Zobrazeno 1 - 10
of 38
pro vyhledávání: '"P S, Reinach"'
Autor:
Loreena Rech, Tina Dietrich-Ntoukas, Peter S. Reinach, Tobias Brockmann, Uwe Pleyer, Stefan Mergler
Publikováno v:
Cells, Vol 13, Iss 16, p 1329 (2024)
The conjunctiva has immune-responsive properties to protect the eye from infections. Its innate immune system reacts against external pathogens, such as fungi. The complement factor C5a is an important contributor to the initial immune response. It i
Externí odkaz:
https://doaj.org/article/4233c55cb89f4d3f9472f31dea61d5c3
Autor:
Guangying Luo, Weiwei Xu, Xiaoyan Chen, Siqi Wang, Jiao Wang, Feng Dong, Dan-Ning Hu, Peter S. Reinach, Dongsheng Yan
Publikováno v:
Epigenetics, Vol 17, Iss 8, Pp 922-933 (2022)
RNA 5-methylcytosine (m5C) is a widespread post-transcriptional modification involved in diverse biological processes through controlling RNA metabolism. However, its roles in uveal melanoma (UM) remain unknown. Here, we describe the biological roles
Externí odkaz:
https://doaj.org/article/09adb7349e7b49c8ab239726e19811ed
Autor:
Shuai Yang, Weiwei Chen, Shanshan Jin, Guangying Luo, Xia Jing, Qi Liu, Peter S. Reinach, Jia Qu, Dongsheng Yan
Publikováno v:
Eye and Vision, Vol 9, Iss 1, Pp 1-15 (2022)
Abstract Background Corneal epithelial wound healing (CEWH) is vital for maintaining the integrity and barrier function of the cornea. Although histone modifications mediating gene expression patterns is fundamental in some other tissues, it remains
Externí odkaz:
https://doaj.org/article/7c8dbb8ff42d4c20b295eb123459a0a0
Autor:
Noushafarin Khajavi, Andreas Beck, Klea Riçku, Philipp Beyerle, Katharina Jacob, Sabrina F. Syamsul, Anouar Belkacemi, Peter S. Reinach, Pascale C.F. Schreier, Houssein Salah, Tanja Popp, Aaron Novikoff, Andreas Breit, Vladimir Chubanov, Timo D. Müller, Susanna Zierler, Thomas Gudermann
Publikováno v:
JCI Insight, Vol 8, Iss 3 (2023)
Most overweight individuals do not develop diabetes due to compensatory islet responses to restore glucose homeostasis. Therefore, regulatory pathways that promote β cell compensation are potential targets for treatment of diabetes. The transient re
Externí odkaz:
https://doaj.org/article/3e995b7dace7473fa3fc520fc567dc3c
Autor:
Noushafarin Khajavi, Klea Riçku, Pascale C. F. Schreier, Tanja Gentz, Philipp Beyerle, Emmanuel Cruz, Andreas Breit, Peter S. Reinach, Thomas Gudermann
Publikováno v:
Cells, Vol 12, Iss 13, p 1790 (2023)
Magnesium is an essential mediator of a vast number of critical enzymatic cellular reactions in the human body. Some clinical epidemiological studies suggest that hypomagnesemia accounts for declines in insulin secretion in patients with type 2 diabe
Externí odkaz:
https://doaj.org/article/1a0ea34db118460cbd75b1d806b530a7
Autor:
Qiongjie Cao, Weiwei Xu, Weiwei Chen, Dewei Peng, Qi Liu, Jing Dong, Peter S. Reinach, Dongsheng Yan
Publikováno v:
Eye and Vision, Vol 7, Iss 1, Pp 1-11 (2020)
Abstract Background MicroRNAs (miRNAs) play critical roles in corneal development and functional homeostasis. Our previous study identified miR-184 as one of the most highly expressed miRNAs in the corneal epithelium. Even though its expression level
Externí odkaz:
https://doaj.org/article/ce85ce4eef864f849501be87374bbaa0
Publikováno v:
Frontiers in Immunology, Vol 12 (2022)
The maintenance of normal vision is dependent on preserving corneal transparency. For this to occur, this tissue must remain avascular and its stromal architecture needs to be retained. Epithelial transparency is maintained provided the uppermost str
Externí odkaz:
https://doaj.org/article/f3d77dc6870046b68a958b26c213cea4
Autor:
Fuxin Zhao, Wei Chen, Hui Zhou, Peter S. Reinach, Yuhan Wang, Suh-Hang H. Juo, Zhenglin Yang, Anquan Xue, Yi Shi, Chung-Ling Liang, Changqing Zeng, Jia Qu, Xiangtian Zhou
Publikováno v:
Frontiers in Genetics, Vol 12 (2022)
Myopia is the most common cause of refractive error worldwide. High myopia is a severe type of myopia, which usually accompanies pathological changes in the fundus. To identify high myopia susceptibility genes, DNA-pooling based genome-wide associati
Externí odkaz:
https://doaj.org/article/a08961fdee9e4535b07e08d884c64463
Autor:
Xiaoya An, Guoliang Wang, Mengyi Jin, Xiaoping Zhou, Shubin Gao, Jingyao Chen, Peter S. Reinach, Zuguo Liu, Yuhua Xue, Cheng Li
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
It has been a long-standing challenge to obtain from cell cultures adequate amounts of mouse corneal epithelial cells (mCEC) to perform transplantation surgery. This limitation is attributable to the passage dependent declines in their proliferative
Externí odkaz:
https://doaj.org/article/7b565ca1058f46bf8403545243c0b1b1
Autor:
Jennifer Donau, Huan Luo, Iiris Virta, Annett Skupin, Margarita Pushina, Jana Loeffler, Frauke V. Haertel, Anupam Das, Thomas Kurth, Michael Gerlach, Dirk Lindemann, Peter S. Reinach, Stefan Mergler, Monika Valtink
Publikováno v:
Membranes, Vol 12, Iss 3, p 281 (2022)
The functional contribution of transient receptor potential vanilloid 4 (TRPV4) expression in maintaining human corneal endothelial cells (HCEC) homeostasis is unclear. Accordingly, we determined the effects of TRPV4 gene and protein overexpression o
Externí odkaz:
https://doaj.org/article/62217a0e5400493ab9c9ac586cf5c0f0