Empirical single-cell tracking and cell-fate simulation reveal dual roles of p53 in tumor suppression

Autor: Ann Rancourt, Sachiko Sato, Masahiko S Satoh

Publikováno v: eLife, Vol 11 (2022)

The tumor suppressor p53 regulates various stress responses via increasing its cellular levels. The lowest p53 levels occur in unstressed cells; however, the functions of these low levels remain unclear. To investigate the functions, we used empirica

Externí odkaz: https://doaj.org/article/2f59abbeea904ebea27cedbcb7290121

Galectin-3 enhances neutrophil motility and extravasation into the airways during Aspergillus fumigatus infection.

Autor: Brendan D Snarr, Guillaume St-Pierre, Benjamin Ralph, Mélanie Lehoux, Yukiko Sato, Ann Rancourt, Takahiro Takazono, Shane R Baistrocchi, Rachel Corsini, Matthew P Cheng, Michele Sugrue, Lindsey R Baden, Koichi Izumikawa, Hiroshi Mukae, John R Wingard, Irah L King, Maziar Divangahi, Masahiko S Satoh, Bryan G Yipp, Sachiko Sato, Donald C Sheppard

Publikováno v: PLoS Pathogens, Vol 16, Iss 8, p e1008741 (2020)

Aspergillus fumigatus is an opportunistic mold that infects patients who are immunocompromised or have chronic lung disease, causing significant morbidity and mortality in these populations. While the factors governing the host response to A. fumigat

Externí odkaz: https://doaj.org/article/414657841db046fa861b75d2c1b81a56

Dose-dependent spatiotemporal responses of mammalian cells to an alkylating agent.

Autor: Ann Rancourt, Sachiko Sato, Masahiko S Satoh

Publikováno v: PLoS ONE, Vol 14, Iss 3, p e0214512 (2019)

Cultured cell populations are composed of heterogeneous cells, and previous single-cell lineage tracking analysis of individual HeLa cells provided empirical evidence for significant heterogeneity of the rate of cell proliferation and induction of ce

Externí odkaz: https://doaj.org/article/dd2ebc8a57a6431d9ffc8f9c93cdd0be

Effects of complement activation in the isolated heart. Role of the terminal complement components

Autor: Jonathon W. Homeister, P. S. Satoh, Benedict R. Lucchesi

Publikováno v: Circulation Research. 71:303-319

The mechanisms of the complement-mediated myocardial injury associated with ischemia and reperfusion have not been elucidated fully. Complement activation may directly mediate injury through actions of the anaphylatoxins C3a and C5a or generation of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb67a90f3acd453c2b2624b5e85a20fb
https://doi.org/10.1161/01.res.71.2.303

Patents and literature

Autor: Robert J. Linhardt, J. P. Albarella, L. H. D. Anderson, A. Paau, S. G. Platt, L. Sequeira, T. M. Ranki, H. E. Soderlund, E. L. Sheldon, C. H. Levenson, K. B. Mullis, H. Rapoport, R. M. Watson, K. K. Yabusaki, S. T. Isaacs, null Gamper, B. Howard, R. D. Armenia, I. Gibbons, T. S. Baker, S. R. Abbott, J. G. Simpson, J. F. Wright, M. J. Powell, J. D. Baldeschwieler, R. C. Gamble, A. M. Lin, G. W. Tin, T. O. Baldwin, T. F. Holzman, P. S. Satoh, F. S. Yein, M. J. Block, T. B. Hirschfeld, J. A. Burton, B. Hoop, M. S. Chagnon, E. V. Grotnan, L. Josephson, R. A. Whitehead, H. M. Chandler, K. Healey, J. G. R. Hurrell, T. W. Chang, A. Deutsch, N. Dorsey, S. E. Diamond, F. J. Regina, W. A. Frey, D. M. Simons, A. E. Gadow, W. G. Wood, J. C. Hinshaw, J. L. Toner, G. A. Reynolds, A. Karmen, F. D. Lasky, D. Kerschensteiner, C. L. Kirkemo, M. T. Shipchandler, K. M. Kosak, L. J. Kricka, G. H. G. H. Thorpe, T. P. Whitehead, V. T. Kung, D. E. Canova, P. Lau-Hon-Peng, E. K. Yang, H. W. Jacobson, D. F. Nicoli, V. B. Elings, M. Parham, W. J. Warren, K. Rokugawa, C. H. Self, D. Tokinaga, T. Kobayashi, K. Imai, Y. G. Tsay, V. D. Shah, C. H. J. Wang, S. D. Stroupe, M. E. Jolley, R. F. Zuk, D. J. Litman, P. Fossati, A. Freeman, R. Tor, J. J. Gallacher, I. J. Higgins, H. A. O. Hill, E. V. Plotkin, D. J. Page, N. J. Walton, D. Whitford, N. Itoh, K. Matsunaga, Y. Karasawa, Y. Takata, H. Kusakabe, H. Yamauchi, Y. Midorikawa, T. P. Malloy, L. J. DeFilippi, R. Riffer, J. L. Seago, H. Watanabe, N. Mitsuhida, M. Andoh, H. Matsumoto, P. F. Wegfahrt

Publikováno v: Applied Biochemistry and Biotechnology. 15:279-295

Bioassays, including immunoassays, enzyme assays, and assays using enzyme electrodes, and nucleic acid hybridization probes have been the subject of considerable industrial and academic research. New bioassay methods have applications in the medical,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::14eb6ca48f2f7f748255893c30d07aa3
https://doi.org/10.1007/bf02798455