Zobrazeno 1 - 10
of 51
pro vyhledávání: '"P W, Kuchel"'
Autor:
Xinyu Wu, Margareta Go, Julie V. Nguyen, Nathan W. Kuchel, Bernadine G. C. Lu, Kathleen Zeglinski, Kym N. Lowes, Dale J. Calleja, Jeffrey P. Mitchell, Guillaume Lessene, David Komander, Matthew E. Call, Melissa J. Call
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Papain-like protease (PLpro) is an attractive drug target for SARS-CoV-2 because it is essential for viral replication, cleaving viral poly-proteins pp1a and pp1ab, and has de-ubiquitylation and de-ISGylation activities, affecting innate imm
Externí odkaz:
https://doaj.org/article/f2aa5295a8ff4f9095605b082b38d19a
Autor:
Aidan M. Michaels, Anna Zoccarato, Zoe Hoare, George Firth, Yu Jin Chung, Philip W. Kuchel, Ajay M. Shah, Michael J. Shattock, Richard Southworth, Thomas R. Eykyn
Publikováno v:
Cancer & Metabolism, Vol 12, Iss 1, Pp 1-16 (2024)
Abstract Background Glycolytic flux is regulated by the energy demands of the cell. Upregulated glycolysis in cancer cells may therefore result from increased demand for adenosine triphosphate (ATP), however it is unknown what this extra ATP turnover
Externí odkaz:
https://doaj.org/article/61fe531d26c740f2a46c9ccc1181bfa7
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Whether GPCRs support the sensing of temperature as well as other chemical and physical modalities is not well understood.Introduction: Extracellular Ca2+ concentration (Ca2+o) modulates core body temperature and the firing rates of temperature-sensi
Externí odkaz:
https://doaj.org/article/63ac0407228d4dccbd2f2b5d3d3022e6
Modified N-linked glycosylation status predicts trafficking defective human Piezo1 channel mutations
Autor:
Jinyuan Vero Li, Chai-Ann Ng, Delfine Cheng, Zijing Zhou, Mingxi Yao, Yang Guo, Ze-Yan Yu, Yogambha Ramaswamy, Lining Arnold Ju, Philip W. Kuchel, Michael P. Feneley, Diane Fatkin, Charles D. Cox
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-17 (2021)
Li et al. investigates the role of N-linked glycosylation for the function of mechanosensitive ion channel Piezo1. They show that disease-linked loss of function mutations in Piezo1 that are trafficking defective lack N-linked glycosylation.
Externí odkaz:
https://doaj.org/article/838c42e3bd25417ab25bf8adfdc60922
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-18 (2021)
Abstract We present mathematical simulations of shapes of red blood cells (RBCs) and their cytoskeleton when they are subjected to linear strain. The cell surface is described by a previously reported quartic equation in three dimensional (3D) Cartes
Externí odkaz:
https://doaj.org/article/c4ea9182246c41c19c143aaea2d7f346
Publikováno v:
Magnetic Resonance, Vol 2, Pp 421-446 (2021)
We describe an approach to formulating the kinetic master equations of the time evolution of NMR signals in reacting (bio)chemical systems. Special focus is given to studies that employ signal enhancement (hyperpolarization) methods such as dissoluti
Externí odkaz:
https://doaj.org/article/78bb8c4979154b51a4376d8275ec7cfe
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract We present the first direct nuclear magnetic resonance (NMR) evidence of enhanced entry of Ca2+ ions into human erythrocytes (red blood cells; RBCs), when these cells are mechanically distorted. For this we loaded the RBCs with the fluorinat
Externí odkaz:
https://doaj.org/article/cdb8c935e89246b4977bec8744a49a67
Taipan Natriuretic Peptides Are Potent and Selective Agonists for the Natriuretic Peptide Receptor A
Autor:
Simone Vink, Kalyana Bharati Akondi, Jean Jin, Kim Poth, Allan M. Torres, Philip W. Kuchel, Sandra L. Burke, Geoffrey A. Head, Paul F. Alewood
Publikováno v:
Molecules, Vol 28, Iss 7, p 3063 (2023)
Cardiovascular ailments are a major cause of mortality where over 1.3 billion people suffer from hypertension leading to heart-disease related deaths. Snake venoms possess a broad repertoire of natriuretic peptides with therapeutic potential for trea
Externí odkaz:
https://doaj.org/article/8d087dbe4d39472f8fb2a289696eac82
Autor:
Keyun Shou, Mona Sarter, Nicolas R. de Souza, Liliana de Campo, Andrew E. Whitten, Philip W. Kuchel, Christopher J. Garvey, Andreas M. Stadler
Publikováno v:
Royal Society Open Science, Vol 7, Iss 10 (2020)
By using a combination of experimental neutron scattering techniques, it is possible to obtain a statistical perspective on red blood cell (RBC) shape in suspensions, and the inter-relationship with protein interactions and dynamics inside the confin
Externí odkaz:
https://doaj.org/article/9aee2be95bf849e4a8f5161960fd4c22
Autor:
Philip W. Kuchel, Dmitry Shishmarev
Publikováno v:
Journal of Magnetic Resonance Open, Vol 1, Iss , Pp 100001- (2019)
ABSTRACT: Dissolution dynamic nuclear polarization (dDNP) provides strikingly increased sensitivity for detecting NMR-receptive nuclei in molecules that are substrates of enzymes and membrane transport proteins. This paves the way for studying the ki
Externí odkaz:
https://doaj.org/article/fc91aa82eba7415492275b503df9e7f1