Phytoestrogen-mediated inhibition of proliferation of the human T47D breast cancer cells depends on the ERα/ERβ ratio

Autor: P. T. Van Der Saag, D. Ratman, Albertinka J. Murk, Jan-Åke Gustafsson, J.J.M. Vervoort, A. M. Sotoca, Ivonne M.C.M. Rietjens, Anders Ström

Publikováno v: Journal of Steroid Biochemistry and Molecular Biology, 112(4-5), 171-178
Journal of Steroid Biochemistry and Molecular Biology 112 (2008) 4-5

This study investigates the importance of the intracellular ratio of the two estrogen receptors ERalpha and ERbeta for the ultimate potential of the phytoestrogens genistein and quercetin to stimulate or inhibit cancer cell proliferation. This is of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc3a8171239f43dae8441024e96bd591
https://doi.org/10.1016/j.jsbmb.2008.10.002

Phytanoyl-CoA hydroxylase activity is induced by phytanic acid

Autor: R. J. A. Wanders, B. van der Burg, Gerbert A. Jansen, Bwee Tien Poll-The, Anna W.M. Zomer, P. T. Van Der Saag, Nanda M. Verhoeven, Cornelis Jakobs

Publikováno v: European Journal of Biochemistry. 267:4063-4067

Phytanic acid (3,7,11,15-tetramethylhexadecanoic acid) is a branched-chain fatty acid present in various dietary products such as milk, cheese and fish. In patients with Refsum disease, accumulation of phytanic acid occurs due to a deficiency of phyt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e766c930c6cdfc521d58e16f7691cd06
https://doi.org/10.1046/j.1432-1327.2000.01451.x

A novel in bioassay for (xeno-)estrogens using transgenic zebrafish

Autor: A. Brouwer, B. van der Burg, Albertinka J. Murk, J.L.M. Broekhof, Juliette Legler, D. Zivkovic, P. Wester, A.D. Vethaak, P.H. Lanser, P. T. Van Der Saag

Publikováno v: Legler, J, Broekhof, J L M, Brouwer, A, Lanser, P H, Murk, A J, van der Saag, P T, Vethaak, A D, Wester, P, Zivkovic, D & van der Burg, B 2000, ' A novel in bioassay for (xeno-)estrogens using transgenic zebrafish ', Environmental Science and Technology, vol. 34, no. 20, pp. 4439-4444 . https://doi.org/10.1021/es0000605
Environmental Science and Technology, 34, 4439-4444
Environmental Science and Technology, 34(20), 4439-4444. American Chemical Society
Environmental Science and Technology 34 (2000)

Adverse trends in the reproductive health of male fish, including testis abnormalities and intersex gonads, have been increasingly reported over recent years. These effects have been associated with the exposure of fish to natural, synthetic, and xen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8eb29d8dc303035226811bc96cb2176d
https://hdl.handle.net/1871/31931

Differential Expression Pattern of Retinoid X Receptors in Adult Murine Testicular Cells Implies Varying Roles for these Receptors in Spermatogenesis1

Autor: Axel P. N. Themmen, Dirk G. de Rooij, Jos W. Hoogerbrugge, I. C. Gaemers, P. T. Van Der Saag, A. M. M. Van Pelt

Publikováno v: Biology of Reproduction. 58:1351-1356

Retinoids have previously been shown to be crucial for normal spermatogenesis. The role of retinoic acid receptors has been studied, but relatively little is known about the function of retinoid X receptors (RXRs). To gain more insight in the functio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::879f93e57fc2a5b63f9914ea53b9bb47
https://doi.org/10.1095/biolreprod58.6.1351

All-trans-4-oxo-retinoic acid: a potent inducer of in vivo proliferation of growth-arrested A spermatogonia in the vitamin A-deficient mouse testis

Autor: A. M. M. Van Pelt, Dirk G. de Rooij, I. C. Gaemers, P. T. Van Der Saag

Publikováno v: Endocrinology. 137:479-485

Vitamin A deficiency leads to an arrest of spermatogenesis and a loss of advanced germ cells in male mice. In the present study, the effects of several retinoids and carotenoids on these mouse testis were investigated. First, the proliferative activi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd453aeb9f842833c3bf82d5cbde4cb8
https://doi.org/10.1210/endo.137.2.8593792