MicroRNA profile of extracellular vesicles released by Müller glial cells

Autor: William D. B. Lamb, Karen Eastlake, Joshua Luis, Najam A. Sharif, Peng T. Khaw, G. Astrid Limb

Publikováno v: Frontiers in Cellular Neuroscience, Vol 17 (2024)

IntroductionAs with any other radial glia in the central nervous system, Müller glia derive from the same neuroepithelial precursors, perform similar functions, and exhibit neurogenic properties as radial glia in the brain. Müller glial cells retai

Externí odkaz: https://doaj.org/article/9ecf20fce74d49e7adbb0f170f740a47

Genome-wide meta-analysis identifies 127 open-angle glaucoma loci with consistent effect across ancestries

Autor: Puya Gharahkhani, Eric Jorgenson, Pirro Hysi, Anthony P. Khawaja, Sarah Pendergrass, Xikun Han, Jue Sheng Ong, Alex W. Hewitt, Ayellet V. Segrè, John M. Rouhana, Andrew R. Hamel, Robert P. Igo, Helene Choquet, Ayub Qassim, Navya S. Josyula, Jessica N. Cooke Bailey, Pieter W. M. Bonnemaijer, Adriana Iglesias, Owen M. Siggs, Terri L. Young, Veronique Vitart, Alberta A. H. J. Thiadens, Juha Karjalainen, Steffen Uebe, Ronald B. Melles, K. Saidas Nair, Robert Luben, Mark Simcoe, Nishani Amersinghe, Angela J. Cree, Rene Hohn, Alicia Poplawski, Li Jia Chen, Shi-Song Rong, Tin Aung, Eranga Nishanthie Vithana, NEIGHBORHOOD consortium, ANZRAG consortium, Biobank Japan project, FinnGen study, UK Biobank Eye and Vision Consortium, GIGA study group, and Me Research Team, Gen Tamiya, Yukihiro Shiga, Masayuki Yamamoto, Toru Nakazawa, Hannah Currant, Ewan Birney, Xin Wang, Adam Auton, Michelle K. Lupton, Nicholas G. Martin, Adeyinka Ashaye, Olusola Olawoye, Susan E. Williams, Stephen Akafo, Michele Ramsay, Kazuki Hashimoto, Yoichiro Kamatani, Masato Akiyama, Yukihide Momozawa, Paul J. Foster, Peng T. Khaw, James E. Morgan, Nicholas G. Strouthidis, Peter Kraft, Jae H. Kang, Chi Pui Pang, Francesca Pasutto, Paul Mitchell, Andrew J. Lotery, Aarno Palotie, Cornelia van Duijn, Jonathan L. Haines, Chris Hammond, Louis R. Pasquale, Caroline C. W. Klaver, Michael Hauser, Chiea Chuen Khor, David A. Mackey, Michiaki Kubo, Ching-Yu Cheng, Jamie E. Craig, Stuart MacGregor, Janey L. Wiggs

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)

Primary open-angle glaucoma (POAG) is highly heritable, yet not well understood from a genetic perspective. Here, the authors perform a meta-analysis of genome-wide association studies in 34,179 POAG cases, identifying 44 previously unreported risk l

Externí odkaz: https://doaj.org/article/ea46188f0f2c4f0cae58f959caf971a2

Grand Challenges in global eye health: a global prioritisation process using Delphi method

Autor: Jacqueline Ramke, PhD, Jennifer R Evans, PhD, Esmael Habtamu, PhD, Nyawira Mwangi, PhD, Juan Carlos Silva, MD, Bonnielin K Swenor, PhD, Nathan Congdon, ProfMD, Hannah B Faal, ProfFRCOphth, Allen Foster, ProfFRCOphth, David S Friedman, ProfPhD, Stephen Gichuhi, PhD, Jost B Jonas, ProfPhD, Peng T Khaw, ProfPhD, Fatima Kyari, PhD, Gudlavalleti V S Murthy, ProfMD, Ningli Wang, ProfPhD, Tien Y Wong, ProfMD, Richard Wormald, MSc, Mayinuer Yusufu, MTI, Hugh Taylor, FRANZCO, Serge Resnikoff, ProfPhD, Sheila K West, ProfPhD, Matthew J Burton, ProfPhD, Ada Aghaji, Adeyemi T Adewole, Adrienne Csutak, Ahmad Shah Salam, Ala Paduca, Alain M Bron, Alastair K Denniston, Alberto Lazo Legua, Aldiana Halim, Alemayehu Woldeyes Tefera, Alice Mwangi, Alicia J Jenkins, Amanda Davis, Amel Meddeb-Ouertani, Amina H Wali, Ana G Palis, Ana Bastos de Carvalho, Anagha Joshi, Andreas J Kreis, Andreas Mueller, Andrew Bastawrous, Andrew Cooper, Andrew F Smith, Andrzej Grzybowski, Anitha Arvind, Anne M Karanu, Anne O Orlina, Anthea Burnett, Aryati Yashadhana, Asela P Abeydeera, Aselia Abdurakhmanova, Ashik Mohamed, Ashish Bacchav, Ashlie Bernhisel, Aubrey Walton Webson, Augusto Azuara-Blanco, Ava Hossain, Bayazit Ilhan, Bella Assumpta Lucienne, Benoit Tousignant, Bindiganavale R Shamanna, Boateng Wiafe, Brigitte Mueller, Cagatay Caglar, Caleb Mpyet, Carl H Abraham, Carol Y Cheung, Cassandra L Thiel, Catherine L Jan, Chike Emedike, Chimgee Chuluunkhuu, Chinomso Chinyere, Christin Henein, Clare E Gilbert, Covadonga Bascaran, Cristina Elena Nitulescu, Daksha Patel, Damodar Bachani, Daniel Kiage, Daniel Etya'ale, David Dahdal, Dawn Woo Lawson, Denise Godin, Dennis G Nkanga, Dennis M Ondeyo, Donna O'Brien, Dorothy M Mutie, Ebtisam S K Alalawi, Eduardo Mayorga, Effendy Bin Hashim, Elham Ashrafi, Elizabeth Andrew Kishiki, Elizabeth Kurian, Fabrizio D'Esposito, Faith Masila, Fernando Yaacov Pena, Fortunat Büsch, Fotis Topouzis, Francesco Bandello, Funmilayo J Oyediji, Gabriele Thumann, Gamal Ezz Elarab, Gatera Fiston Kitema, Gerhard Schlenther, Gertrude Oforiwa Fefoame, Gillian M Cochrane, Guna Laganovska, Haroon R Awan, Harris M Ansari, Heiko Philippin, Helen Burn, Helen Dimaras, Helena P Filipe, Henrietta I Monye, Himal Kandel, Hoby Lalaina Randrianarisoa, Iain Jones, Ian E Murdoch, Ido Didi Fabian, Imran A Khan, Indra P Sharma, Islam Elbeih, Islay Mactaggart, J Carlos Pastor, Jan E E Keunen, Jane A Ohuma, Jason Pithuwa Nirwoth, Jaouad Hammou, Jayme R Vianna, Jean-eudes Biao, Jennifer M Burr, Jeremy D Keenan, Jess Blijkers, Joanna M Black, Joao Barbosa Breda, Joao M Furtado, John C Buchan, John G Lawrenson, John H Kempen, Joshua R Ehrlich, Judith Stern, Justine H Zhang, Kadircan H Keskinbora, Karin M Knoll, Karl Blanchet, Katrina L Schmid, Koichi Ono, Kolawole Ogundimu, Komi Balo, Kussome Paulin Somda, Kwame Yeboah, Kwesi N Amissah-Arthur, Leone Nasehi, Lene Øverland, Lingam Vijaya, Lisa Keay, Lisa M Hamm, Lizette Mowatt, Lloyd C M Harrison-Williams, Lucia Silva, Luigi Bilotto, Manfred Mörchen, Mansur Rabiu, Marcia Zondervan, Margarida Chagunda, Maria Teresa Sandinha, Mariano Yee Melgar, Marisela Salas Vargas, Mark D Daniell, Marzieh Katibeh, Matt Broom, Megan E Collins, Mehmet Numan Alp, Michael A Kwarteng, Michael Belkin, Michael Gichangi, Michelle Sylvanowicz, Min Wu, Miriam R Cano, Mohammad Shalaby, Mona Duggal, Moncef Khairallah, Muhammed Batur, Mukharram M Bikbov, Muralidhar Ramappa, Nagaraju Pamarathi, Naira Khachatryan, Nasiru Muhammad, Neil Kennedy, Neil Murray, Nicholas A V Beare, Nick Astbury, Nicole A Carnt, Nigel A St Rose, Nigel H Barker, Niranjan K Pehere, Nkechinyere J Uche, Noemi Lois, Oluwaseun O Awe, Oscar J Mujica, Oteri E Okolo, Padmaja Kumari Rani, Paisan Ruamviboonsuk, Papa Amadou Ndiaye, Parami Dhakhwa, Pavel Rozsival, Pearl K Mbulawa, Pearse A Keane, Pete R Jones, Peter Holland, Phanindra Babu Nukella, Philip I Burgess, Pinar Aydin O'Dwyer, Prabhath Piyasena, Pradeep Bastola, Priya Morjaria, Qais Nasimee, Raizza A T Rambacal, Rajdeep Das, Rajiv B Khandekar, Rajvardhan Azad, Ramona Bashshur, Raúl A R C Sousa, Rebecca Oenga, Reeta Gurung, Robert Geneau, Robert J Jacobs, Robert P Finger, Robyn H Guymer, Rodica Sevciuc, Rohit C Khanna, Ronnie George, Ronnie Graham, Ryo Kawasaki, S May Ho, Sailesh Kumar Mishra, Sandeep Buttan, Sandra S Block, Sandra Talero, Sangchul Yoon, Sanil Joseph, Sare Safi, Sarity Dodson, Sergio R Munoz, Seydou Bakayoko, Seyed Farzad Mohammadi, Shabir Ahmad Muez, Shahina Pardhan, Shelley Hopkins, Shwu-Jiuan Sheu, Sidi Mohamed Coulibaly, Silvana A Schellini, Simon Arunga, Simon R Bush, Sobha Sivaprasad, Solange R Salomao, Srinivas Marmamula, Stella N Onwubiko, Stuti L Misra, Subeesh Kuyyadiyil, Sucheta Kulkarni, Sudarshan khanal, Sumrana Yasmin, Suzana Nikolic Pavljasevic, Suzanne S Gilbert, Tasanee Braithwaite, Tatiana Ghidirimschi, Thulasiraj Ravilla, Timothy R Fricke, Tiziana Cogliati, Tsehaynesh Kassa, Tunde Peto, Ute Dibb, Van C Lansingh, Victor H Hu, Victoria M Sheffield, Wanjiku Mathenge, William H Dean, Winifred Nolan, Yoshimune Hiratsuka, Yousaf Jamal Mahsood, Yuddha Sapkota

Publikováno v: The Lancet. Healthy Longevity, Vol 3, Iss 1, Pp e31-e41 (2022)

Summary: Background: We undertook a Grand Challenges in Global Eye Health prioritisation exercise to identify the key issues that must be addressed to improve eye health in the context of an ageing population, to eliminate persistent inequities in he

Externí odkaz: https://doaj.org/article/2b065cfdcd8540b7951cd649d9f9682e

Visual function rather than visual acuity – Authors' reply

Autor: Fatima Kyari, Rupert R A Bourne, Peng T Khaw, David S Friedman, Nathan Congdon, Jacqueline Ramke, Matthew J Burton

Publikováno v: The Lancet Global Health, Vol 9, Iss 7, Pp e914- (2021)

Externí odkaz: https://doaj.org/article/3c56e308b44946f6966c40bea4744c8e

Genetic variation affects morphological retinal phenotypes extracted from UK Biobank optical coherence tomography images.

Autor: Hannah Currant, Pirro Hysi, Tomas W Fitzgerald, Puya Gharahkhani, Pieter W M Bonnemaijer, Anne Senabouth, Alex W Hewitt, UK Biobank Eye and Vision Consortium, International Glaucoma Genetics Consortium, Denize Atan, Tin Aung, Jason Charng, Hélène Choquet, Jamie Craig, Peng T Khaw, Caroline C W Klaver, Michiaki Kubo, Jue-Sheng Ong, Louis R Pasquale, Charles A Reisman, Maciej Daniszewski, Joseph E Powell, Alice Pébay, Mark J Simcoe, Alberta A H J Thiadens, Cornelia M van Duijn, Seyhan Yazar, Eric Jorgenson, Stuart MacGregor, Chris J Hammond, David A Mackey, Janey L Wiggs, Paul J Foster, Praveen J Patel, Ewan Birney, Anthony P Khawaja

Publikováno v: PLoS Genetics, Vol 17, Iss 5, p e1009497 (2021)

Optical Coherence Tomography (OCT) enables non-invasive imaging of the retina and is used to diagnose and manage ophthalmic diseases including glaucoma. We present the first large-scale genome-wide association study of inner retinal morphology using

Externí odkaz: https://doaj.org/article/4fbf3860d58c43b3bbd68818f972b31d