Zobrazeno 1 - 10
of 15
pro vyhledávání: '"P S, Western"'
Publikováno v:
BMC Biology, Vol 22, Iss 1, Pp 1-24 (2024)
Abstract Background Abnormalities of in utero testis development are strongly associated with reproductive health conditions, including male infertility and testis cancer. In mouse testes, SOX9 and FGF9 support Sertoli cell development, while VEGF si
Externí odkaz:
https://doaj.org/article/87033842ebcb4f02a0e3de5f29d5213a
Autor:
Ruby Oberin, Sigrid Petautschnig, Ellen G Jarred, Zhipeng Qu, Tesha Tsai, Neil A Youngson, Gabrielle Pulsoni, Thi T Truong, Dilini Fernando, Heidi Bildsoe, Rheannon O Blücher, Maarten van den Buuse, David K Gardner, Natalie A Sims, David L Adelson, Patrick S Western
Publikováno v:
eLife, Vol 13 (2024)
Germline epigenetic programming, including genomic imprinting, substantially influences offspring development. Polycomb Repressive Complex 2 (PRC2) plays an important role in Histone 3 Lysine 27 trimethylation (H3K27me3)-dependent imprinting, loss of
Externí odkaz:
https://doaj.org/article/76f117b6b7a24bfc9e0a47cd99baddff
Publikováno v:
BMC Biology, Vol 21, Iss 1, Pp 1-22 (2023)
Abstract Background Disrupted germline differentiation or compromised testis development can lead to subfertility or infertility and are strongly associated with testis cancer in humans. In mice, SRY and SOX9 induce expression of Fgf9, which promotes
Externí odkaz:
https://doaj.org/article/5fdde4b6e29544ef84dcfbc95872e4a6
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
Activin A, a TGFβ superfamily member, is important for normal testis development through its actions on Sertoli cell development. Our analyses of altered activin A mouse models indicated gonocyte abnormalities, implicating activin A as a key determi
Externí odkaz:
https://doaj.org/article/1cca202fbcd24948b73ee09bf267d8a9
Autor:
Jessica M. Stringer, Samuel C. Forster, Zhipeng Qu, Lexie Prokopuk, Moira K. O’Bryan, David K. Gardner, Stefan J. White, David Adelson, Patrick S. Western
Publikováno v:
BMC Biology, Vol 16, Iss 1, Pp 1-20 (2018)
Abstract Background Defining the mechanisms that establish and regulate the transmission of epigenetic information from parent to offspring is critical for understanding disease heredity. Currently, the molecular pathways that regulate epigenetic inf
Externí odkaz:
https://doaj.org/article/13dce132886940ca87b718091faecbb9
Autor:
Lexie Prokopuk, Jessica M. Stringer, Craig R. White, Rolf H. A. M. Vossen, Stefan J. White, Ana S. A. Cohen, William T. Gibson, Patrick S. Western
Publikováno v:
Clinical Epigenetics, Vol 10, Iss 1, Pp 1-14 (2018)
Abstract Background Investigating how epigenetic information is transmitted through the mammalian germline is the key to understanding how this information impacts on health and disease susceptibility in offspring. EED is essential for regulating the
Externí odkaz:
https://doaj.org/article/62884fb084604d299cae3ecb012060ec
Publikováno v:
Clinical Epigenetics, Vol 10, Iss 1, Pp 1-12 (2018)
Abstract Background Recently discovered drugs that target epigenetic modifying complexes are providing new treatment options for a range of cancers that affect patients of reproductive age. Although these drugs provide new therapies, it is likely tha
Externí odkaz:
https://doaj.org/article/91396ae93ead41f2832b5aaafc8ec844
Publikováno v:
F1000Research, Vol 7 (2018)
Epigenetic modifications, including DNA methylation and histone modifications, determine the way DNA is packaged within the nucleus and regulate cell-specific gene expression. The heritability of these modifications provides a memory of cell identity
Externí odkaz:
https://doaj.org/article/d2b3adbc33fa411f8e54b3a65860d9b4
Autor:
Shaghayegh Saeidi, Farnaz Shapouri, Robb U de Iongh, Franca Casagranda, Jessie M Sutherland, Patrick S Western, Eileen A McLaughlin, Mary Familari, Gary R Hime
Publikováno v:
PLoS ONE, Vol 13, Iss 1, p e0190925 (2018)
ESRP1 regulates alternative splicing, producing multiple transcripts from its target genes in epithelial tissues. It is upregulated during mesenchymal to epithelial transition associated with reprogramming of fibroblasts to iPS cells and has been lin
Externí odkaz:
https://doaj.org/article/44cde7960a234885be9fcc2e4cf31801
Autor:
Denise C Miles, Stephanie I Wakeling, Jessica M Stringer, Jocelyn A van den Bergen, Dagmar Wilhelm, Andrew H Sinclair, Patrick S Western
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e54606 (2013)
The developing testis provides an environment that nurtures germ cell development, ultimately ensuring spermatogenesis and fertility. Impacts on this environment are considered to underlie aberrant germ cell development and formation of germ cell tum
Externí odkaz:
https://doaj.org/article/e7f2b59458ea4d6b968f5ba8f98802d4