Zobrazeno 1 - 10
of 129
pro vyhledávání: '"P S, Linsley"'
Autor:
Erin M. Witkop, Kirsten Diggins, Alice Wiedeman, Elisavet Serti, Gerald Nepom, Vivian H. Gersuk, Bryce Fuchs, S. Alice Long, Peter S. Linsley
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-14 (2024)
Abstract Distinct Natural Killer (NK)-like CD57+ and PD-1+ CD8+ exhausted-like T cell populations (Tex) have both been linked to beneficial immunotherapy response in autoimmune type 1 diabetes (T1D) patients. The origins and relationships between the
Externí odkaz:
https://doaj.org/article/8d3fb1a37da44494b3b4cd1c67e7d55e
Autor:
Peter S. Linsley, Maki Nakayama, Elisa Balmas, Janice Chen, Fariba Barahmand-pour-Whitman, Shubham Bansal, Ty Bottorff, Elisavet Serti, Cate Speake, Alberto Pugliese, Karen Cerosaletti
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Human type 1 diabetes (T1D) is caused by autoimmune attack on the insulin-producing pancreatic beta cells by islet antigen-reactive T cells. How human islet antigen-reactive (IAR) CD4+ memory T cells from peripheral blood affect T1D progress
Externí odkaz:
https://doaj.org/article/66f2c80699f6498b86e42acf78ab840a
Autor:
Sarah Alice Long, Virginia S. Muir, Britta E. Jones, Valerie Z. Wall, Alyssa Ylescupidez, Anne M. Hocking, Stephan Pribitzer, Jerill Thorpe, Bryce Fuchs, Alice E. Wiedeman, Megan Tatum, Katharina Lambert, Hannes Uchtenhagen, Cate Speake, Bernard Ng, Alexander T. Heubeck, Troy R. Torgerson, Adam K. Savage, Michael A. Maldonado, Neelanjana Ray, Vadim Khaychuk, Jinqi Liu, Peter S. Linsley, Jane H. Buckner
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Exhausted CD8 T cells (TEX) are associated with worse outcome in cancer yet better outcome in autoimmunity. Building on our past findings of increased TIGIT+KLRG1+ TEX with teplizumab therapy in type 1 diabetes (T1D), in the absence of treatment we f
Externí odkaz:
https://doaj.org/article/848afa4859044e9fb280078686f378e7
Autor:
Elisa Balmas, Janice Chen, Alex K. Hu, Hannah A. DeBerg, Mario G. Rosasco, Vivian H. Gersuk, Elisavet Serti, Cate Speake, Carla J. Greenbaum, Gerald T. Nepom, Peter S. Linsley, Karen Cerosaletti
Publikováno v:
JCI Insight, Vol 8, Iss 21 (2023)
Variation in the preservation of β cell function in clinical trials in type 1 diabetes (T1D) has emphasized the need to define biomarkers to predict treatment response. The T1DAL trial targeted T cells with alefacept (LFA-3–Ig) and demonstrated C-
Externí odkaz:
https://doaj.org/article/fc5124fb6eab4bc1a3e7082177f0b113
Autor:
Laura M. Jacobsen, Kirsten Diggins, Lori Blanchfield, James McNichols, Daniel J. Perry, Jason Brant, Xiaoru Dong, Rhonda Bacher, Vivian H. Gersuk, Desmond A. Schatz, Mark A. Atkinson, Clayton E. Mathews, Michael J. Haller, S. Alice Long, Peter S. Linsley, Todd M. Brusko
Publikováno v:
JCI Insight, Vol 8, Iss 16 (2023)
BACKGROUND Low-dose anti–thymocyte globulin (ATG) transiently preserves C-peptide and lowers HbA1c in individuals with recent-onset type 1 diabetes (T1D); however, the mechanisms of action and features of the response remain unclear. Here, we chara
Externí odkaz:
https://doaj.org/article/ad46bb6a2d254bafb3f6b3213915a443
Autor:
Warren Anderson, Fariba Barahmand-pour-Whitman, Peter S Linsley, Karen Cerosaletti, Jane H Buckner, David J Rawlings
Publikováno v:
eLife, Vol 12 (2023)
A genetic variant in the gene PTPN22 (R620W, rs2476601) is strongly associated with increased risk for multiple autoimmune diseases and linked to altered TCR regulation and T cell activation. Here, we utilize Crispr/Cas9 gene editing with donor DNA r
Externí odkaz:
https://doaj.org/article/3e6736e42d8c4ec0adf0ff3beeb58b90
Autor:
George N. Ioannou, Sum P. Lee, Peter S. Linsley, Vivian Gersuk, Matthew M. Yeh, Yen‐Ying Chen, Yi‐Jen Peng, Moumita Dutta, Gabby Mascarinas, Bruk Molla, Julia Yue Cui, Christopher Savard
Publikováno v:
Hepatology Communications, Vol 6, Iss 4, Pp 780-794 (2022)
Proprotein convertase subtilisin/kexin type 9 (Pcsk9) binds to hepatic low‐density lipoprotein receptor (LDLR) and induces its internalization and degradation. Pcsk9 inhibition increases LDLR expression by hepatocytes, which causes increased uptake
Externí odkaz:
https://doaj.org/article/ef686476bec244748709ac6cd63fc5bf
Autor:
Katharina Lambert, Kirsten E. Diggins, Britta E. Jones, Christian Hundhausen, Megan D. Maerz, Anne M. Hocking, Srinath Sanda, Carla J. Greenbaum, Peter S. Linsley, Karen Cerosaletti, Jane H. Buckner
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Elevated levels and enhanced sensing of the pro-inflammatory cytokine interleukin-6 (IL-6) are key features of many autoimmune and inflammatory diseases. To better understand how IL-6 signaling may influence human T cell fate, we investigated the rel
Externí odkaz:
https://doaj.org/article/c773700586e44a7c8cb9899ec2c188f9
Autor:
Alyssa Sheih, Valentin Voillet, Laïla-Aïcha Hanafi, Hannah A. DeBerg, Masanao Yajima, Reed Hawkins, Vivian Gersuk, Stanley R. Riddell, David G. Maloney, Martin E. Wohlfahrt, Dnyanada Pande, Mark R. Enstrom, Hans-Peter Kiem, Jennifer E. Adair, Raphaël Gottardo, Peter S. Linsley, Cameron J. Turtle
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Understanding factors that impact CAR T cell expansion in the clinic is crucial to improving its therapeutic success. Here the authors document heterogeneity in the clonal dynamics of CAR-T cells by tracking individual clones using the endogenous TCR
Externí odkaz:
https://doaj.org/article/9a5dfb14385d4c6ba59269c0303b6190
Autor:
Peter S. Linsley, Fariba Barahmand-pour-Whitman, Elisa Balmas, Hannah A. DeBerg, Kaitlin J. Flynn, Alex K. Hu, Mario G. Rosasco, Janice Chen, Colin O’Rourke, Elisavet Serti, Vivian H. Gersuk, Keshav Motwani, Howard R. Seay, Todd M. Brusko, William W. Kwok, Cate Speake, Carla J. Greenbaum, Gerald T. Nepom, Karen Cerosaletti
Publikováno v:
JCI Insight, Vol 6, Iss 22 (2021)
Human islet antigen reactive CD4+ memory T cells (IAR T cells) play a key role in the pathogenesis of autoimmune type 1 diabetes (T1D). Using single-cell RNA sequencing (scRNA-Seq) to identify T cell receptors (TCRs) in IAR T cells, we have identifie
Externí odkaz:
https://doaj.org/article/ae78e844c0644847af1e433a33d6fd7d