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Autor:
Xia Sheng, Hatice Zeynep Nenseth, Su Qu, Omer F. Kuzu, Turid Frahnow, Lukas Simon, Stephanie Greene, Qingping Zeng, Ladan Fazli, Paul S. Rennie, Ian G. Mills, Håvard Danielsen, Fabian Theis, John B. Patterson, Yang Jin, Fahri Saatcioglu
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-3 (2024)
Externí odkaz:
https://doaj.org/article/3fde716d893d4f1e9d0bb5dad157a6f5
Autor:
Kevin J. Tam, Liangliang Liu, Michael Hsing, Kush Dalal, Daksh Thaper, Brian McConeghy, Parvin Yenki, Satyam Bhasin, James W. Peacock, Yuzhuo Wang, Artem Cherkasov, Paul S. Rennie, Martin E. Gleave, Christopher J. Ong
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract FOXA1 is a pioneer transcription factor that is frequently mutated in prostate, breast, bladder, and salivary gland malignancies. Indeed, metastatic castration-resistant prostate cancer (mCRPC) commonly harbour FOXA1 mutations with a prevale
Externí odkaz:
https://doaj.org/article/04472dd65cc24c0c8a00dc7c0f4fd55c
Publikováno v:
Earth System Science Data, Vol 13, Pp 631-644 (2021)
eLTER was a “Horizon 2020” project with the aim of advancing the development of long-term ecosystem research infrastructure in Europe. This paper describes how eLTER Information System infrastructure has been expanded by a climate service data pr
Externí odkaz:
https://doaj.org/article/dd00708e719b4b30b25ab6297ea5f309
Autor:
S. Rennie, C. Andrews, S. Atkinson, D. Beaumont, S. Benham, V. Bowmaker, J. Dick, B. Dodd, C. McKenna, D. Pallett, R. Rose, S. M. Schäfer, T. Scott, C. Taylor, H. Watson
Publikováno v:
Earth System Science Data, Vol 12, Pp 87-107 (2020)
Long-term datasets of integrated environmental variables, co-located together, are relatively rare. The UK Environmental Change Network (ECN) was launched in 1992 and provides the UK with its only long-term integrated environmental monitoring and res
Externí odkaz:
https://doaj.org/article/a90ac462baf94b00968929c08983fcd9
Publikováno v:
British Dental Journal; May 2021, Vol. 230 Issue: 10 p640-641, 2p
Autor:
Mariia Radaeva, Huifang Li, Eric LeBlanc, Kush Dalal, Fuqiang Ban, Fabrice Ciesielski, Bonny Chow, Helene Morin, Shannon Awrey, Kriti Singh, Paul S. Rennie, Nada Lallous, Artem Cherkasov
Publikováno v:
Cells, Vol 11, Iss 18, p 2785 (2022)
The mutation-driven transformation of clinical anti-androgen drugs into agonists of the human androgen receptor (AR) represents a major challenge for the treatment of prostate cancer patients. To address this challenge, we have developed a novel clas
Externí odkaz:
https://doaj.org/article/4aa1ebf257e04f9f8d6c4c6190d87376
Autor:
C.-H. Su, N. Eizenberg, P. Steinle, D. Jakob, P. Fox-Hughes, C. J. White, S. Rennie, C. Franklin, I. Dharssi, H. Zhu
Publikováno v:
Geoscientific Model Development, Vol 12, Pp 2049-2068 (2019)
The Bureau of Meteorology Atmospheric high-resolution Regional Reanalysis for Australia (BARRA) is the first atmospheric regional reanalysis over a large region covering Australia, New Zealand, and Southeast Asia. The production of the reanalysis wit
Externí odkaz:
https://doaj.org/article/f31299337f08481b973816c69b18dc17
Autor:
Xia Sheng, Hatice Zeynep Nenseth, Su Qu, Omer F. Kuzu, Turid Frahnow, Lukas Simon, Stephanie Greene, Qingping Zeng, Ladan Fazli, Paul S. Rennie, Ian G. Mills, Håvard Danielsen, Fabian Theis, John B. Patterson, Yang Jin, Fahri Saatcioglu
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Abstract Activation of endoplasmic reticulum (ER) stress/the unfolded protein response (UPR) has been linked to cancer, but the molecular mechanisms are poorly understood and there is a paucity of reagents to translate this for cancer therapy. Here,
Externí odkaz:
https://doaj.org/article/9ced43e64be24399a78c2bfb98856c69
Autor:
Mohammad Asim, Firas Tarish, Heather I. Zecchini, Kumar Sanjiv, Eleni Gelali, Charles E. Massie, Ajoeb Baridi, Anne Y. Warren, Wanfeng Zhao, Christoph Ogris, Leigh-Anne McDuffus, Patrice Mascalchi, Greg Shaw, Harveer Dev, Karan Wadhwa, Paul Wijnhoven, Josep V. Forment, Scott R. Lyons, Andy G. Lynch, Cormac O’Neill, Vincent R. Zecchini, Paul S. Rennie, Aria Baniahmad, Simon Tavaré, Ian G. Mills, Yaron Galanty, Nicola Crosetto, Niklas Schultz, David Neal, Thomas Helleday
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
Tumours with homologous recombination (HR) defects become sensitive to PARPi. Here, the authors show that androgen receptor (AR) regulates HR and AR inhibition activates the PARP pathway in vivo, thus inhibition of both AR and PARP is required for ef
Externí odkaz:
https://doaj.org/article/6dd1f31e993c4c649fd8af898835fe41