Zobrazeno 1 - 10
of 143
pro vyhledávání: '"P Rod Dunbar"'
Autor:
Nicholas Waldron, P Rod Dunbar, Sanjeev Deva, Oh Kyu Yoon, John Ling, Kai-Wen Lin, Dung Thai, Latesh Lad, Ahmed A Othman, Jared M Odegard, Adele Y Wang, Jonathan Nazareno, Edmond Ang
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 4 (2024)
Background Checkpoint inhibitors targeting the programmed cell death 1 (PD-1)/programmed cell death 1 ligand 1 (PD-L1) pathway are effective therapies in a range of immunogenic cancer types. Blocking this pathway with an oral therapy could benefit pa
Externí odkaz:
https://doaj.org/article/2b728df121a442dc8e3c4516f01ebf5f
Autor:
Kef K Prasit, Laura Ferrer-Font, Olivia K Burn, Regan J Anderson, Benjamin J Compton, Alfonso J Schmidt, Johannes U Mayer, Chun-Jen J Chen, Nathaniel Dasyam, David S Ritchie, Dale I Godfrey, Stephen R Mattarollo, P Rod Dunbar, Gavin F Painter, Ian F Hermans
Publikováno v:
OncoImmunology, Vol 11, Iss 1 (2022)
Intratumoural administration of unmethylated cytosine-phosphate-guanine motifs (CpG) to stimulate toll-like receptor (TLR)-9 has been shown to induce tumour regression in preclinical studies and some efficacy in the clinic. Because activated natural
Externí odkaz:
https://doaj.org/article/423fa268183140eca4c64e8a2ff85aed
Autor:
John F Thompson, Peter Hersey, Michael Millward, Paul Nathan, Weisan Chen, Ralph Venhaus, Andreas Behren, Cyril Fisher, Jonathan S Cebon, Martin Gore, Ian D Davis, Grant A McArthur, Euan Walpole, Mark Smithers, Vincenzo Cerundolo, P Rod Dunbar, Duncan MacGregor, Michael P N Findlay, T R Jeffry Evans, Jeremy Marsden, Angus G Dalgleish, Pippa G Corrie, Marples Maria, Margaret Brimble, Geoff Williams, Sintia Winkler, Heather M Jackson, Liliana Endo-Munoz, Candani S A Tutuka, Lloyd J Old, Dennis Haack, Eugene Maraskovsky
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 1 (2020)
Background To compare the clinical efficacy of New York Esophageal squamous cell carcinoma-1 (NY-ESO-1) vaccine with ISCOMATRIX adjuvant versus ISCOMATRIX alone in a randomized, double-blind phase II study in participants with fully resected melanoma
Externí odkaz:
https://doaj.org/article/180a81075c10497e8c8ac926325f3b4e
Publikováno v:
PLoS Biology, Vol 17, Iss 12, p e3000486 (2019)
The conduit network is a hallmark of lymph node microanatomy, but lack of suitable imaging technology has prevented comprehensive investigation of its topology. We employed an extended-volume imaging system to capture the conduit network of an entire
Externí odkaz:
https://doaj.org/article/96844b319a7a4b62a1d5241bf26efa2c
Autor:
Jeremy M Raynes, Hannah RC Frost, Deborah A Williamson, Paul G Young, Edward N Baker, John D Steemson, Jacelyn M Loh, Thomas Proft, P Rod Dunbar, Polly E Atatoa Carr, Anita Bell, Nicole Jane Moreland
Publikováno v:
Frontiers in Microbiology, Vol 7 (2016)
Acute rheumatic fever (ARF) is an autoimmune response to Group A Streptococcus (GAS) infection. Repeated GAS exposures are proposed to ‘prime’ the immune system for autoimmunity. This notion of immune-priming by multiple GAS infections was first
Externí odkaz:
https://doaj.org/article/0239d17305a44fdab193de3641e8bb5f
Autor:
Julie D McIntosh, Kristy Manning, Shilpa Chokshi, Nikolai V Naoumov, John D Fraser, P Rod Dunbar, John A Taylor
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e93598 (2014)
Virus like particles (VLPs) are potent immunogens capable of priming strong protective antibody responses due to their repetitive structural arrangement and affinity for specific B cell receptors. By contrast, T cell responses to VLPs can be weak due
Externí odkaz:
https://doaj.org/article/8d816d7e762a4370925e7ff5ba33e665
Autor:
Saem Mul Park, Catherine E Angel, Julie D McIntosh, Claudia J Mansell, Chun-Jen J Chen, Jonathon Cebon, P Rod Dunbar
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e94781 (2014)
The lymphatic sinuses in human lymph nodes (LNs) are crucial to LN function yet their structure remains poorly defined. Much of our current knowledge of lymphatic sinuses derives from rodent models, however human LNs differ substantially in their sin
Externí odkaz:
https://doaj.org/article/08c4283c5caf42949d57a6c175e07245
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e62753 (2013)
The study of melanocyte biology is important to understand their role in health and disease. However, current methods of gene transfer into melanocytes are limited by safety or efficacy. Recombinant adeno-associated virus (rAAV) has been extensively
Externí odkaz:
https://doaj.org/article/e972f4073f5643dea0cd96d0ba80ba96
Autor:
Gib Bogle, P Rod Dunbar
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e45258 (2012)
Agent-based simulation is a powerful method for investigating the complex interplay of the processes occurring in a lymph node during an adaptive immune response. We have previously established an agent-based modeling framework for the interactions b
Externí odkaz:
https://doaj.org/article/e8eb9a4bf51c4b6bbfd594d9a1d367ec
Autor:
Laura Papagno, Celsa A Spina, Arnaud Marchant, Mariolina Salio, Nathalie Rufer, Susan Little, Tao Dong, Gillian Chesney, Anele Waters, Philippa Easterbrook, P Rod Dunbar, Dawn Shepherd, Vincenzo Cerundolo, Vincent Emery, Paul Griffiths, Christopher Conlon, Andrew J McMichael, Douglas D Richman, Sarah L Rowland-Jones, Victor Appay
Publikováno v:
PLoS Biology, Vol 2, Iss 2, p E20 (2004)
Progress in the fight against the HIV/AIDS epidemic is hindered by our failure to elucidate the precise reasons for the onset of immunodeficiency in HIV-1 infection. Increasing evidence suggests that elevated immune activation is associated with poor
Externí odkaz:
https://doaj.org/article/9c5d9bfcd3b640d6b9963bb03ac78d0a