Zobrazeno 1 - 10
of 82
pro vyhledávání: '"P V, Vrzheshch"'
Publikováno v:
Russian Journal of Bioorganic Chemistry. 47:1051-1059
Modeling the flow and level of prostaglandins in open systems under the action of prostaglandin H synthase (PGHS) inhibitors (nonsteroidal anti-inflammatory drugs, NSAIDs) was carried out. These open systems included a steady PGHS input, fast inactiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dc114bb68c905c5e4b2f14924c8dc546
https://doi.org/10.1134/s1068162021050289
https://doi.org/10.1134/s1068162021050289
Autor:
P. V. Vrzheshch
Publikováno v:
Biophysics. 61:373-379
A quantitative evaluation of the accuracy of the rapid-equilibrium assumption in steady-state enzyme kinetics was obtained for a multipath arbitrary enzyme mechanism with a number of equilibrium segments. Explicit expressions for estimating the contr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7b291c74dc839862ce443a5e6a324ed4
https://doi.org/10.1134/s0006350916030210
https://doi.org/10.1134/s0006350916030210
Autor:
A. P. Berzova, P. V. Vrzheshch, I. S. Filimonov, A. V. Krivoshey, N. A. Trushkin, V. I. Barkhatov
Publikováno v:
Biochemistry. Biokhimiia. 83(2)
The kinetic mechanism of the interaction of nonsteroidal anti-inflammatory drugs (NSAIDs) with their main pharmacological target, prostaglandin H synthase (PGHS), has not yet been established. We showed that inhibition of PGHS-1 from sheep vesicular
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https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a7e965b18c3aa5fc4722dfbd6eda70e
https://pubmed.ncbi.nlm.nih.gov/29618298
https://pubmed.ncbi.nlm.nih.gov/29618298
Autor:
P. V. Vrzheshch
Publikováno v:
Biophysics. 60:205-211
Quantitative evaluation of the accuracy of the rapid equilibrium assumption in the steady-state enzyme kinetics was obtained for an arbitrary mechanism of an enzyme-catalyzed reaction. This evaluation depends only on the structure and properties of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4df4266426743b64eb65456d78e397a8
https://doi.org/10.1134/s0006350915020219
https://doi.org/10.1134/s0006350915020219
New relations for steady-state enzyme kinetics and their application to rapid equilibrium assumption
Autor:
P. V. Vrzheshch
Publikováno v:
Biophysics. 58:748-753
With the use of graph theory, new relations for steady-state enzyme kinetics are derived and strictly proved for an arbitrary mechanism of enzyme-catalyzed reaction containing a reversible segment. Using these relations, a general principle for rapid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b6dfcbb4ce55a25dca5543f8774bc020
https://doi.org/10.1134/s0006350913060213
https://doi.org/10.1134/s0006350913060213
Autor:
P. V. Vrzheshch
Publikováno v:
Biochemistry (Moscow). 75:1374-1382
Application of the quasi-equilibrium assumption for the steady-state kinetics of bisubstrate irreversible enzymat- ic reactions in the case of ordered binding of substrates (Bi-Bi ordered mechanism) is considered. The necessary and suffi- cient condi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fa91163a82efbc34415477bd5451290
https://doi.org/10.1134/s000629791011009x
https://doi.org/10.1134/s000629791011009x
Publikováno v:
Biochemistry (Moscow). 75:1368-1373
For the cyclooxygenase reaction of prostaglandin-H-synthase isolated from ram vesicular glands, dependences of the initial reaction rate, the maximal yield of the product, and the rate constant of enzyme inactivation in the course of reac- tion on ox
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91382e310605ee88f142f8875c665f92
https://doi.org/10.1134/s0006297910110088
https://doi.org/10.1134/s0006297910110088
Autor:
A. M. Saletsky, E. P. Vrzheshch, P. V. Vrzheshch, G. S. Rudanov, V. E. Zagidullin, Vladimir Z. Paschenko, D. V. Dmitrienko, A. P. Razzhivin
Publikováno v:
Moscow University Biological Sciences Bulletin. 63:109-112
For the expression in E. coli, the PCR-amplified fragment encoding mRFP1 from vector pMT-mRFP1 (Fungal Genetic Stock Center) was placed in the pQE-60 vector. Chemically competent E. coli ER1821 were transformed and grown overnight at 37°C. The prote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aaf157539713f70937b4c22a4b3833d5
https://doi.org/10.3103/s0096392508030036
https://doi.org/10.3103/s0096392508030036
Autor:
I. S. Filimonov, P. V. Vrzheshch
Publikováno v:
Biochemistry (Moscow). 72:944-953
Prostaglandin-H-synthase is a bifunctional enzyme catalyzing conversion of arachidonic acid into prostaglandin H2 as a result of cyclooxygenase and peroxidase reactions. The dependence of the rate of the cyclooxygenase reaction on oxygen concentratio
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https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01c6eb1223b157ac005d62b27fa8542f
https://doi.org/10.1134/s0006297907090040
https://doi.org/10.1134/s0006297907090040
Autor:
P. V. Vrzheshch
Publikováno v:
Biochemistry (Moscow). 72:936-943
A steady-state approximation of the generalized two-dimensional model of a bifunctional enzyme catalyzing independent proceeding of two one-pathway reactions is considered in a case of mutual influence of the active sites. Coexistence of fast and slo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17b73f9e5afbfcd4dfe526d92d1b98a7
https://doi.org/10.1134/s0006297907090039
https://doi.org/10.1134/s0006297907090039