Zobrazeno 1 - 10
of 303
pro vyhledávání: '"P W, Mathieson"'
Autor:
J. A. Hurcombe, P. Hartley, A. C. Lay, L. Ni, J. J. Bedford, J. P. Leader, S. Singh, A. Murphy, C. L. Scudamore, E. Marquez, A. F. Barrington, V. Pinto, M. Marchetti, L.-F. Wong, J. Uney, M. A. Saleem, P. W. Mathieson, S. Patel, R. J. Walker, J. R. Woodgett, S. E. Quaggin, G. I. Welsh, R. J. M. Coward
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Glycogen Synthase Kinase 3 (GSK3) has conserved functions across species but its role in the kidney is unclear. Here, the authors show that in the kidney podocyte cell of mice and related nephrocyte in Drosophila that GSK3 is a master regulator of fu
Externí odkaz:
https://doaj.org/article/051986d29ba44b0d9f2cf3bc9a46a0bb
Autor:
Olivia May, Nicolas S. Merle, Anne Grunenwald, Viviane Gnemmi, Juliette Leon, Cloé Payet, Tania Robe-Rybkine, Romain Paule, Florian Delguste, Simon C. Satchell, Peter W. Mathieson, Marc Hazzan, Eric Boulanger, Jordan D. Dimitrov, Veronique Fremeaux-Bacchi, Marie Frimat, Lubka T. Roumenina
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Atypical hemolytic uremic syndrome (aHUS) is a severe disease characterized by microvascular endothelial cell (EC) lesions leading to thrombi formation, mechanical hemolysis and organ failure, predominantly renal. Complement system overactivation is
Externí odkaz:
https://doaj.org/article/ab3a68c47e3c4970883cff46cc2fc1af
Akademický článek
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Akademický článek
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Autor:
Xiqian Lan, Partab Rai, Nirupama Chandel, Kang Cheng, Rivka Lederman, Moin A Saleem, Peter W Mathieson, Mohammad Husain, John T Crosson, Kalpna Gupta, Ashwani Malhotra, Pravin C Singhal
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e55748 (2013)
Morphine has been reported to accelerate the progression of chronic kidney disease. However, whether morphine affects slit diaphragm (SD), the major constituent of glomerular filtration barrier, is still unclear. In the present study, we examined the
Externí odkaz:
https://doaj.org/article/58f10f5c3ef1429cb4a2635bcdbe0a2d
Autor:
Anurag Singh, Raina D Ramnath, Rebecca R Foster, Emma C Wylie, Vincent Fridén, Ishita Dasgupta, Borje Haraldsson, Gavin I Welsh, Peter W Mathieson, Simon C Satchell
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e55852 (2013)
Reactive oxygen species (ROS) play a key role in the pathogenesis of proteinuria in glomerular diseases like diabetic nephropathy. Glomerular endothelial cell (GEnC) glycocalyx covers the luminal aspect of the glomerular capillary wall and makes an i
Externí odkaz:
https://doaj.org/article/e52a8bf16aad419c8cdf3553c65726ed
Autor:
Claire Rigothier, Patrick Auguste, Gavin I Welsh, Sébastien Lepreux, Colette Deminière, Peter W Mathieson, Moin A Saleem, Jean Ripoche, Christian Combe
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e37695 (2012)
IQGAP1 is a scaffold protein that interacts with proteins of the cytoskeleton and the intercellular adhesion complex. In podocytes, IQGAP1 is associated with nephrin in the glomerular slit diaphragm (SD) complex, but its role remains ill-defined. In
Externí odkaz:
https://doaj.org/article/ff2458d3cafa4b1f939990839a289e63
Autor:
Thaneas Prabakaran, Rikke Nielsen, Simon C Satchell, Peter W Mathieson, Ulla Feldt-Rasmussen, Søren S Sørensen, Erik I Christensen
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e39975 (2012)
Prominent vasculopathy in Fabry disease patients is caused by excessive intracellular accumulation of globotriaosylceramide (GL-3) throughout the vascular endothelial cells causing progressive cerebrovascular, cardiac and renal impairments. The vascu
Externí odkaz:
https://doaj.org/article/9466320645a544d28b7ef843124789d0
Autor:
Sadie C Slater, Vince Beachley, Thomas Hayes, Daming Zhang, Gavin I Welsh, Moin A Saleem, Peter W Mathieson, Xuejun Wen, Bo Su, Simon C Satchell
Publikováno v:
PLoS ONE, Vol 6, Iss 6, p e20802 (2011)
The filtering unit of the kidney, the glomerulus, contains capillaries whose walls function as a biological sieve, the glomerular filtration barrier. This comprises layers of two specialised cells, glomerular endothelial cells (GEnC) and podocytes, s
Externí odkaz:
https://doaj.org/article/0dbab7e3d6a14be998f4fc9d45c15212
Akademický článek
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