Zobrazeno 1 - 10
of 40
pro vyhledávání: '"P S, Mikkelsen"'
Autor:
Chaochao Chai, Langchao Liang, Nanna S. Mikkelsen, Wei Wang, Wandong Zhao, Chengcheng Sun, Rasmus O. Bak, Hanbo Li, Lin Lin, Fei Wang, Yonglun Luo
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-15 (2024)
Abstract A comprehensive investigation of ovarian cancer (OC) progression at the single-cell level is crucial for enhancing our understanding of the disease, as well as for the development of better diagnoses and treatments. Here, over half a million
Externí odkaz:
https://doaj.org/article/23ff22a4c6ce4ede80656bf694d0bea8
Autor:
Marie C.L. Sørensen, Mie M. Andersen, Klaus Rostgaard, Kjeld Schmiegelow, Torben S. Mikkelsen, Peder S. Wehner, Marianne Olsen, Signe H. Søegaard, Lisa L. Hjalgrim
Publikováno v:
Acta Oncologica, Vol 63, Iss 1 (2024)
Background: Survival of children with cancer has markedly improved over recent decades, largely due to intensified treatment regimes. The intensive treatment may, however, result in fatal complications. In this retrospective cohort study, we assessed
Externí odkaz:
https://doaj.org/article/17276a5b55aa46d7b47a219ead167085
Autor:
Alexander P. Underwood, Christina Sølund, Kivin Jacobsen, Alekxander Binderup, Carlota Fernandez-Antunez, Lotte S. Mikkelsen, Dilek Inekci, Signe Lysemose Villadsen, Jose A. S. Castruita, Mette Pinholt, Ulrik Fahnøe, Santseharay Ramirez, Liselotte Brix, Nina Weis, Jens Bukh
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
As severe acute respiratory coronavirus 2 (SARS-CoV-2) variants continue to emerge, it is important to characterize immune responses against variants which can inform on protection efficacies following booster vaccination. In this study, neutralizing
Externí odkaz:
https://doaj.org/article/f4f02d14888b456b8a2729d7250fc4fc
Autor:
Nanna S. Mikkelsen, Rasmus O. Bak
Publikováno v:
Journal of Biomedical Science, Vol 30, Iss 1, Pp 1-21 (2023)
Abstract Genome editing technologies hold great promise for numerous applications including the understanding of cellular and disease mechanisms and the development of gene and cellular therapies. Achieving high editing frequencies is critical to the
Externí odkaz:
https://doaj.org/article/b693a78456d743d8a27fd654c74f5c2c
Autor:
Nanna S. Mikkelsen, Sabina S. Hernandez, Trine I. Jensen, Jessica L. Schneller, Rasmus O. Bak
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 29, Iss , Pp 1-16 (2023)
CRISPR-Cas-mediated site-specific integration of transgenes by homology-directed repair (HDR) is challenging, especially in primary cells, where inferior editing efficiency may impede the development of gene- and cellular therapies. Various strategie
Externí odkaz:
https://doaj.org/article/f2b78d2a32624f20b177aadcf3362a66
Autor:
Randal K. Buddington, Thomas Wong, Karyl K. Buddington, Torben S. Mikkelsen, Xueyuan Cao, Scott C. Howard
Publikováno v:
Frontiers in Nephrology, Vol 3 (2023)
IntroductionEarly identification of compromised renal clearance caused by high-dose methotrexate (HDMTX) is essential for initiating timely interventions that can reduce acute kidney injury and MTX-induced systemic toxicity.MethodsWe induced acute ki
Externí odkaz:
https://doaj.org/article/d8de6fb5116947b98a24a086491b0f09
Publikováno v:
Hydrology and Earth System Sciences, Vol 26, Pp 5879-5898 (2022)
Simulation models are widely used in urban drainage engineering and research, but they are known to include errors and uncertainties that are not yet fully realised. Within the herein developed framework, we investigate model adequacy across multiple
Externí odkaz:
https://doaj.org/article/3d19938a731b4d83861edf1c98400c5a
Autor:
Nicolas Fossat, Emma A. Lundsgaard, Rui Costa, Lizandro R. Rivera-Rangel, Louise Nielsen, Lotte S. Mikkelsen, Santseharay Ramirez, Jens Bukh, Troels K.H. Scheel
Publikováno v:
Cell Reports, Vol 42, Iss 4, Pp 112282- (2023)
Summary: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has had a tremendous impact worldwide. Mapping virus-host interactions is critical to understand disease progression. MicroRNAs (miRNAs) are important RNA regulators,
Externí odkaz:
https://doaj.org/article/9104c227ccf9489d9493adb61ae0fb5f
Autor:
Alexander P. Underwood, Christina Sølund, Carlota Fernandez-Antunez, Signe Lysemose Villadsen, Lotte S. Mikkelsen, Ulrik Fahnøe, Signe Bollerup, Anni Assing Winckelmann, Uffe Vest Schneider, Alekxander Binderup, Greta Vizgirda, Anna-Louise Sørensen, Caroline Nørløv Vinten, Magnus Illum Dalegaard, Santseharay Ramirez, Nina Weis, Jens Bukh
Publikováno v:
EBioMedicine, Vol 89, Iss , Pp 104475- (2023)
Summary: Background: Given the importance of vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the prevention of severe coronavirus disease 2019 (COVID-19), detailed long-term analyses of neutralising antibody respon
Externí odkaz:
https://doaj.org/article/f0bd2b415d514ce0b6ceeba2a996b746
Publikováno v:
Water Science and Technology, Vol 85, Iss 6, Pp 1981-1998 (2022)
Digital twins of urban drainage systems require simulation models that can adequately replicate the physical system. All models have their limitations, and it is important to investigate when and where simulation results are acceptable and to communi
Externí odkaz:
https://doaj.org/article/684ba43808d84d5c878751d70d46fe61