Zobrazeno 1 - 10
of 47
pro vyhledávání: '"P T, Männistö"'
Publikováno v:
Neurology and Therapy, Vol 13, Iss 4, Pp 1039-1054 (2024)
Abstract In the 1980s, Orion Pharma, then a mid-ranking Nordic area pharmaceutical company, established a drug development programme on the inhibition of catechol O-methyltransferase (COMT). This enzyme, which plays an important role in the inactivat
Externí odkaz:
https://doaj.org/article/ab03be095a6f4a37aad0b8a4273760c0
Autor:
Ville T. Männistö, Dorota Kaminska, Sylke Haal, Juho Asteljoki, Panu K. Luukkonen, Pirjo Käkelä, Federica Tavaglione, Michel van Weeghel, Mikko Neuvonen, Mikko Niemi, Stefano Romeo, Max Nieuwdorp, Jussi Pihlajamäki, Albert K. Groen
Publikováno v:
Gastro Hep Advances, Vol 3, Iss 5, Pp 594-601 (2024)
Background and Aims: Gallstone disease (GSD) associates with significant morbidity and mortality. Decreased secretion of bile acids has been suggested as a driving factor for GSD. Recently, we linked the protein phosphatase 1 regulatory subunit 3 bet
Externí odkaz:
https://doaj.org/article/7c50f06b369c41d088bab1ac22b8f9fd
Autor:
Ville T. Männistö, Marko Simonen, Pasi Soininen, Mika Tiainen, Antti J. Kangas, Dorota Kaminska, Sari Venesmaa, Pirjo Käkelä, Vesa Kärjä, Helena Gylling, Mika Ala-Korpela, Jussi Pihlajamäki
Publikováno v:
Journal of Lipid Research, Vol 55, Iss 12, Pp 2676-2684 (2014)
Nonalcoholic steatohepatitis (NASH) is associated with increased synthesis of triglycerides and cholesterol coupled with increased VLDL synthesis in the liver. In addition, increased cholesterol content in the liver associates with NASH. Here we stud
Externí odkaz:
https://doaj.org/article/6ce3836cee9240fdb6fdf90c91796c48
Autor:
Mari H. Savolainen, Christopher T. Richie, Brandon K. Harvey, Pekka T. Männistö, Kathleen A. Maguire-Zeiss, Timo T. Myöhänen
Publikováno v:
Neurobiology of Disease, Vol 68, Iss , Pp 1-15 (2014)
The misfolding and aggregation of α-synuclein (aSyn) eventually lead to an accumulation of toxic forms that disturb normal neuronal function and result in cell death. aSyn rich inclusions are seen in Parkinson's disease, dementia with Lewy bodies an
Externí odkaz:
https://doaj.org/article/c7bcb981635d436dbabcfad7192b26e0
Autor:
Leonid Yavich, Mari Oksman, Heikki Tanila, Petri Kerokoski, Mikko Hiltunen, Thomas van Groen, Jukka Puoliväli, Pekka T. Männistö, Arturo García-Horsman, Ewen MacDonald, Konrad Beyreuther, Tobias Hartmann, Pekka Jäkälä
Publikováno v:
Neurobiology of Disease, Vol 20, Iss 2, Pp 303-313 (2005)
We have generated a transgenic mouse line overexpressing mutated human A30P α-synuclein under the control of the prion-related protein promoter. Immunohistology revealed mutated human A30P α-synuclein protein in numerous brain areas, but no gross m
Externí odkaz:
https://doaj.org/article/cfe6ff5d05a7497399ad277a7d3f402a
Autor:
Nadia Schendzielorz, Juha-Pekka Oinas, Timo T Myöhänen, Ilkka Reenilä, Atso Raasmaja, Pekka T Männistö
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e61392 (2013)
The occurrence of catechol-O-methyltransferase (COMT) in presynaptic neurons remains controversial. This study utilized dopaminergic and noradrenergic toxins to assess the presence of COMT in the presynaptic neurons originating from the substantia ni
Externí odkaz:
https://doaj.org/article/d46a53daed10414a835828b620908505
Autor:
T T, Myöhänen, J, Tenorio-Laranga, B, Jokinen, R, Vázquez-Sánchez, M J, Moreno-Baylach, J A, García-Horsman, P T, Männistö
Publikováno v:
British journal of pharmacology. 163(8)
BACKGROUND AND PURPOSE A serine protease, prolyl oligopeptidase (POP) has been reported to be involved in the release of the pro-angiogenic tetrapeptide acetyl-N-Ser-Asp-Lys-Pro (Ac-SDKP) from its precursor, 43-mer thymosin β4 (Tβ4). Recently, it w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::dbf5544e21153c473c9d4c5d7e1e336b
https://pubmed.ncbi.nlm.nih.gov/21133893
https://pubmed.ncbi.nlm.nih.gov/21133893
Publikováno v:
British journal of pharmacology. 161(7)
Catechol-O-methyltransferase (COMT) inhibitors are used in Parkinson's disease in which pain is an important symptom. COMT polymorphisms modulate pain and opioid analgesia in humans. In rats, COMT inhibitors have been shown to be pro-nociceptive in a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cd1bea92abc1439a004a69f45145b0ca
https://pubmed.ncbi.nlm.nih.gov/20726980
https://pubmed.ncbi.nlm.nih.gov/20726980
Autor:
M, Käenmäki, A, Tammimäki, J A, Garcia-Horsman, T, Myöhänen, N, Schendzielorz, M, Karayiorgou, J A, Gogos, P T, Männistö
Publikováno v:
British journal of pharmacology. 158(8)
Catechol-O-methyltransferase (COMT) metabolizes compounds containing catechol structures and has two forms: soluble (S-COMT) and membrane-bound (MB-COMT). Here we report the generation of a mouse line that expresses MB-COMT but not S-COMT. We compare
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ccb72273ec93faa6b5b0e6ce8ca16b2e
https://pubmed.ncbi.nlm.nih.gov/19930170
https://pubmed.ncbi.nlm.nih.gov/19930170
Autor:
P T, Männistö, S, Kaakkola
Publikováno v:
Pharmacological reviews. 51(4)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4d66305a7aa31da4112d622ebf4a7b7c
https://pubmed.ncbi.nlm.nih.gov/10581325
https://pubmed.ncbi.nlm.nih.gov/10581325