Zobrazeno 1 - 10
of 106
pro vyhledávání: '"P S, Portoghese"'
Autor:
Raini Dutta, Mary M. Lunzer, Jennifer L. Auger, Eyup Akgün, Philip S. Portoghese, Bryce A. Binstadt
Publikováno v:
Arthritis Research & Therapy, Vol 20, Iss 1, Pp 1-10 (2018)
Abstract Background Pain accompanies rheumatoid arthritis and other chronic inflammatory conditions and is difficult to manage. Although opioids provide potent analgesia, chronic opioid use can cause tolerance and addiction. Recent studies have demon
Externí odkaz:
https://doaj.org/article/52d8dea972c8455d9122c10989aa592a
Publikováno v:
Proceedings of the Society for Experimental Biology and Medicine. 224:93-101
Heroin produced antinociception in the tail flick test through mu receptors in the brain of ICR and CD-1 mice, a response inhibited by 3-O-methylnaltrexone. Tolerance to morphine was produced by subcutaneous morphine pellet implantation. By the third
Publikováno v:
Journal of Biological Chemistry. 268:23055-23058
The enkephalins, dynorphins, and endorphins are endogenous opioids which function as neurotransmitters, neuromodulators, and hormones and are involved in the perception of pain, modulation of behavior, and regulation of autonomic and neuroendocrine f
Autor:
T B, Adams, J, Doull, V J, Feron, J I, Goodman, L J, Marnett, I C, Munro, P M, Newberne, P S, Portoghese, R L, Smith, W J, Waddell, B M, Wagner
Publikováno v:
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 40(4)
This is the fifth in a series of safety evaluations performed by the Expert Panel of the Flavor and Extract Manufacturers Association (FEMA). In 1993, the Panel initiated a comprehensive program to re-evaluate the safety of more than 1700 GRAS flavor
Publikováno v:
Advances in experimental medicine and biology. 493
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 297(2)
The antidiarrheal and constipating effects of opiates are partly attributed to reductions in active anion secretion across the intestinal mucosa that are modulated by submucosal neurons. In this study, the opioid receptor mediating the actions of opi
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 297(1)
Opioid receptors (ORs) in the myenteric plexus mediate the antimotility actions of opioids in the small intestine. In this study, ORs modulating neurogenic circular muscle contractions in the porcine ileum were characterized by pharmacological and im
Publikováno v:
Organic letters. 2(6)
[formula: see text] The phenolic hydroxy group of opiate-derived ligands is of known importance for biological activity. On the basis of its putative role as a hydrogen-bonding donor in the interaction with opioid receptors, it was replaced with a su
Autor:
P, Newberne, R L, Smith, J, Doull, J I, Goodman, I C, Munro, P S, Portoghese, B M, Wagner, C S, Weil, L A, Woods, T B, Adams, C D, Lucas, R A, Ford
Publikováno v:
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 37(7)
This publication is the fourth in a series of safety evaluations performed by the Expert Panel of the Flavour and Extract Manufacturers' Association (FEMA). In 1993, the Panel initiated a comprehensive program to re-evaluate the safety of more than 1
Autor:
H. Nagase, P. S. Portoghese
Publikováno v:
The Journal of Organic Chemistry. 55:365-367