Zobrazeno 1 - 10
of 134
pro vyhledávání: '"P-O. Johansson"'
Autor:
Ana C. Valencia-Olvera, Deebika Balu, Shreya Bellur, Thomas McNally, Yaseen Saleh, Don Pham, Shivesh Ghura, Jason York, Jan O. Johansson, Mary Jo LaDu, Leon Tai
Publikováno v:
Alzheimer’s Research & Therapy, Vol 15, Iss 1, Pp 1-16 (2023)
Abstract Background Alzheimer’s disease (AD) is characterized by cognitive dysfunction and amyloid plaques composed of the amyloid-beta peptide (Aβ). APOE is the greatest genetic risk for AD with APOE4 increasing risk up to ~ 15-fold compared to A
Externí odkaz:
https://doaj.org/article/f5241d90f3904145ab4ecaa3436a668b
Autor:
Sasan D. Noveir, Bilal E. Kerman, Haotian Xian, Cristiana Meuret, Sabrina Smadi, Ashley E. Martinez, Johannes Johansson, Henrik Zetterberg, Bryan A. Parks, Zsuzsanna Kuklenyik, Wendy J. Mack, Jan O. Johansson, Hussein N. Yassine
Publikováno v:
Alzheimer’s Research & Therapy, Vol 14, Iss 1, Pp 1-15 (2022)
Abstract Background Inducing brain ATP-binding cassette 1 (ABCA1) activity in Alzheimer’s disease (AD) mouse models is associated with improvement in AD pathology. The purpose of this study was to investigate the effects of the ABCA1 agonist peptid
Externí odkaz:
https://doaj.org/article/fc227b3fd34d459286120dcf7494e388
Autor:
Peter P. Toth, Gregory G. Schwartz, Stephen J. Nicholls, Aziz Khan, Michael Szarek, Henry N. Ginsberg, Jan O. Johansson, Kamyar Kalantar-Zadeh, Ewelina Kulikowski, Ken Lebioda, Norman C.W. Wong, Michael Sweeney, Kausik K. Ray
Publikováno v:
American Journal of Preventive Cardiology, Vol 11, Iss , Pp 100372- (2022)
Background: Nonalcoholic fatty liver disease (NAFLD) is common among patients with type 2 diabetes mellitus (T2DM) and is associated with increased risk for coronary atherosclerosis and acute cardiovascular (CV) events. We employed the validated, non
Externí odkaz:
https://doaj.org/article/291ad78b9b074af696eccafc0be2b3d5
Autor:
Dean Gilham, Sylwia Wasiak, Brooke D. Rakai, Li Fu, Laura M. Tsujikawa, Christopher D. Sarsons, Agostina Carestia, Kenneth Lebioda, Jan O. Johansson, Michael Sweeney, Kamyar Kalantar-Zadeh, Ewelina Kulikowski
Publikováno v:
Biomedicines, Vol 11, Iss 6, p 1663 (2023)
Epigenetic mechanisms are implicated in transcriptional programs driving chronic kidney disease (CKD). Apabetalone is an orally available inhibitor of bromodomain and extraterminal (BET) proteins, which are epigenetic readers that modulate gene expre
Externí odkaz:
https://doaj.org/article/5093b38d0a6348ee86b12a6a465daa75
Autor:
Gregory G. Schwartz, Stephen J. Nicholls, Peter P. Toth, Michael Sweeney, Christopher Halliday, Jan O. Johansson, Norman C. W. Wong, Ewelina Kulikowski, Kamyar Kalantar-Zadeh, Henry N. Ginsberg, Kausik K. Ray
Publikováno v:
Cardiovascular Diabetology, Vol 20, Iss 1, Pp 1-8 (2021)
Abstract Background In stable patients with type 2 diabetes (T2D), insulin treatment is associated with elevated risk for major adverse cardiovascular events (MACE). Patients with acute coronary syndrome (ACS) and T2D are at particularly high risk fo
Externí odkaz:
https://doaj.org/article/0d5fc1c61f3a4a028332f27e1c8614a5
Autor:
Laura M. Tsujikawa, Olesya A. Kharenko, Stephanie C. Stotz, Brooke D. Rakai, Christopher D. Sarsons, Dean Gilham, Sylwia Wasiak, Li Fu, Michael Sweeney, Jan O. Johansson, Norman C.W. Wong, Ewelina Kulikowski
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 152, Iss , Pp 113230- (2022)
Background: Bromodomain and extraterminal proteins (BETs) are more than just epigenetic regulators of transcription. Here we highlight a new role for the BET protein BRD4 in the maintenance of higher order chromatin structure at Topologically Associa
Externí odkaz:
https://doaj.org/article/8f4df9e6c3304f019c787cc9d257dbda
Autor:
Li Fu, Sylwia Wasiak, Laura M. Tsujikawa, Brooke D. Rakai, Stephanie C. Stotz, Norman C. W. Wong, Jan O. Johansson, Michael Sweeney, Connie M. Mohan, Aneal Khan, Ewelina Kulikowski
Publikováno v:
Pharmacology Research & Perspectives, Vol 10, Iss 3, Pp n/a-n/a (2022)
Abstract Fabry disease (FD) is a rare X‐linked disorder of lipid metabolism, characterized by the accumulation of globotriaosylceramide (Gb3) due to defective the lysosomal enzyme, α‐galactosidase. Gb3 deposits activate immune‐mediated systemi
Externí odkaz:
https://doaj.org/article/fcef1017fe6d4b528ebcb4c28defbc3c
Autor:
Stephen J. Nicholls, Gregory G. Schwartz, Kevin A. Buhr, Henry N. Ginsberg, Jan O. Johansson, Kamyar Kalantar-Zadeh, Ewelina Kulikowski, Peter P. Toth, Norman Wong, Michael Sweeney, Kausik K. Ray, the BETonMACE Investigators
Publikováno v:
Cardiovascular Diabetology, Vol 20, Iss 1, Pp 1-9 (2021)
Abstract Background Patients with diabetes and acute coronary syndrome (ACS) are at high risk for subsequent heart failure. Apabetalone is a selective inhibitor of bromodomain and extra-terminal (BET) proteins, epigenetic regulators of gene expressio
Externí odkaz:
https://doaj.org/article/f34be835c96248ac944527e1e1cc5d41
Autor:
Sylwia Wasiak, Dean Gilham, Emily Daze, Laura M. Tsujikawa, Christopher Halliday, Stephanie C. Stotz, Brooke D. Rakai, Li Fu, Ravi Jahagirdar, Michael Sweeney, Jan O. Johansson, Norman C. W. Wong, Ewelina Kulikowski
Publikováno v:
Cardiovascular Therapeutics, Vol 2020 (2020)
Chronic systemic inflammation contributes to cardiovascular disease (CVD) and correlates with the abundance of acute phase response (APR) proteins in the liver and plasma. Bromodomain and extraterminal (BET) proteins are epigenetic readers that regul
Externí odkaz:
https://doaj.org/article/f51d93da11054162b5cd4b953f4b5169
Autor:
Sylwia Wasiak, Laura M. Tsujikawa, Christopher Halliday, Stephanie C. Stotz, Dean Gilham, Ravi Jahagirdar, Kamyar Kalantar-Zadeh, Richard Robson, Michael Sweeney, Jan O. Johansson, Norman C. Wong, Ewelina Kulikowski
Publikováno v:
Kidney International Reports, Vol 3, Iss 3, Pp 711-721 (2018)
Introduction: Apabetalone, a small molecule inhibitor, targets epigenetic readers termed BET proteins that contribute to gene dysregulation in human disorders. Apabetalone has in vitro and in vivo anti-inflammatory and antiatherosclerotic properties.
Externí odkaz:
https://doaj.org/article/2137257e12454054b0edb1bd9ba53d1e