Zobrazeno 1 - 10
of 14
pro vyhledávání: '"P S Malo"'
Autor:
Xu Zhang, Vesselina M. Pearsall, Chase M. Carver, Elizabeth J. Atkinson, Benjamin D. S. Clarkson, Ethan M. Grund, Michelle Baez-Faria, Kevin D. Pavelko, Jennifer M. Kachergus, Thomas A. White, Renee K. Johnson, Courtney S. Malo, Alan M. Gonzalez-Suarez, Katayoun Ayasoufi, Kurt O. Johnson, Zachariah P. Tritz, Cori E. Fain, Roman H. Khadka, Mikolaj Ogrodnik, Diana Jurk, Yi Zhu, Tamara Tchkonia, Alexander Revzin, James L. Kirkland, Aaron J. Johnson, Charles L. Howe, E. Aubrey Thompson, Nathan K. LeBrasseur, Marissa J. Schafer
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
The authors discovered that proinflammatory senescent myeloid cells may recruit peripheral immune cells in the aged mouse brain. Their findings implicate senescent cell clearance as a strategy to counter aged brain inflammation and cognitive decline.
Externí odkaz:
https://doaj.org/article/563782268a174f9491ef229d9fd5e5e9
Autor:
Glennys V. Reynoso, David N. Gordon, Anurag Kalia, Cynthia C. Aguilar, Courtney S. Malo, Maya Aleshnick, Kimberly A. Dowd, Christian R. Cherry, John P. Shannon, Sophia M. Vrba, Autumn C. Holmes, Yael Alippe, Sonia Maciejewski, Kenichi Asano, Michael S. Diamond, Theodore C. Pierson, Heather D. Hickman
Publikováno v:
Cell Reports, Vol 42, Iss 2, Pp 112126- (2023)
Summary: To disseminate through the body, Zika virus (ZIKV) is thought to exploit the mobility of myeloid cells, in particular monocytes and dendritic cells. However, the timing and mechanisms underlying shuttling of the virus by immune cells remains
Externí odkaz:
https://doaj.org/article/1e565ee0ec8c4a429c99464dca821ac4
Autor:
A K Azad Khan, Jagannath Malo, Md Jahangir Alam, Salequl Islam, Md Abdul Mottalib, Md Mehedi Hasan Rocki, Ginok Barmon, Shamema Akter Tinni, Swapan K Barman, Tapas Sarker, Md Nayeemul Islam Khan, Kanakaraju Kaliannan, Muhammad Abul Hasanat, Salimur Rahman, Md Faruque Pathan, Madhu S Malo
Publikováno v:
BMJ Open Diabetes Research & Care, Vol 10, Iss 1 (2022)
Externí odkaz:
https://doaj.org/article/006e706154d14e2283ed77f839b9ba03
Autor:
Emma N. Goddery, Cori E. Fain, Chloe G. Lipovsky, Katayoun Ayasoufi, Lila T. Yokanovich, Courtney S. Malo, Roman H. Khadka, Zachariah P. Tritz, Fang Jin, Michael J. Hansen, Aaron J. Johnson
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
CD8 T cell infiltration of the central nervous system (CNS) is necessary for host protection but contributes to neuropathology. Antigen presenting cells (APCs) situated at CNS borders are thought to mediate T cell entry into the parenchyma during neu
Externí odkaz:
https://doaj.org/article/443b39ecb46d4a36a05a01c787ee7c3d
Autor:
Courtney S. Malo, Matthew A. Huggins, Emma N. Goddery, Heather M. A. Tolcher, Danielle N. Renner, Fang Jin, Michael J. Hansen, Larry R. Pease, Kevin D. Pavelko, Aaron J. Johnson
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Dendritic cell antigen presentation is central to CD8+ T cell responses, but surprisingly little is known about the requirement for this functionality in the central nervous system. Here, the authors use three different models of neuroinflammation to
Externí odkaz:
https://doaj.org/article/7bf1f249199b44a48e774d5c33748d09
Autor:
Marlies Schippers, Eduard Post, Ilse Eichhorn, Jitske Langeland, Leonie Beljaars, Madhu S. Malo, Richard A. Hodin, José Luis Millán, Yury Popov, Detlef Schuppan, Klaas Poelstra
Publikováno v:
Cells, Vol 9, Iss 12, p 2708 (2020)
Alkaline phosphatase (AP) activity is highly upregulated in plasma during liver diseases. Previously, we demonstrated that AP is able to detoxify lipopolysaccharide (LPS) by dephosphorylating its lipid A moiety. Because a role of gut-derived LPS in l
Externí odkaz:
https://doaj.org/article/aae3939d90614fc7bf583d46f08fcfc8
Autor:
Madhu S. Malo
Publikováno v:
EBioMedicine, Vol 2, Iss 12, Pp 2016-2023 (2015)
Mice deficient in intestinal alkaline phosphatase (IAP) develop type 2 diabetes mellitus (T2DM). We hypothesized that a high level of IAP might be protective against T2DM in humans. We determined IAP levels in the stools of 202 diabetic patients and
Externí odkaz:
https://doaj.org/article/880eb98562a041b3a90ccb5529ea6885
Autor:
Courtney S. Malo, Roman H. Khadka, Katayoun Ayasoufi, Fang Jin, Jackson E. AbouChehade, Michael J. Hansen, Raymond Iezzi, Kevin D. Pavelko, Aaron J. Johnson
Publikováno v:
Frontiers in Oncology, Vol 8 (2018)
Glioblastoma (GBM) is a lethal cancer of the central nervous system with a median survival rate of 15 months with treatment. Thus, there is a critical need to develop novel therapies for GBM. Immunotherapy is emerging as a promising therapeutic strat
Externí odkaz:
https://doaj.org/article/cfef3132d6954d7ba34f8c4c76252ca7
Autor:
Courtney S Malo, Danielle N Renner, April M Huseby Kelcher, Fang Jin, Michael J Hansen, Kevin D Pavelko, Aaron J Johnson
Publikováno v:
PLoS ONE, Vol 11, Iss 8, p e0162064 (2016)
Virus vector-based vaccination against tumor-specific antigens remains a promising therapeutic approach to overcome the immune suppressive tumor microenvironment. However, the extent that the desired CD8 T cell response against the targeted tumor ant
Externí odkaz:
https://doaj.org/article/1dfc8de581a0428bab4e518a13d107f1
Autor:
Brendan K Reed, Laura B Chopp, Courtney S Malo, Danielle N Renner, Virginia S Van Keulen, Megan A Girtman, Wendy N Nevala, Kevin D Pavelko, Diana Gil, Adam G Schrum, Aaron J Johnson, Larry R Pease
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0137984 (2015)
Antigen-specific T cell responses can be visualized using MHC:peptide multimers. In cases where robust T cell controls are not readily available to assess the integrity of multimer reagents prior to analyzing limited sample, the ability to assess the
Externí odkaz:
https://doaj.org/article/1fb448f2255f452cad3fed8f44b99cae