Zobrazeno 1 - 10
of 30
pro vyhledávání: '"P W, Reeh"'
Autor:
Tal Hoffmann, Florian Klemm, Tatjana I Kichko, Susanne K Sauer, Katrin Kistner, Bernhard Riedl, Patrick Raboisson, Lei Luo, Alexandru Babes, Laurence Kocher, Giancarlo Carli, Michael J. M. Fischer, Peter W. Reeh
Publikováno v:
Physiological Reports, Vol 10, Iss 6, Pp n/a-n/a (2022)
Abstract The most widely used formalin test to screen antinociceptive drug candidates is still apostrophized as targeting inflammatory pain, in spite of strong opposing evidence published. In our rat skin‐nerve preparation ex vivo, recording from a
Externí odkaz:
https://doaj.org/article/1914070659d6462b8e34932dd1b49f99
Autor:
Beatrice Oehler, Katrin Kistner, Corinna Martin, Jürgen Schiller, Rafaela Mayer, Milad Mohammadi, Reine-Solange Sauer, Milos R. Filipovic, Francisco R. Nieto, Jan Kloka, Diana Pflücke, Kerstin Hill, Michael Schaefer, Marzia Malcangio, Peter W. Reeh, Alexander Brack, Robert Blum, Heike L. Rittner
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-22 (2017)
Abstract Phospholipids occurring in cell membranes and lipoproteins are converted into oxidized phospholipids (OxPL) by oxidative stress promoting atherosclerotic plaque formation. Here, OxPL were characterized as novel targets in acute and chronic i
Externí odkaz:
https://doaj.org/article/a6c20966bd864799baf52d5a980c648e
Autor:
Andreas Klusch, Christian Gorzelanny, Peter W Reeh, Martin Schmelz, Marlen Petersen, Susanne K Sauer
Publikováno v:
PLoS ONE, Vol 13, Iss 9, p e0203215 (2018)
Nerve terminals of primary sensory neurons are influenced by their environment through target derived trophic factors, like nerve growth factor (NGF) or glial cell line-derived neurotrophic factor (GDNF). In mice, subpopulations of DRG neurons expres
Externí odkaz:
https://doaj.org/article/b5827199f3444f3b95b19f0fe4df00d3
Autor:
Mirjam Eberhardt, Thomas Stueber, Jeanne de la Roche, Christine Herzog, Andreas Leffler, Peter W Reeh, Katrin Kistner
Publikováno v:
PLoS ONE, Vol 12, Iss 11, p e0188008 (2017)
Local anaesthetics (LA) reduce neuronal excitability by inhibiting voltage-gated Na+ channels. When applied at high concentrations in the direct vicinity of nerves, LAs can also induce relevant irritation and neurotoxicity via mechanisms involving an
Externí odkaz:
https://doaj.org/article/7d964d25ebad4405bf43251533744240
Autor:
Sonja M Mueller-Tribbensee, Manoj Karna, Mohammad Khalil, Markus F Neurath, Peter W Reeh, Matthias A Engel
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0128242 (2015)
BackgroundVarious transient receptor potential (TRP) channels in sensory neurons contribute to the transduction of mechanical stimuli in the colon. Recently, even the cold-sensing menthol receptor TRPM(melastatin)8 was suggested to be involved in mur
Externí odkaz:
https://doaj.org/article/511ae37c5e6045aca109786c0ef389a6
Autor:
Michael J M Fischer, Kailey J Soller, Susanne K Sauer, Joanna Kalucka, Gianluigi Veglia, Peter W Reeh
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0123762 (2015)
The formalin test is the most widely used behavioral screening test for analgesic compounds. The cellular mechanism of action of formaldehyde, inducing a typically biphasic pain-related behavior in rodents is addressed in this study. The chemorecepto
Externí odkaz:
https://doaj.org/article/a2b6316d12a94b7da6cc901d34da7dd0
Autor:
Filip Touska, Simon Sattler, Philipp Malsch, Richard J. Lewis, Peter W. Reeh, Katharina Zimmermann
Publikováno v:
Marine Drugs, Vol 15, Iss 9, p 269 (2017)
Ciguatoxins (CTXs) are marine toxins that cause ciguatera fish poisoning, a debilitating disease dominated by sensory and neurological disturbances that include cold allodynia and various painful symptoms as well as long-lasting pruritus. Although CT
Externí odkaz:
https://doaj.org/article/c790d2117c97485983307e7febafc33e
Autor:
T, Hoffmann, K, Kistner, F, Miermeister, R, Winkelmann, J, Wittmann, M J M, Fischer, C, Weidner, P W, Reeh
Publikováno v:
European journal of pain (London, England). 17(10)
Two transient receptor potential (TRP) channels, TRPV1 and TRPA1, have been physiologically studied with regard to noxious heat transduction. Evidence argues against these channels as sole transducers of noxious heat or cold, respectively. Moreover,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c841b34829eea951ecaf7dca7761970a
https://pubmed.ncbi.nlm.nih.gov/23720338
https://pubmed.ncbi.nlm.nih.gov/23720338
Autor:
C, Brenneis, K, Kistner, M, Puopolo, S, Jo, Dp, Roberson, M, Sisignano, D, Segal, E J, Cobos, B J, Wainger, S, Labocha, N, Ferreirós, C, von Hehn, J, Tran, G, Geisslinger, P W, Reeh, B P, Bean, C J, Woolf
Publikováno v:
British journal of pharmacology. 171(2)
Selective nociceptor fibre block is achieved by introducing the cell membrane impermeant sodium channel blocker lidocaine N-ethyl bromide (QX-314) through transient receptor potential V1 (TRPV1) channels into nociceptors. We screened local anaestheti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c9034bd839ad0ec92591316879db82ca
https://pubmed.ncbi.nlm.nih.gov/24117225
https://pubmed.ncbi.nlm.nih.gov/24117225
Publikováno v:
Pain. 62:87-94
On the premises of clinical studies, a possible contribution of oxygen radicals has been considered to the development of inflammatory pain and hyperalgesia. In a rat skin-saphenous nerve preparation using standard teased-fiber techniques (n = 57) hy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52bdcbb49d9dd0e02c9cdd4552e5a1d0
https://doi.org/10.1016/0304-3959(94)00254-c
https://doi.org/10.1016/0304-3959(94)00254-c