Zobrazeno 1 - 10
of 50
pro vyhledávání: '"P S Sharp"'
Autor:
Richard N. Bohnsack, Sandeep K. Misra, Jianfang Liu, Mayumi Ishihara-Aoki, Michaela Pereckas, Kazuhiro Aoki, Gang Ren, Joshua S. Sharp, Nancy M. Dahms
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract The cation-independent mannose 6-phosphate receptor (CI-MPR) is clinically significant in the treatment of patients with lysosomal storage diseases because it functions in the biogenesis of lysosomes by transporting mannose 6-phosphate (M6P)
Externí odkaz:
https://doaj.org/article/35234b80f7a143668b071c3cf37ff669
Autor:
Tyler Sheetz, Dinah Diab, Alicia Scimeca, Fara Bellows, David S. Sharp, Cheryl T. Lee, Tasha Posid
Publikováno v:
Frontiers in Urology, Vol 3 (2023)
BackgroundUrology is an increasingly competitive specialty that procures a highly selected and clinically excellent cohort of residents. However, other training needs such as leadership and professional development go underrecognized despite an ident
Externí odkaz:
https://doaj.org/article/6baca92d55fe425db549d730ed7f37ef
Autor:
Niloofar Abolhasani Khaje, Alexander Eletsky, Sarah E. Biehn, Charles K. Mobley, Monique J. Rogals, Yoonkyoo Kim, Sushil K. Mishra, Robert J. Doerksen, Steffen Lindert, James H. Prestegard, Joshua S. Sharp
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-8 (2022)
A mass spectrometry-based method guides computational modeling for de novo protein structure prediction.
Externí odkaz:
https://doaj.org/article/c2ada858bcc842d6afa56065cc8b866e
Autor:
Kaituo Wang, Robert Dagil, Thomas Lavstsen, Sandeep K. Misra, Charlotte B. Spliid, Yong Wang, Tobias Gustavsson, Daniel R. Sandoval, Elena Ethel Vidal-Calvo, Swati Choudhary, Mette Ø Agerbaek, Kresten Lindorff-Larsen, Morten A. Nielsen, Thor G. Theander, Joshua S. Sharp, Thomas Mandel Clausen, Pontus Gourdon, Ali Salanti
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
In placental malaria, interactions between parasite protein VAR2CSA and human glycosaminoglycan chondroitin sulfate A (CS) sequesters infected red blood cells in the placenta. Here, the authors provide cryo-EM structures of VAR2CSA and placental CS,
Externí odkaz:
https://doaj.org/article/fd67b0fdc13e4bbbbe14bbcaf2e9d8b8
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract Considered a key taxon in soil and marine microbial communities, myxobacteria exist as coordinated swarms that utilize a combination of lytic enzymes and specialized metabolites to facilitate predation of microbes. This capacity to produce s
Externí odkaz:
https://doaj.org/article/d1514883bfe143359c0ed0f49fa7ec26
Autor:
Elisabeth A Marnik, Miguel V Almeida, P Giselle Cipriani, George Chung, Edoardo Caspani, Emil Karaulanov, Hin Hark Gan, John Zinno, Ida J Isolehto, Fridolin Kielisch, Falk Butter, Catherine S Sharp, Roisin M Flanagan, Frederic X Bonnet, Fabio Piano, René F Ketting, Kristin C Gunsalus, Dustin L Updike
Publikováno v:
PLoS Genetics, Vol 18, Iss 6, p e1010245 (2022)
LOTUS and Tudor domain containing proteins have critical roles in the germline. Proteins that contain these domains, such as Tejas/Tapas in Drosophila, help localize the Vasa helicase to the germ granules and facilitate piRNA-mediated transposon sile
Externí odkaz:
https://doaj.org/article/71709158c8ad428c89af9008c7d82035
Autor:
Osman Shabir, Ben Pendry, Llywelyn Lee, Beth Eyre, Paul S Sharp, Monica A Rebollar, David Drew, Clare Howarth, Paul R Heath, Stephen B Wharton, Sheila E Francis, Jason Berwick
Publikováno v:
eLife, Vol 11 (2022)
Neurovascular coupling is a critical brain mechanism whereby changes to blood flow accompany localised neural activity. The breakdown of neurovascular coupling is linked to the development and progression of several neurological conditions including
Externí odkaz:
https://doaj.org/article/92e57f89b041496cb62439a786902073
Autor:
Corie Y. Ralston, Joshua S. Sharp
Publikováno v:
Antibodies, Vol 11, Iss 4, p 71 (2022)
Commercial monoclonal antibodies are growing and important components of modern therapies against a multitude of human diseases. Well-known high-resolution structural methods such as protein crystallography are often used to characterize antibody str
Externí odkaz:
https://doaj.org/article/30a0e4946d074ee0875b4d54db62c2e5
Autor:
Dipanwita Mitra, Mohammad H Hasan, John T Bates, Michael A Bierdeman, Dallas R Ederer, Rinkuben C Parmar, Lauren A Fassero, Quntao Liang, Hong Qiu, Vaibhav Tiwari, Fuming Zhang, Robert J Linhardt, Joshua S Sharp, Lianchun Wang, Ritesh Tandon
Publikováno v:
PLoS Pathogens, Vol 17, Iss 8, p e1009803 (2021)
Several enveloped viruses, including herpesviruses attach to host cells by initially interacting with cell surface heparan sulfate (HS) proteoglycans followed by specific coreceptor engagement which culminates in virus-host membrane fusion and virus
Externí odkaz:
https://doaj.org/article/494ffbd93696441bb2b9787e8edc5fbf
Autor:
Barbara I. Adaikpoh, Shukria Akbar, Hanan Albataineh, Sandeep K. Misra, Joshua S. Sharp, D. Cole Stevens
Publikováno v:
Frontiers in Microbiology, Vol 11 (2020)
Chemical exchanges between plants and microbes within rhizobiomes are critical to the development of community structure. Volatile root exudates such as the phytohormone methyljasmonate (MeJA) contribute to various plant stress responses and have bee
Externí odkaz:
https://doaj.org/article/dc0af855e12b46fcaa97581fd34ab518