Zobrazeno 1 - 10
of 59
pro vyhledávání: '"P Robinan, Gentry"'
Autor:
Ali A. Rostami, Jerry L. Campbell, Yezdi B. Pithawalla, Hamideh Pourhashem, Raheema S. Muhammad-Kah, Mohamadi A. Sarkar, Jianmin Liu, Willie J. McKinney, Robinan Gentry, Maria Gogova
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-18 (2022)
Abstract Physiologically based pharmacokinetic (PBPK) modeling can be a useful tool for characterizing nicotine pharmacokinetics (PK) from use of tobacco products. We expand a previously published PBPK model to simulate a nicotine PK profile, followi
Externí odkaz:
https://doaj.org/article/30402a91565447e0a0d12ad30d1ac0c2
Autor:
Rory P. Conolly, Harvey J. Clewell, Martha M. Moore, Jerry L. Campbell, Wanyun Cheng, R. Robinan Gentry
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Introduction: A physiologically based pharmacokinetic (PBPK) model for 3-chloroallyl alcohol (3-CAA) was developed and used to evaluate the design of assays for the in vivo genotoxicity of 3-CAA.Methods: Model development was supported by read across
Externí odkaz:
https://doaj.org/article/d8f7461641fa4ee682ebb9ff72cdf343
Autor:
Rory B Conolly, Jeffry Schroeter, Julia S Kimbell, Harvey Clewell, Melvin E Andersen, P Robinan Gentry
Publikováno v:
Toxicological Sciences. 193:1-17
Chronic inhalation of formaldehyde by F344 rats causes nasal squamous cell carcinoma (SCC). This outcome is well-characterized: including dose-response and time course data for SCC, mechanistic endpoints, and nasal dosimetry. Conolly et al. (Toxicol.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::75ff9a35902172063ef6228b4684274b
https://doi.org/10.1093/toxsci/kfad028
https://doi.org/10.1093/toxsci/kfad028
Autor:
Ali A. Rostami, Jerry L. Campbell, Yezdi B. Pithawalla, Hamideh Pourhashem, Raheema S. Muhammad-Kah, Mohamadi A. Sarkar, Jianmin Liu, Willie J. McKinney, Robinan Gentry, Maria Gogova
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/45206e653006461698478f0987a342c5
Autor:
Rory B, Conolly, Jerry L, Campbell, Harvey J, Clewell, Jeffry, Schroeter, Julia S, Kimbell, P Robinan, Gentry
Publikováno v:
Toxicological Sciences. 191:15-24
Understanding the dose-response for formaldehyde-induced nasal cancer in rats is complicated by (1) the uneven distribution of inhaled formaldehyde across the interior surface of the nasal cavity and, (2) the presence of endogenous formaldehyde (endo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bde6602d72d410cbfe9162760058e888
https://doi.org/10.1093/toxsci/kfac119
https://doi.org/10.1093/toxsci/kfac119
Autor:
Jerry L Campbell, Harvey J Clewell, Cynthia Van Landingham, P Robinan Gentry, Athena M Keene, Michael D Taylor, Melvin E Andersen
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology.
In earlier physiologically based pharmacokinetic (PBPK) models for manganese (Mn), the kinetics of transport of Mn into and out of tissues were primarily driven by slow rates of association and dissociation of Mn with tissue binding sites. However, M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83ef7816aef3f1c7f85d4097bbbdfcd0
https://pubmed.ncbi.nlm.nih.gov/36453847
https://pubmed.ncbi.nlm.nih.gov/36453847
Publikováno v:
Risk Analysis
β‐Chloroprene is used in the production of polychloroprene, a synthetic rubber. In 2010, Environmental Protection Agency (EPA) published the Integrated Risk Information System “Toxicological Review of Chloroprene,” concluding that chloroprene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10cdf1a4f1a82af32b1cac88fb2656ef
https://doi.org/10.1111/risa.13397
https://doi.org/10.1111/risa.13397
Autor:
James S. Bus, David Coggon, James A. Swenberg, Gary M. Marsh, P. Robinan Gentry, Helmut Greim, James H. Sherman, Hermann M. Bolt, Melvin E. Andersen, Kenneth A. Mundt, Kimberly W. White, Harvey J. Clewell, Chad M. Thompson, Harvey Checkoway
Publikováno v:
Regulatory toxicology and pharmacology, 106:210-223
Anticipating the need to evaluate and integrate scientific evidence to inform new risk assessments or to update existing risk assessments, the Formaldehyde Panel of the American Chemistry Council (ACC), in collaboration with the University of North C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98c81b208178372aeed7dc9cbcbe222b
https://doi.org/10.1016/j.yrtph.2019.04.015
https://doi.org/10.1016/j.yrtph.2019.04.015
Publikováno v:
Risk Analysis
We review approaches for characterizing “peak” exposures in epidemiologic studies and methods for incorporating peak exposure metrics in dose–response assessments that contribute to risk assessment. The focus was on potential etiologic relation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2456df7a5b3e10dbfa7697dc6956a2a9
http://europepmc.org/articles/PMC6850123
http://europepmc.org/articles/PMC6850123
Autor:
P. Robinan Gentry, Melvin E. Andersen, Janice W. Yager, Rebecca A. Clewell, Pergentino Balbuena, Harvey J. Clewell, Michael B. Black, Linda J. Pluta, Alina Efremenko
Publikováno v:
Toxicology. 461
Evidence from both in vivo and in vitro studies suggests that gene expression changes from long-term exposure to arsenite evolve markedly over time, including reversals in the direction of expression change in key regulatory genes. In this study, hum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30c95e51d82e71bc0521487de0889add
https://pubmed.ncbi.nlm.nih.gov/34425169
https://pubmed.ncbi.nlm.nih.gov/34425169