Zobrazeno 1 - 10
of 675
pro vyhledávání: '"P S, Aisen"'
Autor:
Sheila Seleri Assunção, Reisa A. Sperling, Craig Ritchie, Diana R. Kerwin, Paul S. Aisen, Claire Lansdall, Alireza Atri, Jeffrey Cummings
Publikováno v:
Alzheimer’s Research & Therapy, Vol 14, Iss 1, Pp 1-16 (2022)
Abstract Background The need for preventive therapies that interrupt the progression of Alzheimer’s disease (AD) before the onset of symptoms or when symptoms are emerging is urgent and has spurred the ongoing development of disease-modifying thera
Externí odkaz:
https://doaj.org/article/9aafec3bb32b46c8a303bf7ad81ced17
Autor:
Michael F. Egan, Yuki Mukai, Tiffini Voss, James Kost, Julie Stone, Christine Furtek, Erin Mahoney, Jeffrey L. Cummings, Pierre N. Tariot, Paul S. Aisen, Bruno Vellas, Christopher Lines, David Michelson
Publikováno v:
Alzheimer’s Research & Therapy, Vol 11, Iss 1, Pp 1-12 (2019)
Abstract Background Verubecestat, a BACE1 inhibitor that reduces Aβ levels in the cerebrospinal fluid of humans, was not effective in a phase 3 trial (EPOCH) of mild-to-moderate AD and was associated with adverse events. To assist in the development
Externí odkaz:
https://doaj.org/article/b7a42dd59c2848208857c8ea93bf3567
Autor:
Samuel Iddi, Dan Li, Paul S. Aisen, Michael S. Rafii, Wesley K. Thompson, Michael C. Donohue, for the Alzheimer’s Disease Neuroimaging Initiative
Publikováno v:
Brain Informatics, Vol 6, Iss 1, Pp 1-18 (2019)
Abstract Alzheimer’s disease is the most common neurodegenerative disease and is characterized by the accumulation of amyloid-beta peptides leading to the formation of plaques and tau protein tangles in brain. These neuropathological features prece
Externí odkaz:
https://doaj.org/article/872ef89c3b39477db905b540155a5403
Autor:
Kenichiro Sato, Ryoko Ihara, Kazushi Suzuki, Yoshiki Niimi, Tatsushi Toda, Gustavo Jimenez‐Maggiora, Oliver Langford, Michael C. Donohue, Rema Raman, Paul S. Aisen, Reisa A. Sperling, Atsushi Iwata, Takeshi Iwatsubo
Publikováno v:
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol 7, Iss 1, Pp n/a-n/a (2021)
Abstract Background Selecting cognitively normal elderly individuals with higher risk of brain amyloid deposition is critical to the success of prevention trials for Alzheimer's disease (AD). Methods Based on the Anti‐Amyloid Treatment in Asymptoma
Externí odkaz:
https://doaj.org/article/460550e1d9d545d39d1fb9b1029d4fe6
Autor:
Jennifer Ngolab, Michael Donohue, Alison Belsha, Jennifer Salazar, Paula Cohen, Sandhya Jaiswal, Veasna Tan, Devon Gessert, Shaina Korouri, Neelum T. Aggarwal, Jessica Alber, Ken Johnson, Gregory Jicha, Christopher vanDyck, James Lah, Stephen Salloway, Reisa A. Sperling, Paul S. Aisen, Michael S. Rafii, Robert A. Rissman
Publikováno v:
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 13, Iss 1, Pp n/a-n/a (2021)
Abstract Introduction The retina and brain exhibit similar pathologies in patients diagnosed with neurodegenerative diseases. The ability to access the retina through imaging techniques opens the possibility for non‐invasive evaluation of Alzheimer
Externí odkaz:
https://doaj.org/article/84744694b7414dd081f355d9ea48259f
Autor:
Gad A. Marshall, Sietske A. M. Sikkes, Rebecca E. Amariglio, Jennifer R. Gatchel, Dorene M. Rentz, Keith A. Johnson, Oliver Langford, Chung‐Kai Sun, Michael C. Donohue, Rema Raman, Paul S. Aisen, Reisa A. Sperling, Douglas R. Galasko, Full listing of A4 Study team and site personnel available at A4STUDY.org
Publikováno v:
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 12, Iss 1, Pp n/a-n/a (2020)
Abstract Introduction We examined the associations among instrumental activities of daily living (IADL), cortical amyloid, and cognition in cognitively normal (CN) older adults. Methods CN participants screening for the A4 Study (n = 4486) underwent
Externí odkaz:
https://doaj.org/article/857ced60289a418e812be6ece7d75879
Autor:
Dan Li, Samuel Iddi, Wesley K. Thompson, Michael S. Rafii, Paul S. Aisen, Michael C. Donohue, Alzheimer's Disease Neuroimaging Initiative
Publikováno v:
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 10, Iss 1, Pp 657-668 (2018)
Abstract Introduction We characterize long‐term disease dynamics from cognitively healthy to dementia using data from the Alzheimer's Disease Neuroimaging Initiative. Methods We apply a latent time joint mixed‐effects model to 16 cognitive, funct
Externí odkaz:
https://doaj.org/article/0aa98729b2144b99a9649a7635eb8077
Autor:
Paul S. Aisen, Jeffrey Cummings, Clifford R. Jack, John C. Morris, Reisa Sperling, Lutz Frölich, Roy W. Jones, Sherie A. Dowsett, Brandy R. Matthews, Joel Raskin, Philip Scheltens, Bruno Dubois
Publikováno v:
Alzheimer’s Research & Therapy, Vol 9, Iss 1, Pp 1-10 (2017)
Abstract Basic research advances in recent years have furthered our understanding of the natural history of Alzheimer’s disease (AD). It is now recognized that pathophysiological changes begin many years prior to clinical manifestations of disease
Externí odkaz:
https://doaj.org/article/cc9d4a43fe0c412baa97aca4e96639b8
Autor:
Kwangsik Nho, Sungeun Kim, Emrin Horgusluoglu, Shannon L. Risacher, Li Shen, Dokyoon Kim, Seunggeun Lee, Tatiana Foroud, Leslie M. Shaw, John Q. Trojanowski, Paul S. Aisen, Ronald C. Petersen, Clifford R. Jack, Michael W. Weiner, Robert C. Green, Arthur W. Toga, Andrew J. Saykin, for the Alzheimer’s Disease Neuroimaging Initiative (ADNI)
Publikováno v:
BMC Medical Genomics, Vol 10, Iss S1, Pp 45-52 (2017)
Abstract Background The APOE ε4 allele is the most significant common genetic risk factor for late-onset Alzheimer’s disease (LOAD). The region surrounding APOE on chromosome 19 has also shown consistent association with LOAD. However, no common v
Externí odkaz:
https://doaj.org/article/76a4ec0965754d1681c63c08b1ea7026
Autor:
Sona Hurtz, Nicole Chow, Amity E. Watson, Johanne H. Somme, Naira Goukasian, Kristy S. Hwang, John Morra, David Elashoff, Sujuan Gao, Ronald C. Petersen, Paul S. Aisen, Paul M. Thompson, Liana G. Apostolova
Publikováno v:
NeuroImage: Clinical, Vol 21, Iss , Pp - (2019)
Background: Imaging techniques used to measure hippocampal atrophy are key to understanding the clinical progression of Alzheimer's disease (AD). Various semi-automated hippocampal segmentation techniques are available and require human expert input
Externí odkaz:
https://doaj.org/article/068a17dcaea0428ba92814974e9bbbe7