Zobrazeno 1 - 10
of 25
pro vyhledávání: '"P W, Rodgers"'
Autor:
Sowmya Madabushi, K Martin Chow, Eun Suk Song, Anwesha Goswami, Louis B Hersh, David W Rodgers
Publikováno v:
PLoS ONE, Vol 18, Iss 7, p e0287086 (2023)
Puromycin-sensitive aminopeptidase (E.C. 3.4.11.14, UniProt P55786), a zinc metallopeptidase belonging to the M1 family, degrades a number of bioactive peptides as well as peptides released from the proteasome, including polyglutamine. We report the
Externí odkaz:
https://doaj.org/article/3b2f3daab1ff45f786b376cc55adf2b0
Publikováno v:
Frontiers in Energy Research, Vol 8 (2020)
Ionic liquids (ILs) are organic salts molten at room temperature that can be used for a wide variety of applications. Many ILs, such as 1-ethyl-3-methylimidazolium acetate ([C2C1Im][OAc]), have been shown to remove a significant fraction of the compl
Externí odkaz:
https://doaj.org/article/586f6b3867b847be96e4bdcaf667c819
Publikováno v:
Advances in Civil Engineering, Vol 2019 (2019)
Recent research on supplemental damping enabling low to no damage structures has led to new devices, such as lead-extrusion-based high force-to-volume (HF2V) devices. They provide significant energy dissipation and force capacity in a small volume, e
Externí odkaz:
https://doaj.org/article/31fa03cdec3f477b9431a2cc2754c7f1
Publikováno v:
Advances in Civil Engineering, Vol 2016 (2016)
Base flexibility of structures changes and can increase the demands on structural elements during earthquake excitation. Such flexibility may come from the base connection, foundation, and soil under the foundation. This research evaluates the effect
Externí odkaz:
https://doaj.org/article/cf8d3c5b12804259a3be60092bf091cf
Publikováno v:
Frontiers in Neural Circuits, Vol 9 (2015)
Experimental and computational studies demonstrate that different sets of intrinsic and synaptic conductances can give rise to equivalent activity patterns. This is because the balance of conductances, not their absolute values, defines a given activ
Externí odkaz:
https://doaj.org/article/619f9ddc92834dd09f527de4534f31b3
Publikováno v:
PLoS ONE, Vol 10, Iss 2, p e0117965 (2015)
Volume transmission results in phasic and tonic modulatory signals. The actions of tonic dopamine (DA) at type 1 DA receptors (D1Rs) are largely undefined. Here we show that tonic 5nM DA acts at D1Rs to stabilize neuronal output over minutes by enabl
Externí odkaz:
https://doaj.org/article/1192747609b74375838c3e77d73689b4
Publikováno v:
Shock and Vibration, Vol 2015 (2015)
This paper presents a health monitoring method using measured hysteretic responses. Acceleration and infrequently measured displacement are integrated using a multirate Kalman filtering method to generate restoring force-displacement hysteresis loops
Externí odkaz:
https://doaj.org/article/ae75931c342140c8a0529b6a608149aa
Autor:
Eun Suk Song, Mehmet Ozbil, Tingting Zhang, Michael Sheetz, David Lee, Danny Tran, Sheng Li, Rajeev Prabhakar, Louis B Hersh, David W Rodgers
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0133114 (2015)
Insulin degrading enzyme (IDE) is believed to be the major enzyme that metabolizes insulin and has been implicated in the degradation of a number of other bioactive peptides, including amyloid beta peptide (Aβ), glucagon, amylin, and atrial natriure
Externí odkaz:
https://doaj.org/article/fcf1549bd80741afb483d1fb90bf33e4
Autor:
Eun Suk Song, Manana Melikishvili, Michael G Fried, Maria A Juliano, Luiz Juliano, David W Rodgers, Louis B Hersh
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e46790 (2012)
Cysteine residues in insulin degrading enzyme have been reported as non-critical for its activity. We found that converting the twelve cysteine residues in rat insulin degrading enzyme (IDE) to serines resulted in a cysteine-free form of the enzyme w
Externí odkaz:
https://doaj.org/article/96dae104c9384c608ee2aae9d12520ab
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e32343 (2012)
Neprilysin (NEP), a member of the M13 subgroup of the zinc-dependent endopeptidase family is a membrane bound peptidase capable of cleaving a variety of physiological peptides. We have generated a series of neprilysin variants containing mutations at
Externí odkaz:
https://doaj.org/article/3023f23b3ef247ecab3c17d1a7c9c1b8