Zobrazeno 1 - 10
of 41
pro vyhledávání: '"P W, Stacpoole"'
Autor:
David O. Kamson, Viveka Chinnasamy, Stuart A. Grossman, Chetan Bettegowda, Peter B. Barker, Peter W. Stacpoole, Georg Oeltzschner
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
The adverse effects of lactic acidosis in the cancer microenvironment have been increasingly recognized. Dichloroacetate (DCA) is an orally bioavailable, blood brain barrier penetrable drug that has been extensively studied in the treatment of mitoch
Externí odkaz:
https://doaj.org/article/51eac7b3710246fe9d1c769f082fc196
Autor:
Tae Seok Oh, Manal Zabalawi, Shalini Jain, David Long, Peter W. Stacpoole, Charles E. McCall, Matthew A. Quinn
Publikováno v:
JCI Insight, Vol 7, Iss 12 (2022)
Sepsis is a life-threatening organ dysfunction caused by dysregulated host response to an infection. The metabolic aberrations associated with sepsis underly an acute and organism-wide hyperinflammatory response and multiple organ dysfunction; howeve
Externí odkaz:
https://doaj.org/article/5d981fcaf4444ba598df155e5fb19c2a
Autor:
Rabina Mainali, Manal Zabalawi, David Long, Nancy Buechler, Ellen Quillen, Chia-Chi Key, Xuewei Zhu, John S Parks, Cristina Furdui, Peter W Stacpoole, Jennifer Martinez, Charles E McCall, Matthew A Quinn
Publikováno v:
eLife, Vol 10 (2021)
Metabolic reprogramming between resistance and tolerance occurs within the immune system in response to sepsis. While metabolic tissues such as the liver are subjected to damage during sepsis, how their metabolic and energy reprogramming ensures surv
Externí odkaz:
https://doaj.org/article/54dd853ae26241009d6cb06d0d6d3a95
Publikováno v:
Journal of Lipid Research, Vol 39, Iss 2, Pp 388-401 (1998)
The effect on apolipoprotein B kinetics of a diet enriched in either fish oil or safflower oil was investigated in five hypertriglyceridemic (HTG), non-insulin-dependent diabetic subjects. The fish oil diet decreased plasma triglycerides and VLDL-apo
Externí odkaz:
https://doaj.org/article/061daf0c447a44578f2c52c2cf489a21
Autor:
Jesse F Gregory, Youngja Park, Yvonne Lamers, Nirmalya Bandyopadhyay, Yueh-Yun Chi, Kichen Lee, Steven Kim, Vanessa da Silva, Nikolas Hove, Sanjay Ranka, Tamer Kahveci, Keith E Muller, Robert D Stevens, Christopher B Newgard, Peter W Stacpoole, Dean P Jones
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e63544 (2013)
Marginal deficiency of vitamin B-6 is common among segments of the population worldwide. Because pyridoxal 5'-phosphate (PLP) serves as a coenzyme in the metabolism of amino acids, carbohydrates, organic acids, and neurotransmitters, as well as in as
Externí odkaz:
https://doaj.org/article/a4d251589e4f428ab4dda7dc474ccecb
Autor:
W R Fisher, V Venkatakrishnan, L A Zech, C M Hall, L L Kilgore, P W Stacpoole, M R Diffenderfer, K E Friday, A E Sumner, J B Marsh
Publikováno v:
Journal of Lipid Research, Vol 36, Iss 7, Pp 1618-1628 (1995)
The kinetics of apolipoproteins A-I and A-II were examined in human subjects using leucine tracers administered intravenously. High density lipoproteins were separated and apoA-I and A-II were isolated. The specific activity or enrichment data for th
Externí odkaz:
https://doaj.org/article/9b46670b53a249ddb0b67d9d1efa0eea
Autor:
B Cheng, C Ling, Y Dai, Y Lu, L G Glushakova, S W Y Gee, K E McGoogan, G V Aslanidi, M Park, P W Stacpoole, D Siemann, C Liu, A Srivastava
Publikováno v:
Gene therapy
Our recent studies have revealed that among the 10 different commonly used adeno-associated virus (AAV) serotypes, AAV3 vectors transduce human liver cancer cells extremely efficiently because these cells express high levels of human hepatocyte growt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bce9369f87490b8da0f94c97efb383e8
http://europepmc.org/articles/PMC3519243
http://europepmc.org/articles/PMC3519243
Publikováno v:
Journal of Lipid Research, Vol 25, Iss 9, Pp 967-978 (1984)
Methods were developed for determination of microsomal HMG-CoA reductase activity from freshly isolated human lymphocytes, monocytes, and granulocytes or cultured human lymphoid cells. Reductase activity in monocytes is approximately twice that in ly
Externí odkaz:
https://doaj.org/article/2e094e336e0d4b36bec52b5340a8cb95
Publikováno v:
Journal of Lipid Research, Vol 28, Iss 3, Pp 292-304 (1987)
Methods were developed for determination of human mononuclear leukocyte HMG-CoA reductase protein concentration by a noncompetitive, solid phase, bridged biotin-avidin enzyme immunoassay procedure. Leukocyte microsomal HMG-CoA reductase, first immobi
Externí odkaz:
https://doaj.org/article/9b97b2ee708740238fe873f31a00f7f5
Autor:
P W, Stacpoole, Y J, Greene
Publikováno v:
Diabetes Care. 15:785-791
Dichloroacetate (DCA) represents a potentially novel class of oral antidiabetic agents that reduce blood glucose and lipids without stimulating insulin secretion. DCA reduces blood glucose by inhibiting hepatic glucose synthesis and stimulating gluco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6d99ab62c143aad4175eef959a181ce
https://doi.org/10.2337/diacare.15.6.785
https://doi.org/10.2337/diacare.15.6.785