Zobrazeno 1 - 10 of 16 pro vyhledávání: '"P V Kostetskiĭ"'
1
A conformational analysis of biologically active RGD-containing cyclopentapeptides
Autor: I V Artem'ev, P V Kostetskiĭ
Publikováno v: Russian Journal of Bioorganic Chemistry. 26:262-270
The theoretical conformational analysis of the biologically active RGD-containing pentapeptide cyclo(-Arg-Gly-Asp-Phe-DVal-), an inhibitor of laminin P1 interaction with its receptor, was performed. The space of permissible torsional angles of the ba
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dd454933c10be7381c93ae4e6f9a8e38
https://doi.org/10.1007/bf02759165
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2
[The volume and structure of the chymotrypsin active site]
Autor: P V, Kostetskiĭ
Publikováno v: Biofizika. 50(6)
It was found that the chymotrypsin active site is located in the largest cleft on the enzyme surface approximated by a sphere with a radius of 20 angstroms. The active site cleft volume is about 2 nm3, as computed by the Monte-Carlo method. The size
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4df8d7147f61bcf549afc0824c69f658
https://pubmed.ncbi.nlm.nih.gov/16358776
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3
[The mobility of the side chains of His57 and other amino acid residues in the active center of chymotrypsin]
Autor: P V, Kostetskiĭ
Publikováno v: Biofizika. 49(4)
Using the "hard-sphere" atom-atom approximation with consideration of the available X-ray data, the possibility of free rotation of the side chain of His57 residue in the active center of chymotrypsin was studied. It was shown that there is a signifi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9a545ce0619fc5ff77bf2e73073e460f
https://pubmed.ncbi.nlm.nih.gov/15458241
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4
[Conformational analysis of biologically active RGD-containing cyclopentapeptides]
Autor: P V, Kostetskiĭ, I V, Artem'ev
Publikováno v: Bioorganicheskaia khimiia. 26(4)
The theoretical conformational analysis of the biologically active RGD-containing pentapeptide cyclo(-Arg-Gly-Asp-Phe-DVal-), an inhibitor of laminin P1 interaction with its receptor, was performed. The space of permissible torsional angles of the ba
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::10a284c1c529deb4031eb8d5c4d7fdca
https://pubmed.ncbi.nlm.nih.gov/10857021
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6
[Conformational states of cyclic dipeptides with lactam bond between omega-functions of lysine and aspartic or glutamic acid residues]
Autor: P V, Kostetskiĭ, S F, Arkhipova, I V, Artem'ev, I L, Rodionov, L N, Rodionova, V T, Ivanov
Publikováno v: Bioorganicheskaia khimiia. 23(7)
The conformations of H-Lys-Asp-OH and H-Glu-Lys-OH cyclic dipeptides were subjected to theoretical analysis by the method of atom-atom potentials with flexible geometry. Constants of spin-spin coupling of vicinal protons were calculated for the theor
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::24abae0cd2ceb3602d52f52864ebb5e2
https://pubmed.ncbi.nlm.nih.gov/9471972
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7
[Lysine residue as an amino acid substitute for conformational constraint of Xaa-Asp fragment of biologically active peptides using side chain lactamization]
Autor: P V, Kostetskiĭ, I V, Artem'ev
Publikováno v: Bioorganicheskaia khimiia. 23(3)
The model cyclopeptide Ac-Lys-Asp-NHMe was used to test Lys as a possible substitute for Xaa in peptide fragment Xaa-Asp whose conformational mobility would be constrained by lactamization of the Lys and Asp side chains. By means of theoretical confo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c36731a3ded5bafb0c45a66ccfea2cbf
https://pubmed.ncbi.nlm.nih.gov/9190787
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8
[Conserved and variable segments of amino acid sequences in alpha-subunits of nicotinic acetylcholine receptors and alpha-bungarotoxin-binding proteins]
Autor: P V, Kostetskiĭ, S F, Arkhipova, Iu N, Utkin, V I, Tsetlin
Publikováno v: Biokhimiia (Moscow, Russia). 59(2)
A comparative study has been carried out of homologous amino acid sequences of alpha-subunits of acetylcholine receptors (AChR) and related proteins classified into three groups: (i) alpha-bungarotoxin-binding alpha-subunits of nicotine AChR from ver
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f9e7e16143d384f062d64e1a521ffcf2
https://pubmed.ncbi.nlm.nih.gov/8155780
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9
[Uneven distribution of amino acid substitutions throughout the amino acid sequence of homologous proteins]
Autor: P V, Kostetskiĭ
Publikováno v: Biokhimiia (Moscow, Russia). 57(12)
A set of aligned homologous protein sequences is divided into two groups consisting of m and n most related sequences. The value of position variability for homologous protein sequences is defined as a number of failures to coincide in the intergroup
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d87ae077bf7b24eca0d8901118f8b9b8
https://pubmed.ncbi.nlm.nih.gov/1294256
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10
[Localization of conserved and variable segments in amino acid sequences of homologous proteins using a personal computer]
Autor: P V, Kostetskiĭ, R R, Vladimirova
Publikováno v: Molekuliarnaia biologiia. 26(4)
A set of aligned homologous protein sequences is divided into two groups consisting of the most related sequences m and k. The value of the position variability of homologous protein sequences is defined as a number of failures to coincide in the int
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0b7064837a81b0f70f6c899cbfcfcb8a
https://pubmed.ncbi.nlm.nih.gov/1435778
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