial cells, when these drugs are associated with a reversing agents. Methods. An in vitro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::2abbda19f20682d1ee2aa3db16289ef9
https://hal-univ-artois.archives-ouvertes.fr/hal-00531737