Výsledky vyhledávání - "P-Glycoprotein/metabolism"

The role of ABC transporters in protecting cells from bilirubin toxicity

Autor: Claudio Tiribelli, Cristina Bellarosa, Giulia Bortolussi

Publikováno v: Current pharmaceutical design. 15(25)

The ATP-Binding Cassette (ABC) superfamily is the largest transporter family known to translocate a wide variety of exogenous and endogenous substrates across cell membranes. In this chapter we review the potential role of three ABC proteins in the t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a973ec4bf2ac8dae526acd1b5e31e3d7
https://pubmed.ncbi.nlm.nih.gov/19754365

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Simultaneous LC-MS/MS quantification of P-glycoprotein and cytochrome P450 probe substrates and their metabolites in DBS and plasma

Autor: Marija Bosilkovska, Julien Déglon, Caroline Samer, Bernhard Walder, Jules Desmeules, Christian Staub, Youssef Daali

Publikováno v: Bioanalysis, Vol. 6, No 2 (2014) pp. 151-64

Background: An LC–MS/MS method has been developed for the simultaneous quantification of P-glycoprotein (P-gp) and cytochrome P450 (CYP) probe substrates and their Phase I metabolites in DBS and plasma. P-gp (fexofenadine) and CYP-specific substrat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::823f87e425da750fe7eb01110c590f69
https://archive-ouverte.unige.ch/unige:43679

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Differential expression of the multidrug resistance-related proteins ABCb1 and ABCc1 between blood-brain interfaces

Autor: Jean-François Ghersi-Egea, J. Donald Ostrow, Nathalie Strazielle, Claudio Tiribelli, Charlotte Schmitt, Silvia Gazzin, Michelle Fèvre-Montange

Publikováno v: The Journal of comparative neurology. 510(5)

Cerebral homeostasis results from the presence of the protective blood-brain and blood-cerebrospinal fluid barriers located respectively at the brain capillary endothelium and the choroid plexus epithelium. ABCb1 (Pgp) and ABCc1 (Mrp1) transporters a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37be2f06ee102ed2e228caebfc900fea
https://pubmed.ncbi.nlm.nih.gov/18680196

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Role of P-glycoprotein in the uptake/efflux transport of oral vitamin K antagonists and rivaroxaban through the Caco-2 cell model

Autor: Victoria Rollason, Pascal Bonnabry, Youssef Daali, Liliane Gschwind, Jules Alexandre Desmeules, Pierre Dayer

Publikováno v: Basic & Clinical Pharmacology & Toxicology, Vol. 113, No 4 (2013) pp. 259-265

Vitamin K antagonists (VKAs) are prescribed worldwide and remain the oral anticoagulant of choice. These drugs are characterized by a narrow therapeutic index and a large inter- and intra-individual variability. P-glycoprotein could contribute to thi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ef277b5f23b57515df1d93c4c94577a
https://archive-ouverte.unige.ch/unige:43534

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Allongement de l'espace QT et inhibition de la glycoprotéine P : à propos de deux observations gériatriques

Autor: Boillat, Dominique, Falconnet, Catherine, Vogt-Ferrier, Nicole Barbara

Publikováno v: Revue médicale suisse, Vol. 1, No 39 (2005) pp. 2527-2532

Two cases with QT prolongation associated with the administration of standard drug doses are reported. Drug effects are determined by pharmacological and biological parameters. Drugs may be metabolized or transported by two systems: the cytochrome en

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https://archive-ouverte.unige.ch/unige:86978

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