Zobrazeno 1 - 10
of 211
pro vyhledávání: '"P S Sohal"'
Autor:
Ahmed M. Abdelaal, Ikjot S. Sohal, Shreyas G. Iyer, Kasireddy Sudarshan, Esteban A. Orellana, Kenan E. Ozcan, Andrea P. dos Santos, Philip S. Low, Andrea L. Kasinski
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 35, Iss 2, Pp 102193- (2024)
Use of tumor-suppressive microRNAs (miRNAs) as anti-cancer agents is hindered by the lack of effective delivery vehicles, entrapment of the miRNA within endocytic compartments, and rapid degradation of miRNA by nucleases. To address these issues, we
Externí odkaz:
https://doaj.org/article/c4e68e8c068a410f86d873750e696cff
Publikováno v:
Health Science Reports, Vol 7, Iss 5, Pp n/a-n/a (2024)
Abstract Background Patients' satisfaction with health services is considered an essential element for hospital setup as it measures its performance and quality of care. Thus, evaluation of patients' satisfaction has become a basic concern of clinica
Externí odkaz:
https://doaj.org/article/531e291001e84f8cb78c2224c6b72610
Autor:
Gang Liu, Tatt Jhong Haw, Malcolm R. Starkey, Ashleigh M. Philp, Stelios Pavlidis, Christina Nalkurthi, Prema M. Nair, Henry M. Gomez, Irwan Hanish, Alan CY. Hsu, Elinor Hortle, Sophie Pickles, Joselyn Rojas-Quintero, Raul San Jose Estepar, Jacqueline E. Marshall, Richard Y. Kim, Adam M. Collison, Joerg Mattes, Sobia Idrees, Alen Faiz, Nicole G. Hansbro, Ryutaro Fukui, Yusuke Murakami, Hong Sheng Cheng, Nguan Soon Tan, Sanjay H. Chotirmall, Jay C. Horvat, Paul S. Foster, Brian GG. Oliver, Francesca Polverino, Antonio Ieni, Francesco Monaco, Gaetano Caramori, Sukhwinder S. Sohal, Ken R. Bracke, Peter A. Wark, Ian M. Adcock, Kensuke Miyake, Don D. Sin, Philip M. Hansbro
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-24 (2023)
Abstract Toll-like receptor 7 (TLR7) is known for eliciting immunity against single-stranded RNA viruses, and is increased in both human and cigarette smoke (CS)-induced, experimental chronic obstructive pulmonary disease (COPD). Here we show that th
Externí odkaz:
https://doaj.org/article/c49c73a4f4614f95ae1cab28b0686048
Autor:
Ikjot S. Sohal, Andrea L. Kasinski
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Extracellular vesicles have undergone a paradigm shift from being considered as ‘waste bags’ to being central mediators of cell-to-cell signaling in homeostasis and several pathologies including cancer. Their ubiquitous nature, ability to cross b
Externí odkaz:
https://doaj.org/article/802469835074491f88b754863f08d3cf
Autor:
Theodore S. Kapellos, Kevin Baßler, Wataru Fujii, Christina Nalkurthi, Anna C. Schaar, Lorenzo Bonaguro, Tal Pecht, Izabela Galvao, Shobhit Agrawal, Adem Saglam, Erica Dudkin, Amit Frishberg, Elena de Domenico, Arik Horne, Chantal Donovan, Richard Y. Kim, David Gallego-Ortega, Tessa E. Gillett, Meshal Ansari, Jonas Schulte-Schrepping, Nina Offermann, Ignazio Antignano, Burcu Sivri, Wenying Lu, Mathew S. Eapen, Martina van Uelft, Collins Osei-Sarpong, Maarten van den Berge, Hylke C. Donker, Harry J.M. Groen, Sukhwinder S. Sohal, Johanna Klein, Tina Schreiber, Andreas Feißt, Ali Önder Yildirim, Herbert B. Schiller, Martijn C. Nawijn, Matthias Becker, Kristian Händler, Marc Beyer, Melania Capasso, Thomas Ulas, Jan Hasenauer, Carmen Pizarro, Fabian J. Theis, Philip M. Hansbro, Dirk Skowasch, Joachim L. Schultze
Publikováno v:
Cell Reports, Vol 42, Iss 6, Pp 112525- (2023)
Summary: Systemic inflammation is established as part of late-stage severe lung disease, but molecular, functional, and phenotypic changes in peripheral immune cells in early disease stages remain ill defined. Chronic obstructive pulmonary disease (C
Externí odkaz:
https://doaj.org/article/de07677bc6c241f3a6d5cd66f2c12fd0
Publikováno v:
Cells, Vol 13, Iss 1, p 52 (2023)
The mammalian target of rapamycin (mTOR) signaling pathway is a powerful regulator of cell proliferation, growth, synapse maintenance and cell fate. While intensely studied for its role in cancer, the role of mTOR signaling is just beginning to be un
Externí odkaz:
https://doaj.org/article/87376a05024d4b78891e1950a02b9768
Autor:
Shyam K Poudel, Roshan Padmanabhan, Heloni Dave, Kathryn Guinta, Tyler Stevens, Madhusudhan R Sanaka, Prabhleen Chahal, Davendra P S Sohal, Alok A Khorana, Charis Eng
Publikováno v:
PLoS ONE, Vol 18, Iss 4, p e0283021 (2023)
BackgroundThe prognostic and pathophysiologic significance of the biliary microbiota in pancreaticobiliary malignancies is little understood. Our goal was to find malignancy-related microbiomic fingerprints in bile samples taken from patients with be
Externí odkaz:
https://doaj.org/article/2d617dcb1c63470cb21d52dc6468854f
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Neuronal activity in auditory cortex is often highly synchronous between neighboring neurons. Such coordinated activity is thought to be crucial for information processing. We determined the functional properties of coordinated neuronal ense
Externí odkaz:
https://doaj.org/article/2762375115b24b1398ed54f66ac09eba
Autor:
Ruchi Malik, Emily Ling-Lin Pai, Anna N Rubin, April M Stafford, Kartik Angara, Petros Minasi, John L. Rubenstein, Vikaas S Sohal, Daniel Vogt
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Although cortical GABAergic interneuron (CIN) dysfunction is implicated in several neuropsychiatric disorders, we still know very little about how they attain their unique properties or how their dysfunction impacts neuropsychiatric disorders. In thi
Externí odkaz:
https://doaj.org/article/80b4682b9d2d4e25bfb4a1bda0b1e7cc
Autor:
Zishuo Ian Hu, Johanna C. Bendell, Andrea Bullock, Noelle K. LoConte, Hassan Hatoum, Paul Ritch, Hugo Hool, Joseph W. Leach, James Sanchez, Davendra P. S. Sohal, John Strickler, Ravindranath Patel, Andrea Wang‐Gillam, Irfan Firdaus, Kenneth H. Yu, Ann M. Kapoun, Eric Holmgren, Lei Zhou, Jakob Dupont, Vincent Picozzi, Vaibhav Sahai, Eileen M. O'Reilly
Publikováno v:
Cancer Medicine, Vol 8, Iss 11, Pp 5148-5157 (2019)
Abstract Purpose Notch signaling dysregulation is implicated in the development of pancreatic adenocarcinoma (PDAC). Tarextumab is a fully human IgG2 antibody that inhibits Notch2/3 receptors. Patients and Methods Aphase 2, randomized, placebo‐cont
Externí odkaz:
https://doaj.org/article/65d331d0de7c4b2799fe21f23c85e265