Zobrazeno 1 - 10
of 29
pro vyhledávání: '"P S, Gaynon"'
Autor:
Sarah K. Tasian, Lewis B. Silverman, James A. Whitlock, Richard Sposto, Joseph P. Loftus, Eric S. Schafer, Kirk R. Schultz, Raymond J. Hutchinson, Paul S. Gaynon, Etan Orgel, Caroline M. Bateman, Todd M. Cooper, Theodore W. Laetsch, Maria Luisa Sulis, Yueh-Yun Chi, Jemily Malvar, Alan S. Wayne, Susan R. Rheingold
Publikováno v:
Haematologica, Vol 107, Iss 10 (2022)
Phosphatidylinositol 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) signaling is commonly dysregulated in acute lymphoblastic leukemia (ALL). The TACL2014-001 phase I trial of the mTOR inhibitor temsirolimus in combination with cyclophosphamide
Externí odkaz:
https://doaj.org/article/8445bc9f98404419b1d22c8a88c190ec
Autor:
Paul S. Gaynon
Publikováno v:
Haematologica, Vol 103, Iss 1 (2018)
Externí odkaz:
https://doaj.org/article/95310328a46349ebafc6752cfcc59d3e
Autor:
Paul S. Gaynon
Publikováno v:
Haematologica, Vol 102, Iss 3 (2017)
Externí odkaz:
https://doaj.org/article/0645845caa03404894a386de44f07ed2
Autor:
Yin eLiu, Jingyan eTang, Peter eWakamatsu, Huiliang eXue, Jing eChen, Paul S Gaynon, Shuhong eShen, Weili eSun
Publikováno v:
Frontiers in Pediatrics, Vol 2 (2014)
Background: Molecular genetic alterations with prognostic significance have been described in childhood acute myeloid leukemia (AML). The aim of this study was to establish cost-effective techniques to detect mutations of FMS-like tyrosine kinase 3 (
Externí odkaz:
https://doaj.org/article/97e3a66bbc654a33a0d72b3de3d4a039
Autor:
Fatih M Uckun, Hong Ma, Rita Ishkhanian, Martha Arellano, Anoush Shahidzadeh, Amanda Termuhlen, Paul S Gaynon, Sanjive Qazi
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e80732 (2013)
We examined the constitutive function of the Ikaros (IK) transcription factor in blast cells from pediatric B-precursor acute lymphoblastic leukemia (BPL) patients using multiple assay platforms and bioinformatics tools. We found no evidence of dimin
Externí odkaz:
https://doaj.org/article/637b1c2c2da34a5e8c5ea8b392ceca3b
Autor:
N A, Heerema, H N, Sather, M G, Sensel, M K, Lee, R, Hutchinson, J B, Nachman, B J, Lange, P G, Steinherz, B, Bostrom, P S, Gaynon, F M, Uckun
Publikováno v:
Cancer. 88(8)
The authors have determined the prognostic significance of cytogenetically detectable 12p abnormalities, which are frequent in children with acute lymphoblastic leukemia (ALL), in a large cohort of patients treated on risk-adjusted protocols of the C
Autor:
P S, Gaynon, A L, Carrel
Publikováno v:
Advances in experimental medicine and biology. 457
Treatment of childhood acute lymphoblastic leukemia has included glucocorticosteroids for almost 50 years. Glucocorticoids are the subject of renewed interest. In one randomized trial, deferral of glucocorticosteroids from the initial month of induct
Publikováno v:
Journal of pediatric hematology/oncology. 21(1)
Although splenectomy is the most effective treatment for chronic idiopathic thrombocytopenic purpura (ITP), many post-splenectomy patients have recurrent thrombocytopenia refractory to multiple medical therapies. Three consecutive patients with relap
Autor:
F M, Uckun, J B, Nachman, H N, Sather, M G, Sensel, P, Kraft, P G, Steinherz, B, Lange, R, Hutchinson, G H, Reaman, P S, Gaynon, N A, Heerema
Publikováno v:
Cancer. 83(9)
Children with Philadelphia (Ph) chromosome positive (+) acute lymphoblastic leukemia (ALL) represent a subgroup at very high risk for treatment failure. In this report, the authors assessed the outcome of Ph+ ALL in a large cohort of children treated
Autor:
P S, Gaynon, R P, Qu, R J, Chappell, M L, Willoughby, D G, Tubergen, P G, Steinherz, M E, Trigg
Publikováno v:
Cancer. 82(7)
Childhood acute lymphoblastic leukemia is the single most common childhood malignancy. Despite substantial improvements in therapy, cases in which relapse occurs are still more common than newly diagnosed cases of many other childhood cancers. The su