Pristanic acid and phytanic acid: naturally occurring ligands for the nuclear receptor peroxisome proliferator-activated receptor α

Autor: Anna W.M. Zomer, Bart van der Burg, Gerbert A. Jansen, Ronald J.A. Wanders, Bwee Tien Poll-The, Paul T. van der Saag

Publikováno v: Journal of Lipid Research, Vol 41, Iss 11, Pp 1801-1807 (2000)

Phytanic acid and pristanic acid are branched-chain fatty acids, present at micromolar concentrations in the plasma of healthy individuals. Here we show that both phytanic acid and pristanic acid activate the peroxisome proliferator-activated recepto

Externí odkaz: https://doaj.org/article/43d5c092d7394de4b9d9030cd5ed9c7c

A novel specific bioassay for the determination of glucocorticoid bioavailability in human serum

Autor: C.E. van den Brink, S. C. van Buul-Offers, B. van der Burg, Brenda I. Hendriks-Stegeman, P. T. Van Der Saag, Maarten Jansen, Harry Vermeer

Publikováno v: Clinical Endocrinology. 59:49-55

Summary objective Some patients develop side-effects even on relatively low doses of topically administered glucocorticoids (GCs), while others appear to be less sensitive to GCs. We have developed and validated a bioassay which can measure glucocort

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6bf5646f573816680207b390dfdd8d1d
https://doi.org/10.1046/j.1365-2265.2003.01793.x

Phytanoyl-CoA hydroxylase activity is induced by phytanic acid

Autor: R. J. A. Wanders, B. van der Burg, Gerbert A. Jansen, Bwee Tien Poll-The, Anna W.M. Zomer, P. T. Van Der Saag, Nanda M. Verhoeven, Cornelis Jakobs

Publikováno v: European Journal of Biochemistry. 267:4063-4067

Phytanic acid (3,7,11,15-tetramethylhexadecanoic acid) is a branched-chain fatty acid present in various dietary products such as milk, cheese and fish. In patients with Refsum disease, accumulation of phytanic acid occurs due to a deficiency of phyt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e766c930c6cdfc521d58e16f7691cd06
https://doi.org/10.1046/j.1432-1327.2000.01451.x

A novel in bioassay for (xeno-)estrogens using transgenic zebrafish

Autor: A. Brouwer, B. van der Burg, Albertinka J. Murk, J.L.M. Broekhof, Juliette Legler, D. Zivkovic, P. Wester, A.D. Vethaak, P.H. Lanser, P. T. Van Der Saag

Publikováno v: Legler, J, Broekhof, J L M, Brouwer, A, Lanser, P H, Murk, A J, van der Saag, P T, Vethaak, A D, Wester, P, Zivkovic, D & van der Burg, B 2000, ' A novel in bioassay for (xeno-)estrogens using transgenic zebrafish ', Environmental Science and Technology, vol. 34, no. 20, pp. 4439-4444 . https://doi.org/10.1021/es0000605
Environmental Science and Technology, 34, 4439-4444
Environmental Science and Technology, 34(20), 4439-4444. American Chemical Society
Environmental Science and Technology 34 (2000)

Adverse trends in the reproductive health of male fish, including testis abnormalities and intersex gonads, have been increasingly reported over recent years. These effects have been associated with the exposure of fish to natural, synthetic, and xen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8eb29d8dc303035226811bc96cb2176d
https://hdl.handle.net/1871/31931

Differential Expression Pattern of Retinoid X Receptors in Adult Murine Testicular Cells Implies Varying Roles for these Receptors in Spermatogenesis1

Autor: Axel P. N. Themmen, Dirk G. de Rooij, Jos W. Hoogerbrugge, I. C. Gaemers, P. T. Van Der Saag, A. M. M. Van Pelt

Publikováno v: Biology of Reproduction. 58:1351-1356

Retinoids have previously been shown to be crucial for normal spermatogenesis. The role of retinoic acid receptors has been studied, but relatively little is known about the function of retinoid X receptors (RXRs). To gain more insight in the functio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::879f93e57fc2a5b63f9914ea53b9bb47
https://doi.org/10.1095/biolreprod58.6.1351