Zobrazeno 1 - 10
of 12
pro vyhledávání: '"P S Tarpey"'
Autor:
Matthew W. Fittall, William Mifsud, Nischalan Pillay, Hongtao Ye, Anna-Christina Strobl, Annelien Verfaillie, Jonas Demeulemeester, Lei Zhang, Fitim Berisha, Maxime Tarabichi, Matthew D. Young, Elena Miranda, Patrick S. Tarpey, Roberto Tirabosco, Fernanda Amary, Agamemnon E. Grigoriadis, Michael R. Stratton, Peter Van Loo, Cristina R. Antonescu, Peter J. Campbell, Adrienne M. Flanagan, Sam Behjati
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-6 (2018)
FOS has been linked to bone tumour pathogenesis, and viral homologue v-fos causes osteosarcoma in mice. Here, the authors report rearrangement of FOS and its paralogue FOSB in osteoblastoma and osteoid osteoma, revealing human bone tumours that are d
Externí odkaz:
https://doaj.org/article/e874f5cac91c4dfcb8f739743873d777
Autor:
Patrick S. Tarpey, Sam Behjati, Matthew D. Young, Inigo Martincorena, Ludmil B. Alexandrov, Sarah J. Farndon, Charlotte Guzzo, Claire Hardy, Calli Latimer, Adam P. Butler, Jon W. Teague, Adam Shlien, P. Andrew Futreal, Sohrab Shah, Ali Bashashati, Farzad Jamshidi, Torsten O. Nielsen, David Huntsman, Daniel Baumhoer, Sebastian Brandner, Jay Wunder, Brendan Dickson, Patricia Cogswell, Josh Sommer, Joanna J. Phillips, M. Fernanda Amary, Roberto Tirabosco, Nischalan Pillay, Stephen Yip, Michael R. Stratton, Adrienne M. Flanagan, Peter J. Campbell
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-6 (2017)
Chordoma is a rare often incurable malignant bone tumour. Here, the authors investigate driver mutations of sporadic chordoma in 104 cases, revealing duplications in notochordal transcription factor brachyury (T), PI3K signalling mutations, and mutat
Externí odkaz:
https://doaj.org/article/208559b87d8a4491810952fc9347c3ba
Autor:
Sam Behjati, Patrick S. Tarpey, Kerstin Haase, Hongtao Ye, Matthew D. Young, Ludmil B. Alexandrov, Sarah J. Farndon, Grace Collord, David C. Wedge, Inigo Martincorena, Susanna L. Cooke, Helen Davies, William Mifsud, Mathias Lidgren, Sancha Martin, Calli Latimer, Mark Maddison, Adam P. Butler, Jon W. Teague, Nischalan Pillay, Adam Shlien, Ultan McDermott, P. Andrew Futreal, Daniel Baumhoer, Olga Zaikova, Bodil Bjerkehagen, Ola Myklebost, M. Fernanda Amary, Roberto Tirabosco, Peter Van Loo, Michael R. Stratton, Adrienne M. Flanagan, Peter J. Campbell
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-8 (2017)
Osteosarcoma is a primary malignancy of bone that affects children and adults. Here, the authors sequence childhood and adult osteosarcomas, identifying mutations in insulin-like growth factor signalling genes and distinct genomic rearrangement profi
Externí odkaz:
https://doaj.org/article/4d580842711a47b9a0ba6bb379bd365f
Autor:
Sam Behjati, Gunes Gundem, David C. Wedge, Nicola D. Roberts, Patrick S. Tarpey, Susanna L. Cooke, Peter Van Loo, Ludmil B. Alexandrov, Manasa Ramakrishna, Helen Davies, Serena Nik-Zainal, Claire Hardy, Calli Latimer, Keiran M. Raine, Lucy Stebbings, Andy Menzies, David Jones, Rebecca Shepherd, Adam P. Butler, Jon W. Teague, Mette Jorgensen, Bhavisha Khatri, Nischalan Pillay, Adam Shlien, P. Andrew Futreal, Christophe Badie, ICGC Prostate Group, Ultan McDermott, G. Steven Bova, Andrea L. Richardson, Adrienne M. Flanagan, Michael R. Stratton, Peter J. Campbell
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-8 (2016)
Ionizing radiation may induce irreparable DNA damage leading to cancer. Here, the authors identify a specific signature of mutations arising in patients exposed to ionizing radiation and suggest that radiation-induced tumorigenesis is associated with
Externí odkaz:
https://doaj.org/article/6591661632a94c5d9e36a5a48f8dcf2c
Autor:
Adam Shlien, Keiran Raine, Fabio Fuligni, Roland Arnold, Serena Nik-Zainal, Serge Dronov, Lira Mamanova, Andrej Rosic, Young Seok Ju, Susanna L. Cooke, Manasa Ramakrishna, Elli Papaemmanuil, Helen R. Davies, Patrick S. Tarpey, Peter Van Loo, David C. Wedge, David R. Jones, Sancha Martin, John Marshall, Elizabeth Anderson, Claire Hardy, Violetta Barbashina, Samuel A.J.R. Aparicio, Torill Sauer, Øystein Garred, Anne Vincent-Salomon, Odette Mariani, Sandrine Boyault, Aquila Fatima, Anita Langerød, Åke Borg, Gilles Thomas, Andrea L. Richardson, Anne-Lise Børresen-Dale, Kornelia Polyak, Michael R. Stratton, Peter J. Campbell
Publikováno v:
Cell Reports, Vol 16, Iss 7, Pp 2032-2046 (2016)
Disordered transcriptomes of cancer encompass direct effects of somatic mutation on transcription, coordinated secondary pathway alterations, and increased transcriptional noise. To catalog the rules governing how somatic mutation exerts direct trans
Externí odkaz:
https://doaj.org/article/4492535398b04897a7bfaecb4a9c01d9
Autor:
Jozef Gecz, Raman Kumar, Roger E Stevenson, Michael Field, Michael J Friez, Susan Sklower Brooks, Monica J Basehore, Lesley C Adès, Courtney Sebold, Stephen McGee, Samantha Saxon, Cindy Skinner, Maria E Craig, Lucy Murray, Richard J Simensen, Ying Yzu Yap, Marie A Shaw, Alison Gardner, Mark Corbett, Matthias Bosshard, Barbara van Loon, Patrick S Tarpey, Fatima Abidi, Charles E Schwartz
Publikováno v:
BMJ Open, Vol 6, Iss 4 (2016)
Background X linked intellectual disability (XLID) syndromes account for a substantial number of males with ID. Much progress has been made in identifying the genetic cause in many of the syndromes described 20–40 years ago. Next generation sequenc
Externí odkaz:
https://doaj.org/article/63e513f726c64e4db29d23d9f58c5f6e
Autor:
Young Seok Ju, Ludmil B Alexandrov, Moritz Gerstung, Inigo Martincorena, Serena Nik-Zainal, Manasa Ramakrishna, Helen R Davies, Elli Papaemmanuil, Gunes Gundem, Adam Shlien, Niccolo Bolli, Sam Behjati, Patrick S Tarpey, Jyoti Nangalia, Charles E Massie, Adam P Butler, Jon W Teague, George S Vassiliou, Anthony R Green, Ming-Qing Du, Ashwin Unnikrishnan, John E Pimanda, Bin Tean Teh, Nikhil Munshi, Mel Greaves, Paresh Vyas, Adel K El-Naggar, Tom Santarius, V Peter Collins, Richard Grundy, Jack A Taylor, D Neil Hayes, David Malkin, ICGC Breast Cancer Group, ICGC Chronic Myeloid Disorders Group, ICGC Prostate Cancer Group, Christopher S Foster, Anne Y Warren, Hayley C Whitaker, Daniel Brewer, Rosalind Eeles, Colin Cooper, David Neal, Tapio Visakorpi, William B Isaacs, G Steven Bova, Adrienne M Flanagan, P Andrew Futreal, Andy G Lynch, Patrick F Chinnery, Ultan McDermott, Michael R Stratton, Peter J Campbell
Publikováno v:
eLife, Vol 3 (2014)
Recent sequencing studies have extensively explored the somatic alterations present in the nuclear genomes of cancers. Although mitochondria control energy metabolism and apoptosis, the origins and impact of cancer-associated mutations in mtDNA are u
Externí odkaz:
https://doaj.org/article/a97bb2e0fa0f4eb19b17cd3f405b0385
Autor:
G. A. Amos Burke, Grace Collord, Peter J. Campbell, Matthew D. Young, Thomas J. Mitchell, Thomas R. W. Oliver, Kathy Pritchard-Jones, P. S. Tarpey, Karin Straathof, Mark F. H. Brougham, Dyanne Rampling, Tim H. H. Coorens, Grant D. Stewart, Imran Mushtaq, Reem Al-Saadi, Kourosh Saeb-Parsy, Anne Y. Warren, Giuseppe Barone, Johannes Visser, Neil J. Sebire, Christine Thevanesan, Suzanne Tugnait, Inigo Martincorena, Taryn D. Treger, Michael R. Stratton, Nicholas Coleman, Sam Behjati, Luiza Moore, Maxine G. B. Tran, Minou Oostveen, James Nicholson, Alex Cagan, John Anderson, Liz Hook, Naima Smeulders, Yvette Hooks, Mette Jorgensen, Ben C Reynolds, David C. Wedge, Tanzina Chowdhury, Jarno Drost
Publikováno v:
Coorens, T H H, Treger, T D, Al-Saadi, R, Moore, L, Tran, M G B, Mitchell, T J, Tugnait, S, Thevanesan, C, Young, M D, Oliver, T R W, Oostveen, M, Collord, G, Tarpey, P S, Cagan, A, Hooks, Y, Brougham, M, Reynolds, B C, Barone, G, Anderson, J, Jorgensen, M, Burke, G A A, Visser, J, Nicholson, J C, Smeulders, N, Mushtaq, I, Stewart, G D, Campbell, P J, Wedge, D C, Martincorena, I, Rampling, D, Hook, L, Warren, A Y, Coleman, N, Chowdhury, T, Sebire, N, Drost, J, Saeb-Parsy, K, Stratton, M R, Straathof, K, Pritchard-Jones, K & Behjati, S 2019, ' Embryonal precursors of Wilms tumor ', Science . https://doi.org/10.1126/science.aax1323
A childhood tumor—from the beginning Many adult cancers arise from clonal expansions of mutant cells in normal tissue. These premalignant expansions are defined by somatic mutations shared by the cancers. Whether pediatric cancers originate in a si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3f201189b3325d9d9654d4a32fcb019
https://pubmed.ncbi.nlm.nih.gov/31853055
https://pubmed.ncbi.nlm.nih.gov/31853055
Autor:
Mark Maddison, Heather P. Harding, Ming-Qing Du, Athar Aziz, David Bloxham, Kate Hill, Brian J. P. Huntly, Paola Guglielmelli, Charles E. Massie, David G. Kent, Bruce W. S. Robinson, Kim Orchard, Edward Avezov, Gunes Gundem, Nicholas C.P. Cross, Jonathon Hinton, Jyoti Nangalia, P Van Loo, David Ron, L. Mudie, Sarah O’Meara, E J Baxter, Stephen J. Loughran, Anthony R. Green, Christina A. Ortmann, Claire N. Harrison, Clodagh Keohane, David R. Jones, Karoline Kollmann, Anna L. Godfrey, David C. Wedge, D. Dimitropoulou, Inigo Martincorena, M. Bianchi, Alessandro M. Vannucchi, Mel Greaves, Juan Li, Cathy MacLean, Elli Papaemmanuil, Peter J. Campbell, Amy V. Jones, P. S. Tarpey, Keiran Raine, David G. Bowen, Francesca L. Nice, Yvonne Silber, Adam Butler, Jon W. Teague, Sudhir Tauro, J.D. Fitzpatrick, Stuart McLaren, C.T. Goudie
Publikováno v:
The New England Journal of Medicine, 369, 25, pp. 2391-405
The New England Journal of Medicine, 369, 2391-405
The New England Journal of Medicine, 369, 2391-405
Item does not contain fulltext BACKGROUND: Somatic mutations in the Janus kinase 2 gene (JAK2) occur in many myeloproliferative neoplasms, but the molecular pathogenesis of myeloproliferative neoplasms with nonmutated JAK2 is obscure, and the diagnos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ac0501a77ea3dce575fb3007c9b5580
https://hdl.handle.net/2066/126260
https://hdl.handle.net/2066/126260
Autor:
P S Tarpey, J. Dyer, S M Gribble, Patrick J. Barker, R B Beechey, I. S. Wood, Soraya P. Shirazi-Beechey, D. Scott
Publikováno v:
Biochemical Society Transactions. 22:655-658
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::34cbee94c069e6fc8ab63000d05d0e85
https://doi.org/10.1042/bst0220655
https://doi.org/10.1042/bst0220655