Zobrazeno 1 - 10
of 20
pro vyhledávání: '"P W, Gunning"'
Autor:
Reena Kumari, Katharina Ven, Megan Chastney, Shrikant B. Kokate, Johan Peränen, Jesse Aaron, Konstantin Kogan, Leonardo Almeida-Souza, Elena Kremneva, Renaud Poincloux, Teng-Leong Chew, Peter W. Gunning, Johanna Ivaska, Pekka Lappalainen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract Focal adhesions (FAs) connect inner workings of cell to the extracellular matrix to control cell adhesion, migration and mechanosensing. Previous studies demonstrated that FAs contain three vertical layers, which connect extracellular matrix
Externí odkaz:
https://doaj.org/article/52ca205f2286428288ed7a744d2eb902
Autor:
Xiaojuan Zhao, Dominic Alibhai, Tony G. Walsh, Nathalie Tarassova, Maximilian Englert, Semra Z. Birol, Yong Li, Christopher M. Williams, Chris R. Neal, Philipp Burkard, Stephen J. Cross, Elizabeth W. Aitken, Amie K. Waller, José Ballester Beltrán, Peter W. Gunning, Edna C. Hardeman, Ejaife O. Agbani, Bernhard Nieswandt, Ingeborg Hers, Cedric Ghevaert, Alastair W. Poole
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Platelets, small hemostatic blood cells, are derived from megakaryocytes. Both bone marrow and lung are principal sites of thrombopoiesis although underlying mechanisms remain unclear. Outside the body, however, our ability to generate large
Externí odkaz:
https://doaj.org/article/b34379c46b594e3991173e9d3c71b0ac
Autor:
James Rae, Charles Ferguson, Nicholas Ariotti, Richard I Webb, Han-Hao Cheng, James L Mead, James D Riches, Dominic JB Hunter, Nick Martel, Joanne Baltos, Arthur Christopoulos, Nicole S Bryce, Maria Lastra Cagigas, Sachini Fonseka, Marcel E Sayre, Edna C Hardeman, Peter W Gunning, Yann Gambin, Thomas E Hall, Robert G Parton
Publikováno v:
eLife, Vol 10 (2021)
Genetic tags allow rapid localization of tagged proteins in cells and tissues. APEX, an ascorbate peroxidase, has proven to be one of the most versatile and robust genetic tags for ultrastructural localization by electron microscopy (EM). Here, we de
Externí odkaz:
https://doaj.org/article/de648e408e3f416f9efd1c844760a3c8
Autor:
Amr Abouelezz, Holly Stefen, Mikael Segerstråle, David Micinski, Rimante Minkeviciene, Lauri Lahti, Edna C. Hardeman, Peter W. Gunning, Casper C. Hoogenraad, Tomi Taira, Thomas Fath, Pirta Hotulainen
Publikováno v:
iScience, Vol 23, Iss 5, Pp - (2020)
Summary: The axon initial segment (AIS) is the site of action potential initiation and serves as a cargo transport filter and diffusion barrier that helps maintain neuronal polarity. The AIS actin cytoskeleton comprises actin patches and periodic sub
Externí odkaz:
https://doaj.org/article/3e57b0157379454eb6ea69f71bced384
Overexpression of Tropomyosin Isoform Tpm3.1 Does Not Alter Synaptic Function in Hippocampal Neurons
Autor:
Chanchanok Chaichim, Tamara Tomanic, Holly Stefen, Esmeralda Paric, Lucy Gamaroff, Alexandra K. Suchowerska, Peter W. Gunning, Yazi D. Ke, Thomas Fath, John Power
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 17, p 9303 (2021)
Tropomyosin (Tpm) has been regarded as the master regulator of actin dynamics. Tpms regulate the binding of the various proteins involved in restructuring actin. The actin cytoskeleton is the predominant cytoskeletal structure in dendritic spines. It
Externí odkaz:
https://doaj.org/article/f43bf5e678f54905a50e2094698b48e2
A RhoA-FRET Biosensor Mouse for Intravital Imaging in Normal Tissue Homeostasis and Disease Contexts
Autor:
Max Nobis, David Herrmann, Sean C. Warren, Shereen Kadir, Wilfred Leung, Monica Killen, Astrid Magenau, David Stevenson, Morghan C. Lucas, Nadine Reischmann, Claire Vennin, James R.W. Conway, Alice Boulghourjian, Anaiis Zaratzian, Andrew M. Law, David Gallego-Ortega, Christopher J. Ormandy, Stacey N. Walters, Shane T. Grey, Jacqueline Bailey, Tatyana Chtanova, Julian M.W. Quinn, Paul A. Baldock, Peter I. Croucher, Juliane P. Schwarz, Agata Mrowinska, Lei Zhang, Herbert Herzog, Andrius Masedunskas, Edna C. Hardeman, Peter W. Gunning, Gonzalo del Monte-Nieto, Richard P. Harvey, Michael S. Samuel, Marina Pajic, Ewan J. McGhee, Anna-Karin E. Johnsson, Owen J. Sansom, Heidi C.E. Welch, Jennifer P. Morton, Douglas Strathdee, Kurt I. Anderson, Paul Timpson
Publikováno v:
Cell Reports, Vol 21, Iss 1, Pp 274-288 (2017)
The small GTPase RhoA is involved in a variety of fundamental processes in normal tissue. Spatiotemporal control of RhoA is thought to govern mechanosensing, growth, and motility of cells, while its deregulation is associated with disease development
Externí odkaz:
https://doaj.org/article/c83a8ae4b29e4df59cdaacb8bc5a5802
Autor:
Zahra Erami, David Herrmann, Sean C. Warren, Max Nobis, Ewan J. McGhee, Morghan C. Lucas, Wilfred Leung, Nadine Reischmann, Agata Mrowinska, Juliane P. Schwarz, Shereen Kadir, James R.W. Conway, Claire Vennin, Saadia A. Karim, Andrew D. Campbell, David Gallego-Ortega, Astrid Magenau, Kendelle J. Murphy, Rachel A. Ridgway, Andrew M. Law, Stacey N. Walters, Shane T. Grey, David R. Croucher, Lei Zhang, Herbert Herzog, Edna C. Hardeman, Peter W. Gunning, Christopher J. Ormandy, T.R. Jeffry Evans, Douglas Strathdee, Owen J. Sansom, Jennifer P. Morton, Kurt I. Anderson, Paul Timpson
Publikováno v:
Cell Reports, Vol 14, Iss 1, Pp 152-167 (2016)
E-cadherin-mediated cell-cell junctions play a prominent role in maintaining the epithelial architecture. The disruption or deregulation of these adhesions in cancer can lead to the collapse of tumor epithelia that precedes invasion and subsequent me
Externí odkaz:
https://doaj.org/article/df26cad288c04a3b996446d05fb3fd9a
Autor:
Peter W Gunning, Edna C Hardeman
Publikováno v:
eLife, Vol 7 (2018)
The differences between β- and γ-actin are deeper than those between the amino acid sequences of these two proteins.
Externí odkaz:
https://doaj.org/article/2e3a72dacb4648b48c7b0d45c0c79f28
Autor:
Alexandra K. Suchowerska, Sandra Fok, Holly Stefen, Peter W. Gunning, Edna C. Hardeman, John Power, Thomas Fath
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 11 (2017)
Nerve cell connections, formed in the developing brain of mammals, undergo a well-programmed process of maturation with changes in their molecular composition over time. The major structural element at the post-synaptic specialization is the actin cy
Externí odkaz:
https://doaj.org/article/f111173399c84e5ab15eb07d2fef8de4
Autor:
Mark A Appaduray, Andrius Masedunskas, Nicole S Bryce, Christine A Lucas, Sean C Warren, Paul Timpson, Jeffrey H Stear, Peter W Gunning, Edna C Hardeman
Publikováno v:
PLoS ONE, Vol 11, Iss 12, p e0168203 (2016)
The actin cytoskeleton is a dynamic network of filaments that is involved in virtually every cellular process. Most actin filaments in metazoa exist as a co-polymer of actin and tropomyosin (Tpm) and the function of an actin filament is primarily def
Externí odkaz:
https://doaj.org/article/e58eb5c67b98417db2dbd4270007b02b