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Akademický článek

Muscle-Specific Ablation of Glucose Transporter 1 (GLUT1) Does Not Impair Basal or Overload-Stimulated Skeletal Muscle Glucose Uptake

Autor: Shawna L. McMillin, Parker L. Evans, William M. Taylor, Luke A. Weyrauch, Tyler J. Sermersheim, Steven S. Welc, Monique R. Heitmeier, Richard C. Hresko, Paul W. Hruz, Francoise Koumanov, Geoffrey D. Holman, E. Dale Abel, Carol A. Witczak

Publikováno v: Biomolecules, Vol 12, Iss 12, p 1734 (2022)

Glucose transporter 1 (GLUT1) is believed to solely mediate basal (insulin-independent) glucose uptake in skeletal muscle; yet recent work has demonstrated that mechanical overload, a model of resistance exercise training, increases muscle GLUT1 leve

Externí odkaz: https://doaj.org/article/147a73ac6c2d4bab8a2344c5e3fe0de0

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Akademický článek

Metabolic and Cardiac Adaptation to Chronic Pharmacologic Blockade of Facilitative Glucose Transport in Murine Dilated Cardiomyopathy and Myocardial Ischemia

Autor: Monique R. Heitmeier, Maria A. Payne, Carla Weinheimer, Attila Kovacs, Richard C. Hresko, Patrick Y. Jay, Paul W. Hruz

Publikováno v: Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)

Abstract GLUT transgenic and knockout mice have provided valuable insight into the role of facilitative glucose transporters (GLUTs) in cardiovascular and metabolic disease, but compensatory physiological changes can hinder interpretation of these mo

Externí odkaz: https://doaj.org/article/eeb94a2a3685407890ba31775830ba3a

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Akademický článek

MEPicides: potent antimalarial prodrugs targeting isoprenoid biosynthesis

Autor: Rachel L. Edwards, Robert C. Brothers, Xu Wang, Maxim I. Maron, Peter D. Ziniel, Patricia S. Tsang, Thomas E. Kraft, Paul W. Hruz, Kim C. Williamson, Cynthia S. Dowd, Audrey R. Odom John

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)

Abstract The emergence of Plasmodium falciparum resistant to frontline therapeutics has prompted efforts to identify and validate agents with novel mechanisms of action. MEPicides represent a new class of antimalarials that inhibit enzymes of the met

Externí odkaz: https://doaj.org/article/539d6d0aabfc46c68f5a489b64e29fac

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Akademický článek

Identification of druggable small molecule antagonists of the Plasmodium falciparum hexose transporter PfHT and assessment of ligand access to the glucose permeation pathway via FLAG-mediated protein engineering.

Autor: Monique R Heitmeier, Richard C Hresko, Rachel L Edwards, Michael J Prinsen, Ma Xenia G Ilagan, Audrey R Odom John, Paul W Hruz

Publikováno v: PLoS ONE, Vol 14, Iss 5, p e0216457 (2019)

Although the Plasmodium falciparum hexose transporter PfHT has emerged as a promising target for anti-malarial therapy, previously identified small-molecule inhibitors have lacked promising drug-like structural features necessary for development as c

Externí odkaz: https://doaj.org/article/5b482186f44d47e980b0f7cc11450eff

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Akademický článek

Exenatide improves glucose homeostasis and prolongs survival in a murine model of dilated cardiomyopathy.

Autor: Arpita Kalla Vyas, Kai-Chien Yang, Dennis Woo, Anatoly Tzekov, Attila Kovacs, Patrick Y Jay, Paul W Hruz

Publikováno v: PLoS ONE, Vol 6, Iss 2, p e17178 (2011)

There is growing awareness of secondary insulin resistance and alterations in myocardial glucose utilization in congestive heart failure. Whether therapies that directly target these changes would be beneficial is unclear. We previously demonstrated

Externí odkaz: https://doaj.org/article/78ccf4e41e83411190ae8c474fd1cb3f

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Akademický článek

HIV protease inhibitors act as competitive inhibitors of the cytoplasmic glucose binding site of GLUTs with differing affinities for GLUT1 and GLUT4.

Autor: Richard C Hresko, Paul W Hruz

Publikováno v: PLoS ONE, Vol 6, Iss 9, p e25237 (2011)

The clinical use of several first generation HIV protease inhibitors (PIs) is associated with the development of insulin resistance. Indinavir has been shown to act as a potent reversible noncompetitive inhibitor of zero-trans glucose influx via dire

Externí odkaz: https://doaj.org/article/bd4b1ea7324244afb0ae5d31247e75d3

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3-Hydroxy-3-methylglutaryl-CoA lyase: expression and isolation of the recombinant human enzyme and investigation of a mechanism for regulation of enzyme activity

Autor: J R, Roberts, C, Narasimhan, P W, Hruz, G A, Mitchell, H M, Miziorko

Publikováno v: The Journal of biological chemistry. 269(27)

cDNA encoding the mature form of human hydroxy-methylglutaryl-CoA (HMG-CoA) lyase, a mitochondrial matrix protein, has been used to prepare expression plasmids appropriate for production of this protein in Escherichia coli. Using a T7 RNA polymerase-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d49281507ce4111318bf8ead718db7f1
https://pubmed.ncbi.nlm.nih.gov/8027038

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3-Hydroxy-3-methylglutaryl coenzyme A lyase (HL). Cloning of human and chicken liver HL cDNAs and characterization of a mutation causing human HL deficiency

Autor: G A, Mitchell, M F, Robert, P W, Hruz, S, Wang, G, Fontaine, C E, Behnke, L M, Mende-Mueller, K, Schappert, C, Lee, K M, Gibson, H M, Miziorko

Publikováno v: The Journal of biological chemistry. 268(6)

3-Hydroxy-3-methylglutaryl coenzyme A lyase (HL) catalyzes the final step of ketogenesis, an important pathway of mammalian energy metabolism. HL deficiency is an autosomal recessive inborn error in man leading to episodes of hypoglycemia and coma. U

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e184414fb636e5843979f74fce17515f
https://pubmed.ncbi.nlm.nih.gov/8440722

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