Výsledky vyhledávání - "P S, Brzovic"

Akademický článek

Legionella effector MavC targets the Ube2N~Ub conjugate for noncanonical ubiquitination

Autor: Kedar Puvar, Shalini Iyer, Jiaqi Fu, Sebastian Kenny, Kristos I. Negrón Terón, Zhao-Qing Luo, Peter S. Brzovic, Rachel E. Klevit, Chittaranjan Das

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)

The Legionella pneumophila effector MavC inhibits the human ubiquitin-conjugating enzyme Ube2N. Here, the authors combine NMR, X-ray crystallography and biochemical assays and show that MavC catalyses the intramolecular transglutaminase reaction betw

Externí odkaz: https://doaj.org/article/648e9d96e29748c9b52e0dbcb435943c

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Akademický článek

Salmonella Translocated Effectors Recruit OSBP1 to the Phagosome to Promote Vacuolar Membrane Integrity

Autor: Anna M. Kolodziejek, Melissa A. Altura, Junping Fan, Erik M. Petersen, Matthew Cook, Peter S. Brzovic, Samuel I. Miller

Publikováno v: Cell Reports, Vol 27, Iss 7, Pp 2147-2156.e5 (2019)

Summary: Intracellular Salmonella use a type III secretion system (TTSS) to translocate effector proteins across the phagosome membrane and thus promote vacuole membrane tubulation, resulting in intracellular survival. This work demonstrates that the

Externí odkaz: https://doaj.org/article/b601ce380b8f420ea55a922f7f2a0a92

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Structure of a BRCA1-BARD1 heterodimeric RING-RING complex

Autor: P S, Brzovic, P, Rajagopal, D W, Hoyt, M C, King, R E, Klevit

Publikováno v: Nature structural biology. 8(10)

The RING domain of the breast and ovarian cancer tumor suppressor BRCA1 interacts with multiple cognate proteins, including the RING protein BARD1. Proper function of the BRCA1 RING domain is critical, as evidenced by the many cancer-predisposing mut

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0b5e8540f79f657dfc79af05b3916faf
https://pubmed.ncbi.nlm.nih.gov/11573079

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BRCA1 RING domain cancer-predisposing mutations. Structural consequences and effects on protein-protein interactions

Autor: P S, Brzovic, J E, Meza, M C, King, R E, Klevit

Publikováno v: The Journal of biological chemistry. 276(44)

Cancer-predisposing missense mutations in the RING domain of BRCA1 primarily target Zn(2+)-liganding residues. Here we report on the structural consequences of such mutations introduced into the second Zn(2+) site (Site II) of the BRCA1 RING domain a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::694c2d8f893d1a5963f00bc29b42e235
https://pubmed.ncbi.nlm.nih.gov/11526114

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Mapping the functional domains of BRCA1. Interaction of the ring finger domains of BRCA1 and BARD1

Autor: J E, Meza, P S, Brzovic, M C, King, R E, Klevit

Publikováno v: The Journal of biological chemistry. 274(9)

Breast cancer 1 (BRCA1) and BRCA1-associated RING domain 1 (BARD1) are multidomain proteins that interact in vivo via their N-terminal RING finger motif regions. To characterize functional aspects of the BRCA1/BARD1 interaction, we have defined the s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7fe006f0b81c2421a8a58a44330f99ef
https://pubmed.ncbi.nlm.nih.gov/10026184

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Spectroscopic evidence for preexisting T- and R-state insulin hexamer conformations

Autor: W E, Choi, D, Borchardt, N C, Kaarsholm, P S, Brzovic, M F, Dunn

Publikováno v: Proteins. 26(4)

The insulin hexamer is an allosteric protein exhibiting both positive and negative cooperative homotropic interactions and positive cooperative heterotropic interactions (C. R. Bloom et al., J. Mol. Biol. 245, 324-330, 1995). In this study, detailed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d9b4bec746c73b1a269926636cf4ecbf
https://pubmed.ncbi.nlm.nih.gov/8990494

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