Zobrazeno 1 - 10
of 19
pro vyhledávání: '"P Shannon, Pendergrast"'
Publikováno v:
Journal of Circulating Biomarkers, Vol 6 (2017)
The discovery of urinary extracellular biomarkers has been impeded by the lack of efficient methods for the isolation of extracellular vesicles (EVs: exosomes and microvesicles) and extracellular nucleic acid (RNA and DNA) from urine. Ultracentrifuga
Externí odkaz:
https://doaj.org/article/670a88cd8293492ba7e6a50125b5bcd9
Autor:
Jessica Neil, Caitlin Vestal Tibbetts, Kellie Marie Demock, Susan H. Smith, Christine Patricia Donahue, Jon D. Lenn, Javier Cote-Sierra, P. Shannon Pendergrast, Jason R. Killough, Adrian C. Williams, Marc B. Brown, Jean-Philippe Therrien, David Rubenstein
Publikováno v:
The Journal of investigative dermatology. 138(2)
It is generally recognized that only relatively small molecular weight (typically∼ 500 Da) drugs can effectively permeate through intact stratum corneum. Here, we challenge this orthodoxy using a 62-nucleotide (molecular weight = 20,395 Da) RNA-bas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::437fa4840700bc645675651ea77dc7e5
https://pubmed.ncbi.nlm.nih.gov/28942363
https://pubmed.ncbi.nlm.nih.gov/28942363
Autor:
P. Shannon Pendergrast, Tom Volpe
Publikováno v:
Frontiers in Biology. 8:468-474
MicroRNAs (miRNAs) are important post-transcriptional regulators of gene expression. For over a decade the deluge of research describing the biogenesis and activity of miRNAs has lead researchers to postulate rules to help make sense of the enormous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::439883ff15dd4972a75e794d07e2e445
https://doi.org/10.1007/s11515-013-1273-z
https://doi.org/10.1007/s11515-013-1273-z
Publikováno v:
Molecular Biology of the Cell. 13:915-929
FBI-1 is a cellular POZ-domain–containing protein that binds to the HIV-1 LTR and associates with the HIV-1 transactivator protein Tat. Here we show that elevated levels of FBI-1 specifically stimulate Tat activity and that this effect is dependent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05ae867c01b0e76d626c09cd6693a553
https://doi.org/10.1091/mbc.01-08-0383
https://doi.org/10.1091/mbc.01-08-0383
Publikováno v:
Journal of Circulating Biomarkers, Vol 6 (2017)
Journal of Circulating Biomarkers
Journal of Circulating Biomarkers
The discovery of urinary extracellular biomarkers has been impeded by the lack of efficient methods for the isolation of extracellular vesicles (EVs: exosomes and microvesicles) and extracellular nucleic acid (RNA and DNA) from urine. Ultracentrifuga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c318e22195ccde9a4a65e8d93c07f8f
https://doi.org/10.1177/1849454417712666
https://doi.org/10.1177/1849454417712666
A Positioned Nucleosome on the Human U6 Promoter Allows Recruitment of SNAPc by the Oct-1 POU Domain
Publikováno v:
Molecular Cell. 7:539-549
The human snRNA promoters contain a proximal sequence element (PSE) required for basal transcription and a distal sequence element (DSE) required for activated transcription. The PSE recruits the multisubunit factor SNAPc, whereas the DSE recruits Oc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cb8ef4bcaab8de3385e7ad16c9626a6
https://doi.org/10.1016/s1097-2765(01)00201-5
https://doi.org/10.1016/s1097-2765(01)00201-5
Autor:
Kathleen E. McGinness, P. Shannon Pendergrast, Robert G. Schaub, Xianbin Tian, Bernd Jilma, Yahye Merhi, Daniel Duerschmied, Jolanta M. Siller-Matula, Jean-François Tanguay, Jou-Ku Chung, Denisa D. Wagner
Publikováno v:
Arteriosclerosis, thrombosis, and vascular biology. 32(4)
Objective— We investigated the stability, pharmacokinetic, and pharmacodynamic profile of the 2 nd generation anti-von Willeband factor aptamer ARC15105. Methods and Results— Platelet plug formation was measured by collagen/adenosine diphosphate-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12d2527cf17ab88a5342df4808de6233
https://pubmed.ncbi.nlm.nih.gov/22282355
https://pubmed.ncbi.nlm.nih.gov/22282355
Publikováno v:
Biochemistry. 31:10664-10670
We have developed a simple procedure to incorporate an EDTA-metal complex at a rationally selected site within a full-length protein. Our procedure has two steps: In step 1, we use site-directed mutagenesis to introduce a unique solvent-accessible cy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec24826a6407360018962202cfb9676a
https://doi.org/10.1021/bi00159a004
https://doi.org/10.1021/bi00159a004
Autor:
Paula Burmeister, Charles Wilson, Chunhua Wang, Scott D. Lewis, Thomas Green Mccauley, Markus Kurz, Anthony D. Keefe, P. Shannon Pendergrast, Jason R. Killough, Alicia Ferguson, Sharon T. Cload, Lillian R. Horwitz, Kristin Thompson, John L. Diener
Publikováno v:
Oligonucleotides. 16(4)
Aptamers are short oligonucleotides that fold into well-defined three-dimensional architectures thereby enabling specific binding to molecular targets such as proteins. To be successful as a novel therapeutic modality, it is important for aptamers to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eca5773d3338e044b4b15cea62d63d7d
https://pubmed.ncbi.nlm.nih.gov/17155909
https://pubmed.ncbi.nlm.nih.gov/17155909
Autor:
David Epstein, P. Shannon Pendergrast
Publikováno v:
The Aptamer Handbook: Functional Oligonucleotides and Their Applications
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2bf8f45bbdbf3932489508a4bd3be247
https://doi.org/10.1002/3527608192.ch11
https://doi.org/10.1002/3527608192.ch11
